ID Q6R5W6_9ALPH Unreviewed; 352 AA.
AC Q6R5W6;
DT 13-OCT-2009, integrated into UniProtKB/TrEMBL.
DT 13-OCT-2009, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=UL23 {ECO:0000313|EMBL:ABF72258.1, ECO:0000313|EMBL:ABR13102.1};
DE SubName: Full=Thymidine kinase {ECO:0000313|EMBL:AAS01662.1};
GN Name=UL23 {ECO:0000313|EMBL:AAS01662.1};
GN ORFNames=MDV036 {ECO:0000313|EMBL:ABF72258.1};
OS Gallid alphaherpesvirus 2.
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Mardivirus;
OC Mardivirus gallidalpha2.
OX NCBI_TaxID=10390 {ECO:0000313|EMBL:AAS01662.1, ECO:0000313|Proteomes:UP000155729};
RN [1] {ECO:0000313|EMBL:AAS01662.1, ECO:0000313|Proteomes:UP000155729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Md11 {ECO:0000313|EMBL:AAS01662.1};
RX PubMed=16155725; DOI=10.1007/s00705-005-0633-7;
RA Niikura M., Dodgson J., Cheng H.;
RT "Direct evidence of host genome acquisition by the alphaherpesvirus Marek's
RT disease virus.";
RL Arch. Virol. 151:537-549(2006).
RN [2] {ECO:0000313|EMBL:ACF94841.1, ECO:0000313|Proteomes:UP000134498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CU-2 {ECO:0000313|EMBL:ACF94841.1};
RX PubMed=17557133; DOI=10.1007/s00705-007-0992-3;
RA Spatz S.J., Silva R.F.;
RT "Sequence determination of variable regions within the genomes of gallid
RT herpesvirus-2 pathotypes.";
RL Arch. Virol. 152:1665-1678(2007).
RN [3] {ECO:0000313|EMBL:ABF72258.1, ECO:0000313|Proteomes:UP000149312}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CVI988 {ECO:0000313|EMBL:ABF72258.1};
RX PubMed=17374751; DOI=10.1099/vir.0.82600-0;
RA Spatz S.J., Petherbridge L., Zhao Y., Nair V.;
RT "Comparative full-length sequence analysis of oncogenic and vaccine
RT (Rispens) strains of Marek's disease virus.";
RL J. Gen. Virol. 88:1080-1096(2007).
RN [4] {ECO:0000313|EMBL:ABR13102.1, ECO:0000313|Proteomes:UP000143489}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RB-1B {ECO:0000313|EMBL:ABR13102.1};
RX PubMed=17721813; DOI=10.1007/s11262-007-0157-1;
RA Spatz S.J., Zhao Y., Petherbridge L., Smith L.P., Baigent S.J., Nair V.;
RT "Comparative sequence analysis of a highly oncogenic but horizontal spread-
RT defective clone of Marek's disease virus.";
RL Virus Genes 35:753-766(2007).
RN [5] {ECO:0000313|EMBL:ACF94841.1, ECO:0000313|Proteomes:UP000134498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CU-2 {ECO:0000313|EMBL:ACF94841.1};
RX PubMed=18351449; DOI=10.1007/s11262-008-0213-5;
RA Spatz S.J., Rue C.A.;
RT "Sequence determination of a mildly virulent strain (CU-2) of Gallid
RT herpesvirus type 2 using 454 pyrosequencing.";
RL Virus Genes 36:479-489(2008).
RN [6] {ECO:0000313|EMBL:AEZ51678.1, ECO:0000313|Proteomes:UP000133397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMS {ECO:0000313|EMBL:AEZ51678.1};
RX PubMed=22476905; DOI=10.1007/s11262-012-0739-4;
RA Cheng Y., Cong F., Zhang Y.P., Li Z.J., Xu N.N., Hou G.Y., Liu C.J.;
RT "Genome sequence determination and analysis of a Chinese virulent strain,
RT LMS, of Gallid herpesvirus type 2.";
RL Virus Genes 45:56-62(2012).
RN [7] {ECO:0000313|Proteomes:UP000134084, ECO:0000313|Proteomes:UP000180864}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=648a {ECO:0000313|EMBL:AFM74594.1};
RX PubMed=22923089; DOI=10.1007/s11262-012-0792-z;
RA Spatz S.J., Volkening J.D., Gimeno I.M., Heidari M., Witter R.L.;
RT "Dynamic equilibrium of Marek's disease genomes during in vitro serial
RT passage.";
RL Virus Genes 45:526-536(2012).
RN [8] {ECO:0000313|EMBL:AUB50936.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATE2539 {ECO:0000313|EMBL:AUB50936.1}, EU-1
RC {ECO:0000313|EMBL:AUB51021.1}, and Polen5
RC {ECO:0000313|EMBL:AUB51191.1};
RX PubMed=29151863; DOI=10.1111/eva.12515;
RA Trimpert J., Groenke N., Jenckel M., He S., Kunec D., Szpara M.L.,
RA Spatz S.J., Osterrieder N., McMahon D.P.;
RT "A phylogenomic analysis of Marek's disease virus reveals independent paths
RT to virulence in Eurasia and North America.";
RL Evol. Appl. 10:1091-1101(2017).
RN [9] {ECO:0000313|EMBL:QOT14197.1}
RP NUCLEOTIDE SEQUENCE.
RA Conradie A.M., Bertzbach L.D., Trimpert J., Patria J.N., Murata S.,
RA Parcells M.S., Kaufer B.B.;
RT "Distinct polymorphisms in a single herpesvirus gene are capable of
RT enhancing virulence and mediate vaccinal resistance.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:QOT14011.1}
RP NUCLEOTIDE SEQUENCE.
RA Conradie A.M., Bertzbach L.D., Trimpert J.D., Patria J.N., Murata S.,
RA Parcells M.S., Kaufer B.B.;
RT "Distinct polymorphisms in a single herpesvirus gene are capable of
RT enhancing virulence and mediate vaccinal resistance.";
RL Submitted (JUL-2020) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:QOT14749.1}
RP NUCLEOTIDE SEQUENCE.
RA Conradie A.M., Kaufer B.;
RT "Marek's disease virus requires both copies of the inverted repeat regions
RT for efficient in vivo replication and pathogenesis.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
RN [12] {ECO:0000313|EMBL:QOT14881.1}
RP NUCLEOTIDE SEQUENCE.
RA Vychodil T., Conradie A.M., Trimpert J., Aswad A., Bertzbach L.D.,
RA Kaufer B.;
RT "Functional analysis of genomic repeat regions in Marek's disease virus
RT replication and pathogenesis.";
RL Submitted (SEP-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AY510475; AAS01662.1; -; Genomic_DNA.
DR EMBL; DQ530348; ABF72258.1; -; Genomic_DNA.
DR EMBL; EF523390; ABR13102.1; -; Genomic_DNA.
DR EMBL; EU499381; ACF94841.1; -; Genomic_DNA.
DR EMBL; JQ314003; AEZ51678.1; -; Genomic_DNA.
DR EMBL; JQ806361; AFM74594.1; -; Genomic_DNA.
DR EMBL; JQ806362; AFM74780.1; -; Genomic_DNA.
DR EMBL; JQ809691; AFM74970.1; -; Genomic_DNA.
DR EMBL; JQ809692; AFM75157.1; -; Genomic_DNA.
DR EMBL; JQ820250; AFM75338.1; -; Genomic_DNA.
DR EMBL; JQ836662; AFM75516.1; -; Genomic_DNA.
DR EMBL; MF431493; AUB50936.1; -; Genomic_DNA.
DR EMBL; MF431494; AUB51021.1; -; Genomic_DNA.
DR EMBL; MF431496; AUB51191.1; -; Genomic_DNA.
DR EMBL; MT797629; QOT14011.1; -; Genomic_DNA.
DR EMBL; MT797630; QOT14197.1; -; Genomic_DNA.
DR EMBL; MT797631; QOT14383.1; -; Genomic_DNA.
DR EMBL; MT813453; QOT14566.1; -; Genomic_DNA.
DR EMBL; MT872313; QOT14749.1; -; Genomic_DNA.
DR EMBL; MT955328; QOT14881.1; -; Genomic_DNA.
DR EMBL; MT994392; QOT15022.1; -; Genomic_DNA.
DR RefSeq; YP_001033951.1; NC_002229.3.
DR GeneID; 4811496; -.
DR KEGG; vg:4811496; -.
DR Proteomes; UP000133397; Genome.
DR Proteomes; UP000134084; Genome.
DR Proteomes; UP000134498; Genome.
DR Proteomes; UP000143489; Genome.
DR Proteomes; UP000149312; Genome.
DR Proteomes; UP000155729; Genome.
DR Proteomes; UP000180864; Genome.
DR Proteomes; UP000180974; Genome.
DR Proteomes; UP000181470; Genome.
DR Proteomes; UP000181580; Genome.
DR Proteomes; UP000181598; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006230; P:TMP biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_04029; HSV_KITH; 1.
DR InterPro; IPR001889; Herpes_TK.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00693; Herpes_TK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AAS01662.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000155729};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AAS01662.1}.
SQ SEQUENCE 352 AA; 40410 MW; 34A65B16BB0F67A2 CRC64;
MSEPQSWSVM ASQMTSAQLI RVYLDGSMGI GKTSMLNEIP THSLMGVPVL KVFEPMKYWR
YYFTDLVTTV NDTCDRRRRG EFSLFQSSMI VTALQSKFAD PYLVFHERLS SKCHRITGTR
GNPSLILILD RHPISATVCF PIARHLTGDC SLEMLISMII RLPQEPPGCN LVIVDLHDEK
EHVSRLSSRN RTGEKTDLLM LRALNAVYSC LVDTIMYANH ICPYSKDEWE SEWLDLPWFD
TSLATTFINE PRTDYRGSRV SLHHTLLAIF KRRELCAEDG SLSTTHAWIL WGLLMKLRNI
NVERFNITGL STTKCVESFM DTMSERLVTH MSWNDAFEIE ADVLAYNKEM AM
//
