ID ZFR_DANRE Reviewed; 1074 AA.
AC Q6PCR6;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-APR-2013, entry version 62.
DE RecName: Full=Zinc finger RNA-binding protein;
GN Name=zfr;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Cyprinidae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in postimplantation and gastrulation stages of
CC development. Binds to DNA and RNA (By similarity).
CC -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity).
CC -!- SIMILARITY: Contains 1 DZF domain.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH59198.1; Type=Erroneous initiation;
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; BC059198; AAH59198.1; ALT_INIT; mRNA.
DR IPI; IPI00483929; -.
DR RefSeq; NP_955852.1; NM_199558.1.
DR UniGene; Dr.26724; -.
DR ProteinModelPortal; Q6PCR6; -.
DR STRING; 7955.ENSDARP00000069275; -.
DR GeneID; 321659; -.
DR KEGG; dre:321659; -.
DR CTD; 51663; -.
DR ZFIN; ZDB-GENE-030131-378; zfr.
DR eggNOG; NOG292385; -.
DR HOGENOM; HOG000232147; -.
DR HOVERGEN; HBG108765; -.
DR InParanoid; Q6PCR6; -.
DR KO; K13203; -.
DR OrthoDB; EOG4HX511; -.
DR NextBio; 20807476; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
DR InterPro; IPR006561; DZF.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR003604; Znf_U1.
DR Pfam; PF07528; DZF; 1.
DR SMART; SM00572; DZF; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SMART; SM00451; ZnF_U1; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; UNKNOWN_3.
PE 2: Evidence at transcript level;
KW Complete proteome; Cytoplasm; Developmental protein; DNA-binding;
KW Nucleus; Reference proteome; Repeat; RNA-binding.
FT CHAIN 1 1074 Zinc finger RNA-binding protein.
FT /FTId=PRO_0000312723.
FT DOMAIN 781 1029 DZF.
FT COMPBIAS 35 109 Ala-rich.
FT COMPBIAS 418 488 Ser-rich.
FT COMPBIAS 679 714 Pro-rich.
SQ SEQUENCE 1074 AA; 116523 MW; 3401EB8F7AF55E3C CRC64;
MIPICPVVSF TYVPSRLGED AKMATGNYFG FTHGAGAQYS QQPAAGVAYT HPTTVASYTV
HQAPVAAHTV AAAYAPTAAT VAVARPAPVA VAAAANAAAF GGYQPAHAAT DYGYAQRQPE
VPPPPPPVTS QNYQDSYSYV RSTAPAVAYD SKQYYQQPAA TPAVAAAAAQ PQPTVAESYY
QTAPKTGYSQ GATPYTQTQQ TRQVTVVKPA TPSPATSTFS IYPVSSAVQP VAAAAAASVV
PSYSQSPTYS TNAVTYSGTS YSGYEAAVYS AASSYYQQQQ QQQKQAAVAA AATAAWTGST
FTKKTPFQNK TLKPKQPPKP PQIHYCDVCK ISCAGPQTYK EHLEGQKHKK KEAALKVSQS
SSSSSGGGSS ARGTQNQLRC ELCDVSCTGA DAYAAHIRGA KHQKVVKLHT KLGKPIPSTE
PSVVSQSSTS STAAPNKTSS SNINSSTSTS SNASSSVSAS YLKSGSMAAS AAQGKSSGAN
NVSVNSSSIK KVNTPKINFV GGNKLQTTAS KSDESKADAA KTAQSAASAP AADAKNDMPD
PMSPQSALAA LQSDVQPVGH DYVEEVRNDE GKVIRFHCKL CECSFNDPNA KEMHLKGRRH
RLQYKKKVNP DLQVEVKPSI RARKIQEEKM RKQMQKEEYW RRREEEERWR MEMRRYEEDM
YWRRMEEEQH HWEDRRRMPD GGYPQGPPGP PGLLGVRPGM PIPQPQGPVP PRRPDSSDDR
YVMTKHAAIY PSEDELQAIQ KIVSITERAL KLVSDIITDQ DAGASAKGKE EDKEKKEPPK
DRLLKGVMRV GVLAKGLLLR GDKEVNLVLL CSEKPTKNLL TRIVEHLPKQ LTMVTPEKYE
VKGSIQESAI ILTSCGDPKM QVTITLTSPI IREESSRDGD VTSSMVKDPA DVLDRQKCLD
ALAALRHAKW FQARANGLQS CVIVIRILRD LCQRVPTWSA FPSWAMELLV EKAISSASGP
MSPGDALRRV FECISSGILL SGAPGLIDPC EKNPTDTLAF MEEQQREDIT SSAQFALRLL
AFRQIHKVLG MDPLPQMNSR FNVRNTRKRR RDNSDGADGF EAEGKKDKKD YEGF
//
