ID Q6PT92_SALTM Unreviewed; 381 AA.
AC Q6PT92; A0A0H3TI14; Q4JDD4;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=Beta-lactamase {ECO:0000256|ARBA:ARBA00018879, ECO:0000256|RuleBase:RU361140};
DE EC=3.5.2.6 {ECO:0000256|ARBA:ARBA00012865, ECO:0000256|RuleBase:RU361140};
GN Name=blacmy-2 {ECO:0000313|EMBL:AAT01052.1};
GN Synonyms=bla CMY-2 {ECO:0000313|EMBL:BAD97357.1}, blaCMY-2
GN {ECO:0000313|EMBL:AAX86800.1}, blaCMY2 {ECO:0000313|EMBL:BAN84169.1};
GN ORFNames=ADQ28_20200 {ECO:0000313|EMBL:ECW5426652.1}, ADQ28_26230
GN {ECO:0000313|EMBL:ECW5427807.1}, B4W90_23270
GN {ECO:0000313|EMBL:EDH7471763.1}, B4W90_24800
GN {ECO:0000313|EMBL:EDH7472029.1}, B8Z46_20225
GN {ECO:0000313|EMBL:EDG6486465.1}, B8Z46_24785
GN {ECO:0000313|EMBL:EDG6487318.1}, CVR97_27030
GN {ECO:0000313|EMBL:PJH58950.1}, DD95_18660
GN {ECO:0000313|EMBL:KTZ08474.1}, DNZ37_19050
GN {ECO:0000313|EMBL:EBV1698044.1}, DNZ37_26630
GN {ECO:0000313|EMBL:EBV1699489.1}, F2P00_20735
GN {ECO:0000313|EMBL:ECV9700764.1}, F2P00_24830
GN {ECO:0000313|EMBL:ECV9701541.1}, G4D32_004290
GN {ECO:0000313|EMBL:HAE4606656.1}, G4D32_004934
GN {ECO:0000313|EMBL:HAE4607255.1}, GCZ80_20475
GN {ECO:0000313|EMBL:EDH0975914.1}, GCZ80_23945
GN {ECO:0000313|EMBL:EDH0976566.1}, SE14_04935
GN {ECO:0000313|EMBL:AKH10271.1}, ZY40_23050
GN {ECO:0000313|EMBL:EBO3388325.1}, ZY40_25155
GN {ECO:0000313|EMBL:EBO3388714.1};
OS Salmonella typhimurium.
OG Plasmid pIW759 {ECO:0000313|EMBL:AAT01052.1},
OG Plasmid pNF4656 {ECO:0000313|EMBL:AAT01060.1},
OG Plasmid pS90 {ECO:0000313|EMBL:ABU97163.1},
OG Plasmid pSTHV23035 {ECO:0000313|EMBL:ACV04863.1},
OG Plasmid pYT3 {ECO:0000313|EMBL:BAN84169.1},
OG Plasmid pYU39_IncA/C {ECO:0000313|EMBL:AKH10271.1,
OG ECO:0000313|Proteomes:UP000034636}, and
OG Plasmid unnamed {ECO:0000313|EMBL:AAX86800.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90371 {ECO:0000313|EMBL:AAT01052.1};
RN [1] {ECO:0000313|EMBL:AAT01052.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=pIW759 {ECO:0000313|EMBL:AAT01052.1}, and pNF4656
RC {ECO:0000313|EMBL:AAT01060.1};
RX PubMed=15273090; DOI=10.1128/AAC.48.8.2845-2852.2004;
RA Giles W.P., Benson A.K., Olson M.E., Hutkins R.W., Wichard J.M.,
RA Winokur P.L., Fey P.D.;
RT "DNA sequence analysis of regions surrounding blaCMY-2 from multiple
RT Salmonella plasmid backbones.";
RL Antimicrob. Agents Chemother. 48:2845-2852(2004).
RN [2] {ECO:0000313|EMBL:AAX86800.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=B25 {ECO:0000313|EMBL:AAX86815.1}, L4
RC {ECO:0000313|EMBL:AAX86800.1}, and L9 {ECO:0000313|EMBL:AAX86809.1};
RC PLASMID=unnamed {ECO:0000313|EMBL:AAX86800.1};
RX PubMed=16000441; DOI=10.1128/JCM.43.7.3237-3243.2005;
RA Li W.-C., Huang F.-Y., Liu C.-P., Weng L.-C., Wang N.-Y., Chiu N.-C.,
RA Chiang C.-S.;
RT "Ceftriaxone resistance of nontyphoidal Salmonella enterica isolates in
RT Northern Taiwan attributable to production of CTX-M-14 and CMY-2 beta-
RT lactamases.";
RL J. Clin. Microbiol. 43:3237-3243(2005).
RN [3] {ECO:0000313|EMBL:BAD97357.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=030909 {ECO:0000313|EMBL:BAD97357.1};
RA Ahmed A.M., Shimamoto T.;
RT "Molecular analysis of a mulitdrug-resistant strain of Salmonella enterica
RT serovar Typhimurium isolated in Japan.";
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ABU97163.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=S90 {ECO:0000313|EMBL:ABU97163.1};
RC PLASMID=pS90 {ECO:0000313|EMBL:ABU97163.1};
RX PubMed=18178065; DOI=10.1016/j.ijantimicag.2007.10.023;
RA Zhang Y.N., Peng J., Wang Q., Pei Z.F., Zhang W.J., Niu Z.X.;
RT "Appearance of blaCMY-2)gene-positive Salmonella isolates of pig origin in
RT China.";
RL Int. J. Antimicrob. Agents 31:292-293(2008).
RN [5] {ECO:0000313|EMBL:ACV04863.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=HV23035 {ECO:0000313|EMBL:ACV04863.1};
RC PLASMID=pSTHV23035 {ECO:0000313|EMBL:ACV04863.1};
RX PubMed=20685754; DOI=10.1093/jac/dkq293;
RA Antunes P., Coque T.M., Peixe L.;
RT "Emergence of an IncI? plasmid encoding CMY-2 ?-lactamase associated with
RT the international ST19 OXA-30-producing ?-lactamase Salmonella Typhimurium
RT multidrug-resistant clone.";
RL J. Antimicrob. Chemother. 65:2097-2100(2010).
RN [6] {ECO:0000313|EMBL:BAK19694.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=L-3553 {ECO:0000313|EMBL:BAK19694.1};
RX PubMed=21709089; DOI=10.1128/AAC.00560-11;
RA Shahada F., Sekizuka T., Kuroda M., Kusumoto M., Ohishi D., Matsumoto A.,
RA Okazaki H., Tanaka K., Uchida I., Izumiya H., Watanabe H., Tamamura Y.,
RA Iwata T., Akiba M.;
RT "Characterization of Salmonella enterica Serovar Typhimurium Isolates
RT Harboring a Chromosomally Encoded CMY-2 {beta}-Lactamase Gene Located on a
RT Multidrug Resistance Genomic Island.";
RL Antimicrob. Agents Chemother. 55:4114-4121(2011).
RN [7] {ECO:0000313|EMBL:BAN84169.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=pYT3 {ECO:0000313|EMBL:BAN84169.1};
RX PubMed=24155970; DOI=10.1371/journal.pone.0077644;
RA Tamamura Y., Tanaka K., Akiba M., Kanno T., Hatama S., Ishihara R.,
RA Uchida I.;
RT "Complete Nucleotide Sequences of Virulence-Resistance Plasmids Carried by
RT Emerging Multidrug-Resistant Salmonella enterica Serovar Typhimurium
RT Isolated from Cattle in Hokkaido, Japan.";
RL PLoS ONE 8:e77644-e77644(2013).
RN [8] {ECO:0000313|EMBL:KTZ08474.1, ECO:0000313|Proteomes:UP000054461}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CVM N32045 {ECO:0000313|EMBL:KTZ08474.1,
RC ECO:0000313|Proteomes:UP000054461};
RA Chen Y., Folster J., Ayers S., Kabera C., Li C., Mukherjee S., Lam C.,
RA Zhao S., McDermott P.;
RT "Salmonella Genotype and Phenotype Association.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:AKH10271.1, ECO:0000313|Proteomes:UP000034636}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YU39 {ECO:0000313|EMBL:AKH10271.1,
RC ECO:0000313|Proteomes:UP000034636};
RC PLASMID=pYU39_IncA/C {ECO:0000313|EMBL:AKH10271.1,
RC ECO:0000313|Proteomes:UP000034636};
RX PubMed=26089426;
RA Calva E., Silva C., Zaidi M.B., Sanchez-Flores A., Estrada K., Silva G.G.,
RA Soto-Jimenez L.M., Wiesner M., Fernandez-Mora M., Edwards R.A., Vinuesa P.;
RT "Complete Genome Sequencing of a Multidrug-Resistant and Human-Invasive
RT Salmonella enterica Serovar Typhimurium Strain of the Emerging Sequence
RT Type 213 Genotype.";
RL Genome Announc. 3:e00663-15(2015).
RN [10] {ECO:0000313|EMBL:PJH58950.1, ECO:0000313|Proteomes:UP000228538}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=N029 {ECO:0000313|EMBL:PJH58950.1,
RC ECO:0000313|Proteomes:UP000228538};
RA Sanad Y., Khajanchi B., Deck J., Cox J., Thaker R., Han J., Nayak R.,
RA Foley S.;
RT "Characterization of the Virulence Potential of Salmonella enterica
RT Isolates Carrying Incompatibility Group FIB Plasmids using Caco-2
RT Intestinal Epithelial Cells.";
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:HAE4606656.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Salmonella enterica {ECO:0000313|EMBL:HAE4606656.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [12] {ECO:0000313|EMBL:EBV1698044.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=267728 {ECO:0000313|EMBL:EBV1698044.1};
RA Ashton P.M., Dallman T., Nair S., De Pinna E., Peters T., Grant K.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
RN [13] {ECO:0000313|EMBL:HAE4606656.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Salmonella enterica {ECO:0000313|EMBL:HAE4606656.1};
RG NCBI Pathogen Detection Project;
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [14] {ECO:0000313|EMBL:ECV9700764.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ADRDL-14-19262 {ECO:0000313|EMBL:ECW5426652.1}, AG19-0321
RC {ECO:0000313|EMBL:ECV9700764.1}, FL-NRM148
RC {ECO:0000313|EMBL:EBO3388325.1}, FSIS1700237
RC {ECO:0000313|EMBL:EDG6486465.1}, and FSIS1710628
RC {ECO:0000313|EMBL:EDH7471763.1};
RG GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback;
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN [15] {ECO:0000313|EMBL:EDH0975914.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SAL-19-VL-WA-KY-0005 {ECO:0000313|EMBL:EDH0975914.1};
RG Veterinary Laboratory Investigation and Response Network;
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is a serine beta-lactamase with a substrate
CC specificity for cephalosporins. {ECO:0000256|ARBA:ARBA00003808}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a beta-lactam + H2O = a substituted beta-amino acid;
CC Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627,
CC ChEBI:CHEBI:140347; EC=3.5.2.6;
CC Evidence={ECO:0000256|RuleBase:RU361140};
CC -!- SIMILARITY: Belongs to the class-C beta-lactamase family.
CC {ECO:0000256|ARBA:ARBA00007840, ECO:0000256|RuleBase:RU361140}.
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DR EMBL; AY581205; AAT01052.1; -; Genomic_DNA.
DR EMBL; AY581207; AAT01060.1; -; Genomic_DNA.
DR EMBL; AY899923; AAX86800.1; -; Genomic_DNA.
DR EMBL; AY899926; AAX86809.1; -; Genomic_DNA.
DR EMBL; AY899929; AAX86815.1; -; Genomic_DNA.
DR EMBL; EU113221; ABU97163.1; -; Genomic_DNA.
DR EMBL; GQ398239; ACV04863.1; -; Genomic_DNA.
DR EMBL; CP011429; AKH10271.1; -; Genomic_DNA.
DR EMBL; AB212085; BAD97357.1; -; Genomic_DNA.
DR EMBL; AB571791; BAK19694.1; -; Genomic_DNA.
DR EMBL; AB591424; BAN84169.1; -; Genomic_DNA.
DR EMBL; AAGIEX010000049; EBO3388325.1; -; Genomic_DNA.
DR EMBL; AAGIEX010000093; EBO3388714.1; -; Genomic_DNA.
DR EMBL; AAHEJJ010000021; EBV1698044.1; -; Genomic_DNA.
DR EMBL; AAHEJJ010000098; EBV1699489.1; -; Genomic_DNA.
DR EMBL; AAKUWY010000019; ECV9700764.1; -; Genomic_DNA.
DR EMBL; AAKUWY010000053; ECV9701541.1; -; Genomic_DNA.
DR EMBL; AAKWTQ010000024; ECW5426652.1; -; Genomic_DNA.
DR EMBL; AAKWTQ010000083; ECW5427807.1; -; Genomic_DNA.
DR EMBL; AAMEWS010000019; EDG6486465.1; -; Genomic_DNA.
DR EMBL; AAMEWS010000054; EDG6487318.1; -; Genomic_DNA.
DR EMBL; AAMGJM010000018; EDH0975914.1; -; Genomic_DNA.
DR EMBL; AAMGJM010000040; EDH0976566.1; -; Genomic_DNA.
DR EMBL; AAMIRC010000034; EDH7471763.1; -; Genomic_DNA.
DR EMBL; AAMIRC010000061; EDH7472029.1; -; Genomic_DNA.
DR EMBL; DAARZQ010000033; HAE4606656.1; -; Genomic_DNA.
DR EMBL; DAARZQ010000083; HAE4607255.1; -; Genomic_DNA.
DR EMBL; JYVU01000054; KTZ08474.1; -; Genomic_DNA.
DR EMBL; PHGX01000118; PJH58950.1; -; Genomic_DNA.
DR RefSeq; WP_000976514.1; NZ_WIDF01000020.1.
DR RefSeq; YP_008574733.1; NC_022372.1.
DR SMR; Q6PT92; -.
DR MEROPS; S12.006; -.
DR GeneID; 39514982; -.
DR PATRIC; fig|59201.158.peg.5154; -.
DR PATRIC; fig|90371.689.peg.1657; -.
DR PHI-base; PHI:6133; -.
DR Proteomes; UP000034636; Plasmid pYU39_IncA/C.
DR Proteomes; UP000054461; Unassembled WGS sequence.
DR Proteomes; UP000228538; Unassembled WGS sequence.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IEA:InterPro.
DR GO; GO:0008800; F:beta-lactamase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004180; F:carboxypeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0017001; P:antibiotic catabolic process; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR InterPro; IPR001466; Beta-lactam-related.
DR InterPro; IPR012338; Beta-lactam/transpept-like.
DR InterPro; IPR001586; Beta-lactam_class-C_AS.
DR PANTHER; PTHR46825:SF8; BETA-LACTAMASE-RELATED; 1.
DR PANTHER; PTHR46825; D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH; 1.
DR Pfam; PF00144; Beta-lactamase; 1.
DR SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR PROSITE; PS00336; BETA_LACTAMASE_C; 1.
PE 3: Inferred from homology;
KW Antibiotic resistance {ECO:0000256|RuleBase:RU361140};
KW Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW Hydrolase {ECO:0000256|RuleBase:RU361140};
KW Membrane {ECO:0000256|ARBA:ARBA00022692};
KW Plasmid {ECO:0000313|EMBL:AAT01052.1};
KW Protease {ECO:0000256|ARBA:ARBA00022645}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..381
FT /note="Beta-lactamase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014106575"
FT DOMAIN 32..380
FT /note="Beta-lactamase-related"
FT /evidence="ECO:0000259|Pfam:PF00144"
SQ SEQUENCE 381 AA; 42003 MW; 8C30E62E52DFC311 CRC64;
MMKKSLCCAL LLTASFSTFA AAKTEQQIAD IVNRTITPLM QEQAIPGMAV AVIYQGKPYY
FTWGKADIAN NHPVTQQTLF ELGSVSKTFN GVLGGDAIAR GEIKLSDPVT KYWPELTGKQ
WQGIRLLHLA TYTAGGLPLQ IPDDVRDKAA LLHFYQNWQP QWTPGAKRLY ANSSIGLFGA
LAVKPSGMSY EEAMTRRVLQ PLKLAHTWIT VPQNEQKDYA WGYREGKPVH VSPGQLDAEA
YGVKSSVIDM ARWVQANMDA SHVQEKTLQQ GIALAQSRYW RIGDMYQGLG WEMLNWPLKA
DSIINGSDSK VALAALPAVE VNPPAPAVKA SWVHKTGSTG GFGSYVAFVP EKNLGIVMLA
NKSYPNPVRV EAAWRILEKL Q
//
