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Database: UniProt
Entry: Q6PDK8
LinkDB: Q6PDK8
Original site: Q6PDK8 
ID   DTX4_MOUSE              Reviewed;         616 AA.
AC   Q6PDK8; Q6IS30; Q8BID3;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 2.
DT   03-SEP-2014, entry version 93.
DE   RecName: Full=E3 ubiquitin-protein ligase DTX4;
DE            EC=6.3.2.-;
DE   AltName: Full=Protein deltex-4;
DE            Short=Deltex4;
GN   Name=Dtx4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6; TISSUE=Brain, and Embryo;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 219-616.
RC   STRAIN=C57BL/6J; TISSUE=Head;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   PROTEIN SEQUENCE OF 365-374, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=OF1; TISSUE=Hippocampus;
RA   Lubec G., Sunyer B., Chen W.-Q.;
RL   Submitted (JAN-2009) to UniProtKB.
RN   [4]
RP   IDENTIFICATION, AND TISSUE SPECIFICITY.
RX   PubMed=15684394; DOI=10.1128/MCB.25.4.1437-1445.2005;
RA   Storck S., Delbos F., Stadler N., Thirion-Delalande C., Bernex F.,
RA   Verthuy C., Ferrier P., Weill J.-C., Reynaud C.-A.;
RT   "Normal immune system development in mice lacking the Deltex-1 RING
RT   finger domain.";
RL   Mol. Cell. Biol. 25:1437-1445(2005).
RN   [5]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=16923970; DOI=10.1128/MCB.00149-06;
RA   Lehar S.M., Bevan M.J.;
RT   "T cells develop normally in the absence of both Deltex1 and
RT   Deltex2.";
RL   Mol. Cell. Biol. 26:7358-7371(2006).
CC   -!- FUNCTION: Functions as a ubiquitin ligase protein in vivo,
CC       mediating 'Lys48'-linked polyubiquitination and promoting
CC       degradation of TBK1, targeting to TBK1 requires interaction with
CC       NLRP4 (By similarity). Regulator of Notch signaling, a signaling
CC       pathway involved in cell-cell communications that regulates a
CC       broad spectrum of cell-fate determinations.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Interacts with NLRP4 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- TISSUE SPECIFICITY: Expressed in brain, testis, embryonic
CC       fibroblasts and thymocytes.
CC   -!- DOMAIN: The WWE domains are thought to mediate some protein-
CC       protein interaction, and are frequently found in ubiquitin ligases
CC       (By similarity).
CC   -!- SIMILARITY: Belongs to the Deltex family.
CC   -!- SIMILARITY: Contains 1 RING-type zinc finger.
CC   -!- SIMILARITY: Contains 2 WWE domains.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC39704.1; Type=Frameshift; Positions=266;
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DR   EMBL; BC058647; AAH58647.1; -; mRNA.
DR   EMBL; BC069975; AAH69975.1; -; mRNA.
DR   EMBL; AK086624; BAC39704.1; ALT_FRAME; mRNA.
DR   CCDS; CCDS29631.1; -.
DR   RefSeq; NP_766030.3; NM_172442.3.
DR   UniGene; Mm.247695; -.
DR   ProteinModelPortal; Q6PDK8; -.
DR   SMR; Q6PDK8; 4-164, 387-606.
DR   STRING; 10090.ENSMUSP00000040229; -.
DR   PhosphoSite; Q6PDK8; -.
DR   PRIDE; Q6PDK8; -.
DR   Ensembl; ENSMUST00000045521; ENSMUSP00000040229; ENSMUSG00000039982.
DR   GeneID; 207521; -.
DR   KEGG; mmu:207521; -.
DR   UCSC; uc008guc.2; mouse.
DR   CTD; 23220; -.
DR   MGI; MGI:2672905; Dtx4.
DR   eggNOG; NOG84763; -.
DR   GeneTree; ENSGT00440000035370; -.
DR   HOGENOM; HOG000007352; -.
DR   HOVERGEN; HBG007213; -.
DR   InParanoid; Q6PDK8; -.
DR   KO; K06058; -.
DR   OMA; QSWPVSP; -.
DR   OrthoDB; EOG7J17ZB; -.
DR   PhylomeDB; Q6PDK8; -.
DR   TreeFam; TF325526; -.
DR   Reactome; REACT_196447; IRF3-mediated induction of type I IFN.
DR   Reactome; REACT_196519; Regulation of innate immune responses to cytosolic DNA.
DR   Reactome; REACT_198980; IRF3 mediated activation of type 1 IFN.
DR   Reactome; REACT_199384; Activated NOTCH1 Transmits Signal to the Nucleus.
DR   UniPathway; UPA00143; -.
DR   NextBio; 371957; -.
DR   PRO; PR:Q6PDK8; -.
DR   Bgee; Q6PDK8; -.
DR   CleanEx; MM_DTX4; -.
DR   Genevestigator; Q6PDK8; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR004170; WWE-dom.
DR   InterPro; IPR018123; WWE-dom_subgr.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Pfam; PF02825; WWE; 2.
DR   Pfam; PF13639; zf-RING_2; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00678; WWE; 2.
DR   PROSITE; PS50918; WWE; 2.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytoplasm; Direct protein sequencing; Ligase;
KW   Metal-binding; Notch signaling pathway; Reference proteome; Repeat;
KW   Ubl conjugation pathway; Zinc; Zinc-finger.
FT   CHAIN         1    616       E3 ubiquitin-protein ligase DTX4.
FT                                /FTId=PRO_0000280556.
FT   DOMAIN        1     78       WWE 1.
FT   DOMAIN       79    155       WWE 2.
FT   ZN_FING     406    465       RING-type; atypical.
FT   CONFLICT    272    272       A -> T (in Ref. 1; AAH58647).
SQ   SEQUENCE   616 AA;  66821 MW;  84361BC9A52F6D69 CRC64;
     MLLASAVVVW EWLNEHGRWR PYSPAVSHHI EAVVRAGPRA GGSVVLGQVD SRLAPYIIDL
     QSMNQFRQDT GTLRPVRRNY YDPSSAPGKG VVWEWENDNG SWTPYDMEVG ITIQYAYEKQ
     HPWIDLTSIG FSYIIDFSTM GQINRQTQRQ RRVRRRLDLI YPMVTGTMPK TQSWPVSPGP
     ATSSPAPPCS CPQCVLVMSV KAAVVHGGTG PPAVRKNMAL SGVGKLPQPP GPGAKPLDTT
     GTIRGPGKTA PSQVIRRQVS NAPAGATVGS PASPQGSNRK TGRVALATLN RSNLQRLAIA
     QSRVLIASGV PTVPVKNLNG SSPVNPALAG ITGILMSAAG LPVCLTRPPK LVLHPPPVSK
     SEIKSIPGVS NTSRKTTKKQ AKKGKTPEEV LKKYLQKVRH PPEEDCTICM ERLTAPSGYK
     GPQPTVKPDL VGKLSRCGHI YHIYCLVAMY NNGNKDGSLQ CPTCKTIYGV KTGTQPPGKM
     EYHLIPHSLP GHPDCKTIRI IYSIPPGIQG PEHPNPGKSF SARGFPRHCY LPDSEKGRKV
     LKLLLVAWDR RLIFAIGTSS TTGESDTVIW NEVHHKTEFG SNLTGHGYPD ANYLDNVLAE
     LAAQGISEDS TSHEKD
//
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