ID Q6PBP1_DANRE Unreviewed; 354 AA.
AC Q6PBP1; A0A8M1PFR7;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 141.
DE SubName: Full=Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O {ECO:0000313|EMBL:AAH59637.1};
DE SubName: Full=Guanine nucleotide-binding protein (G protein), alpha-activating activity polypeptide O, a {ECO:0000313|Ensembl:ENSDARP00000124476};
DE SubName: Full=Guanine nucleotide-binding protein G(O) subunit alpha {ECO:0000313|RefSeq:NP_957081.1};
GN Name=gnao1 {ECO:0000313|EMBL:AAH59637.1,
GN ECO:0000313|RefSeq:NP_957081.1};
GN Synonyms=wu:fq26h05 {ECO:0000313|RefSeq:NP_957081.1}, zgc:73315
GN {ECO:0000313|RefSeq:NP_957081.1};
GN OrderedLocusNames=gnao1a {ECO:0000313|Ensembl:ENSDARP00000124476,
GN ECO:0000313|RefSeq:NP_957081.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040426-1757};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH59637.1};
RN [1] {ECO:0000313|EMBL:AAH59637.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Wild-type {ECO:0000313|EMBL:AAH59637.1};
RC TISSUE=Eye {ECO:0000313|EMBL:AAH59637.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_957081.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_957081.1};
RX PubMed=19164534; DOI=10.1073/pnas.0809420106;
RA Oka Y., Saraiva L.R., Kwan Y.Y., Korsching S.I.;
RT "The fifth class of Galpha proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:1484-1489(2009).
RN [3] {ECO:0000313|RefSeq:NP_957081.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_957081.1};
RX PubMed=21242316;
RA Oka Y., Korsching S.I.;
RT "Shared and unique G alpha proteins in the zebrafish versus mammalian
RT senses of taste and smell.";
RL Chem. Senses 36:357-365(2011).
RN [4] {ECO:0000313|RefSeq:NP_957081.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_957081.1};
RX PubMed=22523578; DOI=10.1371/journal.pone.0035256;
RA Huang Y.Y., Haug M.F., Gesemann M., Neuhauss S.C.;
RT "Novel expression patterns of metabotropic glutamate receptor 6 in the
RT zebrafish nervous system.";
RL PLoS ONE 7:e35256-e35256(2012).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000124476}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000124476};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [6] {ECO:0000313|Ensembl:ENSDARP00000124476, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000124476};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [7] {ECO:0000313|RefSeq:NP_957081.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_957081.1};
RX PubMed=26555542;
RA Suzuki H., Nikaido M., Hagino-Yamagishi K., Okada N.;
RT "Distinct functions of two olfactory marker protein genes derived from
RT teleost-specific whole genome duplication.";
RL BMC Evol. Biol. 15:245-245(2015).
RN [8] {ECO:0000313|RefSeq:NP_957081.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_957081.1};
RX PubMed=26571427;
RA Teoh S.L., Ogawa S., Parhar I.S.;
RT "Localization of genes encoding metallothionein-like protein (mt2 and smtb)
RT in the brain of zebrafish.";
RL J. Chem. Neuroanat. 70:20-32(2015).
RN [9] {ECO:0000313|RefSeq:NP_957081.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_957081.1};
RX PubMed=26469318;
RA Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA Reith W., Hertzano R.;
RT "RFX transcription factors are essential for hearing in mice.";
RL Nat. Commun. 6:8549-8549(2015).
RN [10] {ECO:0000313|RefSeq:NP_957081.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_957081.1};
RX PubMed=28026967;
RA Chen L., Au D.W., Hu C., Peterson D.R., Zhou B., Qian P.Y.;
RT "Identification of Molecular Targets for 4,5-Dichloro-2-n-octyl-4-
RT isothiazolin-3-one (DCOIT) in Teleosts: New Insight into Mechanism of
RT Toxicity.";
RL Environ. Sci. Technol. 51:1840-1847(2017).
RN [11] {ECO:0000313|RefSeq:NP_957081.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_957081.1};
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [12] {ECO:0000313|RefSeq:NP_957081.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_957081.1};
RX PubMed=28392072;
RA Thomas-Jinu S., Gordon P.M., Fielding T., Taylor R., Smith B.N.,
RA Snowden V., Blanc E., Vance C., Topp S., Wong C.H., Bielen H.,
RA Williams K.L., McCann E.P., Nicholson G.A., Pan-Vazquez A., Fox A.H.,
RA Bond C.S., Talbot W.S., Blair I.P., Shaw C.E., Houart C.;
RT "Non-nuclear Pool of Splicing Factor SFPQ Regulates Axonal Transcripts
RT Required for Normal Motor Development.";
RL Neuron 94:322-336(2017).
RN [13] {ECO:0000313|RefSeq:NP_957081.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_957081.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; BX001001; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX088710; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX663522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC059637; AAH59637.1; -; mRNA.
DR RefSeq; NP_957081.1; NM_200787.2.
DR STRING; 7955.ENSDARP00000124476; -.
DR PaxDb; 7955-ENSDARP00000111380; -.
DR Ensembl; ENSDART00000149685.3; ENSDARP00000124476.1; ENSDARG00000016676.10.
DR GeneID; 393760; -.
DR KEGG; dre:393760; -.
DR CTD; 393760; -.
DR ZFIN; ZDB-GENE-040426-1757; gnao1a.
DR eggNOG; KOG0082; Eukaryota.
DR HOGENOM; CLU_014184_6_0_1; -.
DR OrthoDB; 2897309at2759; -.
DR TreeFam; TF300673; -.
DR Proteomes; UP000000437; Alternate scaffold 18.
DR Proteomes; UP000000437; Chromosome 18.
DR Bgee; ENSDARG00000016676; Expressed in brain and 38 other cell types or tissues.
DR GO; GO:0005834; C:heterotrimeric G-protein complex; IBA:GO_Central.
DR GO; GO:0051430; F:corticotropin-releasing hormone receptor 1 binding; IBA:GO_Central.
DR GO; GO:0031821; F:G protein-coupled serotonin receptor binding; IBA:GO_Central.
DR GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0031852; F:mu-type opioid receptor binding; IBA:GO_Central.
DR GO; GO:0007188; P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007212; P:dopamine receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00066; G-alpha; 1.
DR Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR001408; Gprotein_alpha_I.
DR InterPro; IPR001019; Gprotein_alpha_su.
DR InterPro; IPR011025; GproteinA_insert.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10218:SF335; GUANINE NUCLEOTIDE-BINDING PROTEIN (G PROTEIN), ALPHA-ACTIVATING ACTIVITY POLYPEPTIDE O, A; 1.
DR Pfam; PF00503; G-alpha; 1.
DR PRINTS; PR00318; GPROTEINA.
DR PRINTS; PR00441; GPROTEINAI.
DR SMART; SM00275; G_alpha; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR PROSITE; PS51882; G_ALPHA; 1.
PE 1: Evidence at protein level;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q6PBP1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
SQ SEQUENCE 354 AA; 39976 MW; 8F3359A00DA53BD0 CRC64;
MGCTLSAEER AALDRSKAIE KNLKEDGITA AKDVKLLLLG AGESGKSTIV KQMKIIHEDG
FSGDDVKQYK PVVYSNTIQS LAAIVRAMDT LGLEYGDKER KADAKMVCDV VSRMEDTEPY
SPELLSAMIR LWSDSGIQEC FSRAREYQLN DSAQYYLDSL DRIGAADYQP TEQDILRTRV
KTTGIVETHF TFKNLHFRLF DVGGQRSERK KWIHCFEDVT AIIFCVALSG YDQVLHEDET
TNRMHESLML FDSICNNKFF IDTSIILFLN KKDLFAEKIK KSPLSICFPE YTGPNTYDDA
AAYIQAQFES KNRSPNKEIY CHMTCATDTG NIQVVFDAVT DIIIANNLRG CGLY
//