ID Q6Q8L8_9RETR Unreviewed; 216 AA.
AC Q6Q8L8;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE RecName: Full=dUTP diphosphatase {ECO:0000256|ARBA:ARBA00012379};
DE EC=3.6.1.23 {ECO:0000256|ARBA:ARBA00012379};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AAS67758.1};
OS Feline immunodeficiency virus.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11673 {ECO:0000313|EMBL:AAS67758.1};
RN [1] {ECO:0000313|EMBL:AAS67758.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FIV-Ple {ECO:0000313|EMBL:AAS67758.1};
RX PubMed=15016897; DOI=10.1128/JVI.78.7.3777-3791.2004;
RA Troyer J.L., Pecon-Slattery J., Roelke M.E., Black L., Packer C.,
RA O'Brien S.J.;
RT "Patterns of feline immunodeficiency virus multiple infection and genome
RT divergence in a free-ranging population of African lions.";
RL J. Virol. 78:3777-3791(2004).
RN [2] {ECO:0000313|EMBL:AAS67758.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FIV-Ple {ECO:0000313|EMBL:AAS67758.1};
RX PubMed=18989457; DOI=10.1371/journal.pgen.1000251;
RA Antunes A., Troyer J.L., Roelke M.E., Pecon-Slattery J., Packer C.,
RA Winterbach C., Winterbach H., Hemson G., Frank L., Stander P., Siefert L.,
RA Driciru M., Funston P.J., Alexander K.A., Prager K.C., Mills G., Wildt D.,
RA Bush M., O'Brien S.J., Johnson W.E.;
RT "The evolutionary dynamics of the lion Panthera leo revealed by host and
RT viral population genomics.";
RL PLoS Genet. 4:E1000251-E1000251(2008).
CC -!- SIMILARITY: Belongs to the dUTPase family.
CC {ECO:0000256|ARBA:ARBA00006581}.
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DR EMBL; AY552646; AAS67758.1; -; Genomic_DNA.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0004170; F:dUTP diphosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006226; P:dUMP biosynthetic process; IEA:InterPro.
DR GO; GO:0046081; P:dUTP catabolic process; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR CDD; cd07557; trimeric_dUTPase; 1.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 2.70.40.10; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR008181; dUTPase.
DR InterPro; IPR029054; dUTPase-like.
DR InterPro; IPR036157; dUTPase-like_sf.
DR InterPro; IPR033704; dUTPase_trimeric.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR11241; DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE; 1.
DR PANTHER; PTHR11241:SF0; DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE; 1.
DR Pfam; PF00692; dUTPase; 1.
DR Pfam; PF02022; Integrase_Zn; 1.
DR SUPFAM; SSF51283; dUTPase-like; 1.
DR SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50876; ZF_INTEGRASE; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750};
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022750};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00450}.
FT DOMAIN 109..150
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS50876"
FT DOMAIN 152..216
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAS67758.1"
FT NON_TER 216
FT /evidence="ECO:0000313|EMBL:AAS67758.1"
SQ SEQUENCE 216 AA; 23907 MW; C2097C02AF454109 CRC64;
PGEVRIIPTG VKLMLPKGHW GLVIGKSSIG KQGLDVLGGV IDEGYRGEIG VIMINLNRKS
ITLKEKQKIA QLIIIPCKHE PLEQGEIKLD SARGEGGYGS TGAFASWIDK IEEAEINHEK
FHSDPEYLRT EFGLPKQVAE EIKRKCPLCI VQGEQPMGKL RIGPGIWQAD CTHLEGKIIL
VAVNTESGYI WARIMPQETA DNTVKLFLQL ISEHHV
//
