ID Q6R7Z1_CAVPO Unreviewed; 802 AA.
AC Q6R7Z1;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 101.
DE RecName: Full=Oligophrenin-1 {ECO:0000256|ARBA:ARBA00034878};
OS Cavia porcellus (Guinea pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC Cavia.
OX NCBI_TaxID=10141 {ECO:0000313|EMBL:AAR90857.1};
RN [1] {ECO:0000313|EMBL:AAR90857.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Sciatic nerve {ECO:0000313|EMBL:AAR90857.1};
RX PubMed=12845702; DOI=10.1002/ar.a.10072;
RA Xiao J., Neylon C.B., Hunne B., Furness J.B.;
RT "Oligophrenin-1, a Rho GTPase-activating protein (RhoGAP) involved in X-
RT linked mental retardation, is expressed in the enteric nervous system.";
RL Anat. Rec. A Discov. Mol. Cell. Evol. Biol. 273A:671-676(2003).
RN [2] {ECO:0000313|EMBL:AAR90857.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Sciatic nerve {ECO:0000313|EMBL:AAR90857.1};
RA Xiao J., Neylon C.B., Nicholson G.A., Furness J.B.;
RT "Evidence that a major site of expression of the Rho-GTPase activating
RT protein, oligophrenin-1, is peripheral myelin.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Postsynapse
CC {ECO:0000256|ARBA:ARBA00034110}. Presynapse
CC {ECO:0000256|ARBA:ARBA00034106}.
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DR EMBL; AY508716; AAR90857.1; -; mRNA.
DR RefSeq; NP_001166568.1; NM_001173097.1.
DR AlphaFoldDB; Q6R7Z1; -.
DR GeneID; 100379222; -.
DR CTD; 4983; -.
DR OrthoDB; 5395569at2759; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0098794; C:postsynapse; IEA:UniProtKB-SubCell.
DR GO; GO:0098793; C:presynapse; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR CDD; cd07633; BAR_OPHN1; 1.
DR CDD; cd04374; RhoGAP_Graf; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR047267; OPHN1_BAR.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF2; OLIGOPHRENIN-1; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902}.
FT DOMAIN 265..368
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 372..564
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 569..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 604..770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 783..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..728
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..755
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 802 AA; 91329 MW; 704518D3621140A9 CRC64;
MGHPPLEFSD CYLDSPDFRE RLKCYEQELE RTNKFIKDVI KDGNALISAM RNYSSAVQKF
SQTLQSFQFD FIGDTLTDDE INIAESFKEF AELLNEVENE RMMMVHNASD LLIKPLENFR
KEQIGFTKER KKKFEKDGER FYSLLDRHLH LSSKKKESQL QEADLPVDKE RHNFFESSLD
YVYQIQEVQE PKKFNIVEPV LAFLHSLFIS NSLTVELTQD FLPYKQQLQL SLQNTRNHFS
STREEMEELK KRMKEAPQTC KLPGQPTIEG YLYTQEKWAL GISWVKYYCQ YEKETKTLTM
TPMEQKPGAK QGPLDLTLKY CVRRKTESID KRFCFDIETN ERPGTITLQA LSEANRRLWM
EAMDGKEPIY HSPITKQQEM ELNEGGFKFV RKCINIIETK GIKTEGLYPT VGSNIQVQKL
LNAFFEPKCP GNVDFHNSDW DIKTITSSLK FYLGNLSEPV MTYRLHKELV SAAKSDNLDY
RLGAIHSLVY KLPEKNREML ELLIRHLVNV CEHSKENLMT PSNMGVIFGP TLMRAQEDTV
AAMMNTKFQN IVVEILIEHF GKIYLGPPEE SAAPPVPPPR VTARRHKSIT ISKRLLRERT
VFYTSSMDES EDEIQHQTPN GTITSSIEPP KPPQHPKLPI QRSGETDPGR KSPSRPILDG
KLEPCPEVDV GKLVSGLQDG GTKITPKATN GPMPGSGPTK TPSFHIKRPA PRPLAHHKEG
DADSFSKVRP PGEKPTIIRP PVRPPDPPCR AATPQKPEPK PDIVAGNAGE ITSSVVASRT
RFFETASRKT GSSQGRLPGD ES
//
