ID Q6Q8P0_9RETR Unreviewed; 216 AA.
AC Q6Q8P0;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=dUTP diphosphatase {ECO:0000256|ARBA:ARBA00012379};
DE EC=3.6.1.23 {ECO:0000256|ARBA:ARBA00012379};
DE Flags: Fragment;
GN Name=pol {ECO:0000313|EMBL:AAS67736.1};
OS Feline immunodeficiency virus.
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11673 {ECO:0000313|EMBL:AAS67736.1};
RN [1] {ECO:0000313|EMBL:AAS67736.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FIV-Ple {ECO:0000313|EMBL:AAS67736.1};
RX PubMed=15016897; DOI=10.1128/JVI.78.7.3777-3791.2004;
RA Troyer J.L., Pecon-Slattery J., Roelke M.E., Black L., Packer C.,
RA O'Brien S.J.;
RT "Patterns of feline immunodeficiency virus multiple infection and genome
RT divergence in a free-ranging population of African lions.";
RL J. Virol. 78:3777-3791(2004).
RN [2] {ECO:0000313|EMBL:AAS67736.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FIV-Ple {ECO:0000313|EMBL:AAS67736.1};
RX PubMed=18989457; DOI=10.1371/journal.pgen.1000251;
RA Antunes A., Troyer J.L., Roelke M.E., Pecon-Slattery J., Packer C.,
RA Winterbach C., Winterbach H., Hemson G., Frank L., Stander P., Siefert L.,
RA Driciru M., Funston P.J., Alexander K.A., Prager K.C., Mills G., Wildt D.,
RA Bush M., O'Brien S.J., Johnson W.E.;
RT "The evolutionary dynamics of the lion Panthera leo revealed by host and
RT viral population genomics.";
RL PLoS Genet. 4:E1000251-E1000251(2008).
CC -!- SIMILARITY: Belongs to the dUTPase family.
CC {ECO:0000256|ARBA:ARBA00006581}.
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DR EMBL; AY552619; AAS67736.1; -; Genomic_DNA.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0004170; F:dUTP diphosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006226; P:dUMP biosynthetic process; IEA:InterPro.
DR GO; GO:0046081; P:dUTP catabolic process; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR CDD; cd07557; trimeric_dUTPase; 1.
DR Gene3D; 1.10.10.200; -; 1.
DR Gene3D; 2.70.40.10; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR008181; dUTPase.
DR InterPro; IPR029054; dUTPase-like.
DR InterPro; IPR036157; dUTPase-like_sf.
DR InterPro; IPR033704; dUTPase_trimeric.
DR InterPro; IPR017856; Integrase-like_N.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR11241; DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE; 1.
DR PANTHER; PTHR11241:SF0; DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE; 1.
DR Pfam; PF00692; dUTPase; 1.
DR Pfam; PF02022; Integrase_Zn; 1.
DR SUPFAM; SSF51283; dUTPase-like; 1.
DR SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50876; ZF_INTEGRASE; 1.
PE 3: Inferred from homology;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750};
KW DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022750};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00450}.
FT DOMAIN 109..150
FT /note="Integrase-type"
FT /evidence="ECO:0000259|PROSITE:PS50876"
FT DOMAIN 152..216
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAS67736.1"
FT NON_TER 216
FT /evidence="ECO:0000313|EMBL:AAS67736.1"
SQ SEQUENCE 216 AA; 24080 MW; AE9AD021E58D0F4E CRC64;
PGEVRIIPTG VRLMLPKGHW GLVIGKSSIG KQGLDVLGGV IDEGYRGEIG VIMMNLNRKS
IILKEKQKIA QLILVPCRHE PLEQGEIKLD SARGEGGYGS TGAFASWIDK IEEAEINHER
FHSDPEYLRT EFGLPKQVAE EIKRKCPLCI VQGEQPMGKL RIGPGIWQAD CTHWEGKIIL
VAVNTESGYI WARIMPQETA DNTVKLFLQL ISEHHV
//
