ID Q6PBS2_DANRE Unreviewed; 447 AA.
AC Q6PBS2;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 113.
DE SubName: Full=Uncharacterized protein LOC393746 {ECO:0000313|RefSeq:NP_957067.1};
DE SubName: Full=Zgc:73275 {ECO:0000313|EMBL:AAH59604.1};
GN Name=zgc:73275 {ECO:0000313|EMBL:AAH59604.1,
GN ECO:0000313|RefSeq:NP_957067.1};
GN OrderedLocusNames=viml {ECO:0000313|RefSeq:NP_957067.1,
GN ECO:0000313|ZFIN:ZDB-GENE-040426-1743};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH59604.1};
RN [1] {ECO:0000313|EMBL:AAH59604.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Wild-type {ECO:0000313|EMBL:AAH59604.1};
RC TISSUE=Eye {ECO:0000313|EMBL:AAH59604.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_957067.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957067.1};
RX PubMed=23028827;
RA Sager J.J., Torres G.E., Burton E.A.;
RT "The zebrafish homologue of the human DYT1 dystonia gene is widely
RT expressed in CNS neurons but non-essential for early motor system
RT development.";
RL PLoS ONE 7:E45175-E45175(2012).
RN [3] {ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [4] {ECO:0000313|RefSeq:NP_957067.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957067.1};
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [5] {ECO:0000313|RefSeq:NP_957067.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957067.1};
RX PubMed=28242612;
RA Goto H., Kimmey S.C., Row R.H., Matus D.Q., Martin B.L.;
RT "FGF and canonical Wnt signaling cooperate to induce paraxial mesoderm from
RT tailbud neuromesodermal progenitors through regulation of a two-step
RT epithelial to mesenchymal transition.";
RL Development 144:1412-1424(2017).
RN [6] {ECO:0000313|RefSeq:NP_957067.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957067.1};
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [7] {ECO:0000313|RefSeq:NP_957067.1}
RP IDENTIFICATION.
RC STRAIN=Wild-type {ECO:0000313|RefSeq:NP_957067.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Vimentins are class-III intermediate filaments found in
CC various non-epithelial cells, especially mesenchymal cells. Vimentin is
CC attached to the nucleus, endoplasmic reticulum, and mitochondria,
CC either laterally or terminally. {ECO:0000256|ARBA:ARBA00002825}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; BC059604; AAH59604.1; -; mRNA.
DR RefSeq; NP_957067.1; NM_200773.1.
DR GeneID; 393746; -.
DR KEGG; dre:393746; -.
DR CTD; 393746; -.
DR ZFIN; ZDB-GENE-040426-1743; viml.
DR OrthoDB; 4640531at2759; -.
DR PhylomeDB; Q6PBS2; -.
DR Proteomes; UP000000437; Chromosome 2.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR006821; Intermed_filament_DNA-bd.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF5; VIMENTIN; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF04732; Filament_head; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q6PBS2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT DOMAIN 84..392
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 88..236
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 279..370
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 447 AA; 51570 MW; 2525CD72A8714C3B CRC64;
MSTSSYRKRF GDVSRSSALS SRQTFSSSAR TRVSFGASSS PVIYASKSAK VRSSAAMPRL
TSETLDFNLS DALNTEFKAN RLNEKAQMQS LNDRFASYIE KVRFLEQQNK ILSAELEQLR
GQRSSRIADL YEEEMRDLRR QVDLLTTEKT RAEVMRDNLA EDVERLKEKL QDEMLQREDA
ENSMKSFRQD VDNAALARVD LERKVESLQD ELAFLKNLHD EELAELQTQI QGQQVQVEMD
MAKPDLTAAL RDVRLQYENL ASKNIQESED WYKSKFADLT EAANRNNEAL RLAKQETNEY
RRQVQAITCE LDALRGTNES LERQMREMEE NFGMESSGFQ DTIGRLEEDI GNMKDEMARH
LREYQDLLNV KMALDIEIAT YRKLLEGEES RIAAPLPNFS SFNLRETMLE SKLVPENTFT
KKVLIKTIET RDGQVINEST QNHDDLE
//