ID Q6PW34_RAT Unreviewed; 1299 AA.
AC Q6PW34; D3ZXM9;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 152.
DE SubName: Full=Neuronal cell adhesion molecule long isoform Nc17 {ECO:0000313|EMBL:AAS89825.1};
GN Name=Nrcam {ECO:0000313|RGD:3209};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116 {ECO:0000313|EMBL:AAS89825.1};
RN [1] {ECO:0000313|EMBL:AAS89825.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Sprague-Dawley {ECO:0000313|EMBL:AAS89825.1};
RA Liu Q.-R., Uhl G.R.;
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAS89825.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Sprague-Dawley {ECO:0000313|EMBL:AAS89825.1};
RX PubMed=16123759; DOI=10.1038/sj.npp.1300855;
RA Ishiguro H., Liu Q.R., Gong J.P., Hall F.S., Ujike H., Morales M.,
RA Sakurai T., Grumet M., Uhl G.R.;
RT "NrCAM in Addiction Vulnerability: Positional Cloning, Drug-Regulation,
RT Haplotype-Specific Expression, and Altered Drug Reward in Knockout Mice.";
RL Neuropsychopharmacology 0:0-0(2005).
RN [3] {ECO:0007829|PubMed:16641100}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=16641100; DOI=10.1073/pnas.0600895103;
RA Hoffert J.D., Pisitkun T., Wang G., Shen R.F., Knepper M.A.;
RT "Quantitative phosphoproteomics of vasopressin-sensitive renal cells:
RT regulation of aquaporin-2 phosphorylation at two sites.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:7159-7164(2006).
RN [4] {ECO:0007829|PubMed:22673903}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
RN [5] {ECO:0007829|PubMed:24090084}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=24090084;
RA Parker B.L., Thaysen-Andersen M., Solis N., Scott N.E., Larsen M.R.,
RA Graham M.E., Packer N.H., Cordwell S.J.;
RT "Site-specific glycan-peptide analysis for determination of N-glycoproteome
RT heterogeneity.";
RL J. Proteome Res. 12:5791-5800(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR EMBL; AY574277; AAS89825.1; -; mRNA.
DR RefSeq; NP_037282.1; NM_013150.1.
DR SMR; Q6PW34; -.
DR GeneID; 497815; -.
DR KEGG; rno:497815; -.
DR CTD; 4897; -.
DR RGD; 3209; Nrcam.
DR VEuPathDB; HostDB:ENSRNOG00000004067; -.
DR OrthoDB; 2912783at2759; -.
DR TreeFam; TF351098; -.
DR Bgee; ENSRNOG00000004067; Expressed in frontal cortex and 15 other cell types or tissues.
DR ExpressionAtlas; Q6PW34; baseline and differential.
DR Genevisible; Q6PW34; RN.
DR GO; GO:0030424; C:axon; IEA:UniProt.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 5.
DR CDD; cd05874; IgI_NrCAM; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF15; NEURONAL CELL ADHESION MOLECULE; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 6.
DR PROSITE; PS00290; IG_MHC; 1.
PE 1: Evidence at protein level;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
SQ SEQUENCE 1299 AA; 143146 MW; 9176A35751E53455 CRC64;
MPKKKPLSAG RAPLFLFLCQ MISALDVPLD PKLLDDLVQP PTITQQSPKD YIIDPRENIV
IQCEAKGKPP PSFSWTRNGT HFDIDKDPLV TMKPGSGTLV INIMSEGKAE TYEGVYQCTA
RNERGAAVSN NIVVRPSRSP LWTKERLEPI ILRSGQSLVL PCRPPIGLPP AIIFWMDNSF
QRLPQSERVS QGLNGDLYFS NVLPEDTRED YICYARFNHT QTIQQKQPIS LKVISVDELN
DTIAANLSDT EFYGAKSSKE RPPTFLTPEG NESHKEELRG NVLSLECIAE GLPTPVIYWI
KEDGTLPVNR TFYRNFKKTL QIIHVSEADS GNYQCIAKNA LGAVHHTISV TVKAAPYWIV
APHNLVLSPG ENGTLICRAN GNPKPRISWL TNGVPVEIAL DDPSRKIDGD TIMFSNVQES
SSAVYQCNAS NKYGYLLANA FVNVLAEPPR ILTSANTLYQ VIANRPALLD CAFFGSPMPT
IEWFKGTKGS ALHEDIYVLH DNGTLEIPVA QKDSTGTYTC VARNKLGMAK NEVHLEIKDP
TRFIKQPEYA VVQRGSKVSF ECKVKHDHTL IPTILWLKDN GELPNDERFS VDKDHLVVSD
VKDEDGGTYT CAANTTLDSV SASAVLRVVA PTPTPAPIYD VPNPPFDLEL TNQLDKSVQL
TWTPGDDNNS PITKFIIEYE DAMHEAGLWR HQAEVSGTQT TAQLKLSPYV NYSFRVMAEN
SIGRSVPSEA SEQYLTKAAE PDQNPTAVEG LGTEPDNLVI TWKPLNGFQS NGPGLQYKVS
WRQKDGDDEW TSVVVANVSK YIVSGTPTFV PYLIKVQALN DVGFAPEPAA VMGHSGEDLP
MVAPGNVRVS VVNSTLAEAH WDPVPPKSVR GHLQGYRIYY WKAQSSSKRN RRHIEKKILT
FQGSKTHGML PGLQPYSHYV LNVRVVNGKG EGPASADRGF HTPEGVPSAP SSLKIVNPTL
DSLTLEWDPP SHPNGILTEY ILKYQPINST HELGPLVDLK IPANKTRWTL KNLNFSTRYK
FYFYAQTSVG SGSQITEEAI TTVDEAGILP PDVGAGKVRA VSPRIGNVTA AAAETYANIS
WEYEGPEHVK FYVEYGVAGS KEEWRKEIVN GSRSFFGLKG LMPGTAYKVR VGAEGDSGFV
SSEDVFETGP AMASRQVDIA TQGWFIGLMC AVALLILILL IVCFIRRNKG GKYPVKEKED
AHADPEIQPM KEDDGTFGEY SDAEDHKPLK KGSRTPSDRT VKKEDSDDSL VDYGEGVNGQ
FNEDGSFIGQ YSGKKEKEPA EGNESSEAPS PVNAMNSFV
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