ID Q6Q479_PSEAI Unreviewed; 263 AA.
AC Q6Q479;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 91.
DE RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252, ECO:0000256|PIRNR:PIRNR000819};
DE EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126, ECO:0000256|PIRNR:PIRNR000819};
GN Name=aadA2 {ECO:0000313|EMBL:AAS48664.1};
OS Pseudomonas aeruginosa.
OG Plasmid R {ECO:0000313|EMBL:AGX26769.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=287 {ECO:0000313|EMBL:AAS48664.1};
RN [1] {ECO:0000313|EMBL:AAS48664.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15616334; DOI=10.1128/AAC.49.1.451-453.2005;
RA Quinteira S., Sousa J.C., Peixe L.;
RT "Characterization of In100, a new integron carrying a metallo-{beta}-
RT lactamase and a carbenicillinase, from Pseudomonas aeruginosa.";
RL Antimicrob. Agents Chemother. 49:451-453(2005).
RN [2] {ECO:0000313|EMBL:ABB00020.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16870030; DOI=10.1017/S095026880600700X;
RA Caetano T., Ferreira S., Mondego A.P., Correia A., Mendo S.;
RT "In99, an In100-related integron, its occurrence and prevalence in clinical
RT Pseudomonas aeruginosa strains from a central region of Portugal.";
RL Epidemiol. Infect. 135:502-504(2007).
RN [3] {ECO:0000313|EMBL:ABN10337.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=YMC 05/5/1785 {ECO:0000313|EMBL:ABN10337.1};
RA Yum J.H., Shin H.B., Roh K.H., Yong D., Lee K., Chong Y.;
RT "blaVIM-2 metallo-beta-lactamase gene-containing integron in an Pseudomonas
RT aeruginosa from a clinical specimen.";
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CAI43350.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bpoe636 {ECO:0000313|EMBL:CAI43350.1};
RA Colinon C., Jocktane D., Brothier E., Rossolini G.M., Cournoyer B.,
RA Nazaret S.;
RT "Genetic analyses of Pseudomonas aeruginosa isolated from healthy captive
RT snakes: evidence of high inter- and intrasite dissemination and occurrence
RT of antibiotic resistance genes.";
RL Environ. Microbiol. 12:716-729(2009).
RN [5] {ECO:0000313|EMBL:ABN13424.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PaTBIZP2 {ECO:0000313|EMBL:ABN13424.1};
RA Budak F., Kasap M., Vahaboglu H.;
RT "Pseudomonas aeruginosa clinical isolate (PaTBIZP2) class I Integron.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:ACO53365.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PA466 {ECO:0000313|EMBL:ACO53365.1};
RA Yan L., Wu W.;
RT "Identification and characterization of class 1 integrons in imipenem-
RT resistant Pseudomonas aeruginas.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:ACY78396.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Pae1-2 {ECO:0000313|EMBL:ACY78396.1};
RA Huang J.Y., Wu A.W., Zheng L.;
RT "Multi-drug resistant Pseudomonas aeruginosa integron research.";
RL Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:ADF28281.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NF812058 {ECO:0000313|EMBL:ADI49239.1}, NF813075
RC {ECO:0000313|EMBL:ADF28281.1}, and NF902524
RC {ECO:0000313|EMBL:ADK11240.1};
RA Wang F., Rui Y.;
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:ADF48911.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=P.32 {ECO:0000313|EMBL:ADF28699.1}, and PA16
RC {ECO:0000313|EMBL:ADF48911.1};
RA Peng C.-F., Hsiao K.-Y.;
RT "Analysis of class I integron and antibiotic-resistant gene cassettes in
RT clinical isolates of Pseudomonas aeruginosa.";
RL Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:AEM36721.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=K-88 {ECO:0000313|EMBL:AEM36721.1};
RA Kuzhelnaya E.N., Pryamchuk S.D., Fursova N.K., Svetoch E.A.;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:AER70352.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NF812352 {ECO:0000313|EMBL:AER70352.1};
RA Wu K.H., Sun J.J., Rui Y.Y.;
RT "Pseudomonas aeruginosa variable region of class 1 integron containing aadB
RT and aadA2 cassettes.";
RL Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:AGX26769.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=KARMS08249 {ECO:0000313|EMBL:AGX26769.1};
RC PLASMID=R {ECO:0000313|EMBL:AGX26769.1};
RA Bae I.K., Lee H., Jeong S.H., Lee K.;
RT "beta-Lactamases with hydrolytic activities against extended-spectrum beta-
RT lactams in Pseudomonas aeruginosa from Korea.";
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
RN [13] {ECO:0000313|EMBL:AIA09255.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=M-B10D {ECO:0000313|EMBL:AIA09255.1};
RA Liang J., Lin M.;
RT "Investigation in the Spread of Antibiotic-resistant Bacteria in the
RT Jiulong River.";
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC Evidence={ECO:0000256|ARBA:ARBA00001672,
CC ECO:0000256|PIRNR:PIRNR000819};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC Evidence={ECO:0000256|ARBA:ARBA00035070,
CC ECO:0000256|PIRNR:PIRNR000819};
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DR EMBL; AY560837; AAS48664.1; -; Genomic_DNA.
DR EMBL; DQ219465; ABB00020.1; -; Genomic_DNA.
DR EMBL; EF207717; ABN10337.1; -; Genomic_DNA.
DR EMBL; EF368053; ABN13424.1; -; Genomic_DNA.
DR EMBL; FJ817423; ACO53365.1; -; Genomic_DNA.
DR EMBL; GU122165; ACY78396.1; -; Genomic_DNA.
DR EMBL; GU906255; ADF28281.1; -; Genomic_DNA.
DR EMBL; GU934609; ADF28699.1; -; Genomic_DNA.
DR EMBL; GU966684; ADF48911.1; -; Genomic_DNA.
DR EMBL; HM106459; ADI49239.1; -; Genomic_DNA.
DR EMBL; HM175863; ADK11240.1; -; Genomic_DNA.
DR EMBL; JN003858; AEM36721.1; -; Genomic_DNA.
DR EMBL; JN119852; AER70352.1; -; Genomic_DNA.
DR EMBL; KF257849; AGX26769.1; -; Genomic_DNA.
DR EMBL; KJ723459; AIA09255.1; -; Genomic_DNA.
DR EMBL; AJ867811; CAI43350.1; -; Genomic_DNA.
DR RefSeq; WP_001261740.1; NZ_QORA01000378.1.
DR AlphaFoldDB; Q6Q479; -.
DR PATRIC; fig|287.1491.peg.5524; -.
DR GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd05403; NT_KNTase_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR024172; AadA/Aad9.
DR InterPro; IPR025184; AadA_C.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR Pfam; PF13427; AadA_C; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW ECO:0000256|PIRNR:PIRNR000819};
KW ATP-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000819,
KW ECO:0000313|EMBL:ACY78396.1}; Plasmid {ECO:0000313|EMBL:AGX26769.1};
KW Transferase {ECO:0000256|PIRNR:PIRNR000819, ECO:0000313|EMBL:AAS48664.1}.
FT DOMAIN 28..97
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 153..254
FT /note="Adenylyltransferase AadA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13427"
SQ SEQUENCE 263 AA; 29549 MW; D7FB27184F7D6B26 CRC64;
MRVAVTIEIS NQLSEVLSVI ERHLESTLLA VHLYGSAVDG GLKPYSDIDL LVTVAVKLDE
TTRRALLNDL MEASAFPGES ETLRAIEVTL VVHDDIIPWR YPAKRELQFG EWQRNDILAG
IFEPAMIDID LAILLTKARE HSVALVGPAA EEFFDPVPEQ DLFEALRETL KLWNSQPDWA
GDERNVVLTL SRIWYSAITG KIAPKDVAAD WAIKRLPAQY QPVLLEAKQA YLGQKEDHLA
SRADHLEEFI RFVKGEIIKS VGK
//