ID Q6PVC0_DROSI Unreviewed; 604 AA.
AC Q6PVC0;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Period circadian protein {ECO:0000256|ARBA:ARBA00040849};
DE Flags: Fragment;
GN Name=per {ECO:0000313|FlyBase:FBgn0012888};
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000313|EMBL:AAS88950.1};
RN [1] {ECO:0000313|EMBL:AAS88950.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RU35 {ECO:0000313|EMBL:AAS88950.1};
RX PubMed=15288072; DOI=10.1016/j.ympev.2004.03.013;
RA Dean M.D., Ballard J.W.O.;
RT "Linking phylogenetics with population genetics to reconstruct the
RT geographic origin of a species.";
RL Mol. Phylogenet. Evol. 32:998-1009(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AY575830; AAS88950.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6PVC0; -.
DR FlyBase; FBgn0012888; Dsim\per.
DR GO; GO:0044297; C:cell body; IEA:EnsemblMetazoa.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:EnsemblMetazoa.
DR GO; GO:0060086; P:circadian temperature homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0007620; P:copulation; IEA:EnsemblMetazoa.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
DR GO; GO:0008062; P:eclosion rhythm; IEA:EnsemblMetazoa.
DR GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IEA:EnsemblMetazoa.
DR GO; GO:0045475; P:locomotor rhythm; IEA:EnsemblMetazoa.
DR GO; GO:0007616; P:long-term memory; IEA:EnsemblMetazoa.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR GO; GO:2000678; P:negative regulation of transcription regulatory region DNA binding; IEA:EnsemblMetazoa.
DR GO; GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; IEA:EnsemblMetazoa.
DR GO; GO:1904059; P:regulation of locomotor rhythm; IEA:EnsemblMetazoa.
DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:EnsemblMetazoa.
DR GO; GO:0006979; P:response to oxidative stress; IEA:EnsemblMetazoa.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR Gene3D; 1.20.5.770; Single helix bin; 1.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR PANTHER; PTHR11269; PERIOD CIRCADIAN PROTEIN; 1.
DR PANTHER; PTHR11269:SF16; PERIOD CIRCADIAN PROTEIN; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 243..292
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 394..442
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..93
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 118..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAS88950.1"
FT NON_TER 604
FT /evidence="ECO:0000313|EMBL:AAS88950.1"
SQ SEQUENCE 604 AA; 65863 MW; 60A65D6705CE58FA CRC64;
ESTESTHNTK VSDSAYSNSC SNSQSQRSGS SKSRLSGSHS SGSSGYGGKP STQASSSDMI
IKRNKDKSRK KKKNKGAGQG AGQAQTLISA STSLEGRDEE KPRPSGTGCV EQQICRELQD
QQHGEDHSEP QATEQLQQEE EDQSGSESEA DRVEGVAKSE AAQSFPIPSP LSVTIVPPSM
GGCGGVGHAA GLDSGLAKFD KTWEAGPGKL ESMTGVGAAA AGTGQRGERV KEDSFCCVIS
MHDGIVLYTT PSITDVLGYP RDMWLGRSFI DFVHLKDRAT FASQITTGIP IAESRGSVPK
DAKSTFCVML RRYRGLKSGG FGVIGRPVSY EPFRLGLTFR EAPEEARPDN YMVSNGTNML
LVICATPIKS SYKVPDEILS QKSPKFAIRH TATGIISHVD SAAVSALGYL PQDLIGRSIM
DFYHHEDLSV MKETYETVMK KGQTAGASFC SKAYRFLIQN GCYVLLETEW TSFVNPWSRK
LEFVVGHHRV FQGPKQCNVF EAAPTCKLKI SEEAQSRNTR IKEDIVKRLA ETVSRPSDTV
KQEVSRRCQA LASFMETLMD EVSRADLKLE LPHENELTVS ERDSVMLGEI SPHHDYYDSK
SSTE
//
