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Database: UniProt
Entry: Q6Q479_PSEAI
LinkDB: Q6Q479_PSEAI
Original site: Q6Q479_PSEAI 
ID   Q6Q479_PSEAI            Unreviewed;       263 AA.
AC   Q6Q479;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 91.
DE   RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252, ECO:0000256|PIRNR:PIRNR000819};
DE            EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126, ECO:0000256|PIRNR:PIRNR000819};
GN   Name=aadA2 {ECO:0000313|EMBL:AAS48664.1};
OS   Pseudomonas aeruginosa.
OG   Plasmid R {ECO:0000313|EMBL:AGX26769.1}.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=287 {ECO:0000313|EMBL:AAS48664.1};
RN   [1] {ECO:0000313|EMBL:AAS48664.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=15616334; DOI=10.1128/AAC.49.1.451-453.2005;
RA   Quinteira S., Sousa J.C., Peixe L.;
RT   "Characterization of In100, a new integron carrying a metallo-{beta}-
RT   lactamase and a carbenicillinase, from Pseudomonas aeruginosa.";
RL   Antimicrob. Agents Chemother. 49:451-453(2005).
RN   [2] {ECO:0000313|EMBL:ABB00020.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16870030; DOI=10.1017/S095026880600700X;
RA   Caetano T., Ferreira S., Mondego A.P., Correia A., Mendo S.;
RT   "In99, an In100-related integron, its occurrence and prevalence in clinical
RT   Pseudomonas aeruginosa strains from a central region of Portugal.";
RL   Epidemiol. Infect. 135:502-504(2007).
RN   [3] {ECO:0000313|EMBL:ABN10337.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=YMC 05/5/1785 {ECO:0000313|EMBL:ABN10337.1};
RA   Yum J.H., Shin H.B., Roh K.H., Yong D., Lee K., Chong Y.;
RT   "blaVIM-2 metallo-beta-lactamase gene-containing integron in an Pseudomonas
RT   aeruginosa from a clinical specimen.";
RL   Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:CAI43350.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bpoe636 {ECO:0000313|EMBL:CAI43350.1};
RA   Colinon C., Jocktane D., Brothier E., Rossolini G.M., Cournoyer B.,
RA   Nazaret S.;
RT   "Genetic analyses of Pseudomonas aeruginosa isolated from healthy captive
RT   snakes: evidence of high inter- and intrasite dissemination and occurrence
RT   of antibiotic resistance genes.";
RL   Environ. Microbiol. 12:716-729(2009).
RN   [5] {ECO:0000313|EMBL:ABN13424.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PaTBIZP2 {ECO:0000313|EMBL:ABN13424.1};
RA   Budak F., Kasap M., Vahaboglu H.;
RT   "Pseudomonas aeruginosa clinical isolate (PaTBIZP2) class I Integron.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:ACO53365.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PA466 {ECO:0000313|EMBL:ACO53365.1};
RA   Yan L., Wu W.;
RT   "Identification and characterization of class 1 integrons in imipenem-
RT   resistant Pseudomonas aeruginas.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:ACY78396.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Pae1-2 {ECO:0000313|EMBL:ACY78396.1};
RA   Huang J.Y., Wu A.W., Zheng L.;
RT   "Multi-drug resistant Pseudomonas aeruginosa integron research.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:ADF28281.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NF812058 {ECO:0000313|EMBL:ADI49239.1}, NF813075
RC   {ECO:0000313|EMBL:ADF28281.1}, and NF902524
RC   {ECO:0000313|EMBL:ADK11240.1};
RA   Wang F., Rui Y.;
RL   Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:ADF48911.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=P.32 {ECO:0000313|EMBL:ADF28699.1}, and PA16
RC   {ECO:0000313|EMBL:ADF48911.1};
RA   Peng C.-F., Hsiao K.-Y.;
RT   "Analysis of class I integron and antibiotic-resistant gene cassettes in
RT   clinical isolates of Pseudomonas aeruginosa.";
RL   Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:AEM36721.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=K-88 {ECO:0000313|EMBL:AEM36721.1};
RA   Kuzhelnaya E.N., Pryamchuk S.D., Fursova N.K., Svetoch E.A.;
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [11] {ECO:0000313|EMBL:AER70352.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NF812352 {ECO:0000313|EMBL:AER70352.1};
RA   Wu K.H., Sun J.J., Rui Y.Y.;
RT   "Pseudomonas aeruginosa variable region of class 1 integron containing aadB
RT   and aadA2 cassettes.";
RL   Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0000313|EMBL:AGX26769.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KARMS08249 {ECO:0000313|EMBL:AGX26769.1};
RC   PLASMID=R {ECO:0000313|EMBL:AGX26769.1};
RA   Bae I.K., Lee H., Jeong S.H., Lee K.;
RT   "beta-Lactamases with hydrolytic activities against extended-spectrum beta-
RT   lactams in Pseudomonas aeruginosa from Korea.";
RL   Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
RN   [13] {ECO:0000313|EMBL:AIA09255.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=M-B10D {ECO:0000313|EMBL:AIA09255.1};
RA   Liang J., Lin M.;
RT   "Investigation in the Spread of Antibiotic-resistant Bacteria in the
RT   Jiulong River.";
RL   Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC         Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC         Evidence={ECO:0000256|ARBA:ARBA00001672,
CC         ECO:0000256|PIRNR:PIRNR000819};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC         Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC         Evidence={ECO:0000256|ARBA:ARBA00035070,
CC         ECO:0000256|PIRNR:PIRNR000819};
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DR   EMBL; AY560837; AAS48664.1; -; Genomic_DNA.
DR   EMBL; DQ219465; ABB00020.1; -; Genomic_DNA.
DR   EMBL; EF207717; ABN10337.1; -; Genomic_DNA.
DR   EMBL; EF368053; ABN13424.1; -; Genomic_DNA.
DR   EMBL; FJ817423; ACO53365.1; -; Genomic_DNA.
DR   EMBL; GU122165; ACY78396.1; -; Genomic_DNA.
DR   EMBL; GU906255; ADF28281.1; -; Genomic_DNA.
DR   EMBL; GU934609; ADF28699.1; -; Genomic_DNA.
DR   EMBL; GU966684; ADF48911.1; -; Genomic_DNA.
DR   EMBL; HM106459; ADI49239.1; -; Genomic_DNA.
DR   EMBL; HM175863; ADK11240.1; -; Genomic_DNA.
DR   EMBL; JN003858; AEM36721.1; -; Genomic_DNA.
DR   EMBL; JN119852; AER70352.1; -; Genomic_DNA.
DR   EMBL; KF257849; AGX26769.1; -; Genomic_DNA.
DR   EMBL; KJ723459; AIA09255.1; -; Genomic_DNA.
DR   EMBL; AJ867811; CAI43350.1; -; Genomic_DNA.
DR   RefSeq; WP_001261740.1; NZ_QORA01000378.1.
DR   AlphaFoldDB; Q6Q479; -.
DR   PATRIC; fig|287.1491.peg.5524; -.
DR   GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR   GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd05403; NT_KNTase_like; 1.
DR   Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR   InterPro; IPR024172; AadA/Aad9.
DR   InterPro; IPR025184; AadA_C.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR   Pfam; PF13427; AadA_C; 1.
DR   Pfam; PF01909; NTP_transf_2; 1.
DR   PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR   SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE   4: Predicted;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW   ECO:0000256|PIRNR:PIRNR000819};
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR000819};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000819};
KW   Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000819,
KW   ECO:0000313|EMBL:ACY78396.1}; Plasmid {ECO:0000313|EMBL:AGX26769.1};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000819, ECO:0000313|EMBL:AAS48664.1}.
FT   DOMAIN          28..97
FT                   /note="Polymerase nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF01909"
FT   DOMAIN          153..254
FT                   /note="Adenylyltransferase AadA C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13427"
SQ   SEQUENCE   263 AA;  29549 MW;  D7FB27184F7D6B26 CRC64;
     MRVAVTIEIS NQLSEVLSVI ERHLESTLLA VHLYGSAVDG GLKPYSDIDL LVTVAVKLDE
     TTRRALLNDL MEASAFPGES ETLRAIEVTL VVHDDIIPWR YPAKRELQFG EWQRNDILAG
     IFEPAMIDID LAILLTKARE HSVALVGPAA EEFFDPVPEQ DLFEALRETL KLWNSQPDWA
     GDERNVVLTL SRIWYSAITG KIAPKDVAAD WAIKRLPAQY QPVLLEAKQA YLGQKEDHLA
     SRADHLEEFI RFVKGEIIKS VGK
//
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