ID Q6P3J8_DANRE Unreviewed; 375 AA.
AC Q6P3J8; A0A8M1PPF7;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 135.
DE SubName: Full=L-threonine 3-dehydrogenase, mitochondrial {ECO:0000313|RefSeq:NP_998410.1, ECO:0000313|RefSeq:XP_005160513.1};
DE EC=1.1.1.103 {ECO:0000313|RefSeq:NP_998410.1};
DE SubName: Full=L-threonine dehydrogenase {ECO:0000313|EMBL:AAH63962.1, ECO:0000313|Ensembl:ENSDARP00000024225};
GN Name=tdh {ECO:0000313|EMBL:AAH63962.1,
GN ECO:0000313|Ensembl:ENSDARP00000024225,
GN ECO:0000313|RefSeq:NP_998410.1, ECO:0000313|RefSeq:XP_005160513.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040426-2379};
GN Synonyms=wu:fc11b08 {ECO:0000313|RefSeq:NP_998410.1,
GN ECO:0000313|RefSeq:XP_005160513.1}, zgc:77667
GN {ECO:0000313|RefSeq:NP_998410.1, ECO:0000313|RefSeq:XP_005160513.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH63962.1};
RN [1] {ECO:0000313|RefSeq:NP_998410.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9409775;
RA Gong Z., Yan T., Liao J., Lee S.E., He J., Hew C.L.;
RT "Rapid identification and isolation of zebrafish cDNA clones.";
RL Gene 201:87-98(1997).
RN [2] {ECO:0000313|EMBL:AAH63962.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Whole {ECO:0000313|EMBL:AAH63962.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000024225}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000024225};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSDARP00000024225, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000024225};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_998410.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [6] {ECO:0000313|RefSeq:NP_998410.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [7] {ECO:0000313|RefSeq:NP_998410.1, ECO:0000313|RefSeq:XP_005160513.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005160513.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BX510941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC063962; AAH63962.1; -; mRNA.
DR RefSeq; NP_998410.1; NM_213245.1.
DR RefSeq; XP_005160513.1; XM_005160456.2.
DR STRING; 7955.ENSDARP00000024225; -.
DR PaxDb; 7955-ENSDARP00000114681; -.
DR Ensembl; ENSDART00000025509.7; ENSDARP00000024225.5; ENSDARG00000002745.10.
DR Ensembl; ENSDART00000147105.3; ENSDARP00000114681.1; ENSDARG00000002745.10.
DR GeneID; 406528; -.
DR KEGG; dre:406528; -.
DR AGR; ZFIN:ZDB-GENE-040426-2379; -.
DR CTD; 157739; -.
DR ZFIN; ZDB-GENE-040426-2379; tdh.
DR eggNOG; KOG2774; Eukaryota.
DR OMA; HWHASPR; -.
DR OrthoDB; 177053at2759; -.
DR TreeFam; TF314544; -.
DR Proteomes; UP000000437; Chromosome 20.
DR Bgee; ENSDARG00000002745; Expressed in pharyngeal gill and 45 other cell types or tissues.
DR GO; GO:0008743; F:L-threonine 3-dehydrogenase activity; IBA:GO_Central.
DR GO; GO:0006567; P:threonine catabolic process; IBA:GO_Central.
DR CDD; cd05272; TDH_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR42687; L-THREONINE 3-DEHYDROGENASE; 1.
DR PANTHER; PTHR42687:SF4; L-THREONINE 3-DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q6P3J8};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 60..295
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 375 AA; 41648 MW; A0B8EC1879F9E83D CRC64;
MPVIRALSKV AKQALLAPAC GCQPLTVAIR NISFSPRQVT SASDASFHSV SFSETDHPKV
LITGGLGQLG VGLAKLLRKR FGKNNVILSD IRKPPSNVFH SGPFIYSDIL DYKNLREIVV
NNRITWLVHY SALLSAVGEA NVALARAVNI TGLHNILDIA AEHGLRLFVP STIGAFGPTS
PRNPTPDLCV QRPRTIYGVS KVHAELMGEY YHHRYGLDFR CLRYPGIISA DSQPGGGTTD
YAVQIFHDAV KTGKFECNLK PDTRLPMMYI DDCLRATLEV MEAPLETLSM RTYNINAMSF
TPEELANEVQ KQLPDLQVSY EIDSVRQAIA DSWPMNFDDT NARNDWGWKH DYDLPELVQT
MLNYIGSESR IAQAN
//
