ID Q6QWH9_ELECQ Unreviewed; 293 AA.
AC Q6QWH9;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Transcription factor Otx2 {ECO:0000313|EMBL:AAS49168.1};
DE Flags: Fragment;
OS Eleutherodactylus coqui (Puerto Rican coqui).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Eleutherodactylidae;
OC Eleutherodactylinae; Eleutherodactylus; Eleutherodactylus.
OX NCBI_TaxID=57060 {ECO:0000313|EMBL:AAS49168.1};
RN [1] {ECO:0000313|EMBL:AAS49168.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=9917359; DOI=10.1006/dbio.1998.9078;
RA Fang H., Elinson R.P.;
RT "Evolutionary alteration in anterior patterning: otx2 expression in the
RT direct developing frog Eleutherodactylus coqui.";
RL Dev. Biol. 205:233-239(1999).
RN [2] {ECO:0000313|EMBL:AAS49168.1}
RP NUCLEOTIDE SEQUENCE.
RA Burns M.M., Fang H., Elinson R.P.;
RT "Expression of neural plate patterning genes in Eleutherodactylus coqui.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000256|ARBA:ARBA00006503}.
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DR EMBL; AY523535; AAS49168.1; -; mRNA.
DR AlphaFoldDB; Q6QWH9; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003022; Otx2_TF.
DR InterPro; IPR003025; Otx_TF.
DR InterPro; IPR013851; Otx_TF_C.
DR PANTHER; PTHR45793; HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR45793:SF2; HOMEOBOX PROTEIN OTX2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03529; TF_Otx; 1.
DR PRINTS; PR01257; OTX2HOMEOBOX.
DR PRINTS; PR01255; OTXHOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}.
FT DOMAIN 40..100
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 42..101
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 97..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..140
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 293
FT /evidence="ECO:0000313|EMBL:AAS49168.1"
SQ SEQUENCE 293 AA; 32127 MW; 1A77B5ABA7607F02 CRC64;
MMSYLKQPPY AVNGLSLTTS GMDLLHPSVG YPAMFSATPR KQRRERTTFT RAQLDVLEAL
FAKTRYPDIF MREEVALKIN LPESRVQVWF KNRRAKCRQQ QQQQQNGGQN KVRPAKKKTS
PSREVSSESG TSGQFTPPCT TVPVITSSTA PVSIWSPASI SPLSDPLSTS SSCMQRSYPM
TYTQASGYSQ GYASSTSYFG GMDCGSYLTP MYHQLPGPGA ALSPMGTNAV ASHLNQSPAS
LSTQAYGASS LGFNSIADCL DYKDQTASWK LNFNADCLDY KDQTSSWKFQ VSS
//
