ID Q6RKK4_GIBMO Unreviewed; 2319 AA.
AC Q6RKK4;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 115.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:AAR92218.1};
DE Flags: Fragment;
GN Name=PKS11 {ECO:0000313|EMBL:AAR92218.1};
OS Gibberella moniliformis (Maize ear and stalk rot fungus) (Fusarium
OS verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=117187 {ECO:0000313|EMBL:AAR92218.1};
RN [1] {ECO:0000313|EMBL:AAR92218.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 38932 {ECO:0000313|EMBL:AAR92218.1};
RX PubMed=14676319; DOI=10.1073/pnas.2532165100;
RA Kroken S., Glass N.L., Taylor J.W., Yoder O.C., Turgeon B.G.;
RT "Phylogenomic analysis of type I polyketide synthase genes in pathogenic
RT and saprobic ascomycetes.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:15670-15675(2003).
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DR EMBL; AY495601; AAR92218.1; -; Genomic_DNA.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF49; SYNTHASE, PUTATIVE (JCVI)-RELATED; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 29..451
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT NON_TER 2319
FT /evidence="ECO:0000313|EMBL:AAR92218.1"
SQ SEQUENCE 2319 AA; 251396 MW; 68FF92851BA59F5D CRC64;
MGVIESPSST TSGSAEEMAQ AITGHEDSVL PVAIVGMGMR LPGGIHTPDE LWGMLVEKRS
TRCEIPPTRF SVDGFHSPSS KPGSIAMRHG HFLDDKDDLH RLDTSFFSMG MTEVSDIDPQ
QRMLLEVAYE CMQSSGQTNW RGSNIGCYVG VWGEDWLDLH SKDLYDSGTY RVSGGHDFAI
SNRISYEYDL KGPSFTIKAG CSSSLIALHE AVRAIRAGDC DGAIVAGTNL VFSPTMSVAM
TEQGVLSPDA SCKTFDANAN GYARGEAINA IFLKPLNNAL REGDPIRALV RATSSNSDGK
TPGMSMPSSE SHEALIRRAY GEVFLDPKDT CFVEAHGTGT SVGDPLEATA IARVFGGSSD
NKLYIGSVKP NLGHSEGASG VSSVMKAVLA LENRTIPPNI NFSTPNPKIP FSEMNMAVPV
DAIPWPRDRP LRVSVNSFGI GGANAHCIIE TLEEYLGRSL PNESQVAPIR NGNGSVQADS
SSAVTSITAM KMEVRRKKRQ SAVEAAGLVS NLRLVADSTK IRPSKALYVL SAANPTSLRQ
SVMDYQKYLA SHKTDPVDVS YTLANRREHL SHRTYGVVTT ESTNDTPIVP DFSPLSKTNN
NSLPEINMIF TGQGAQWVGM GXXXXXXXXX XXXXIAYLGL VLSGLEHPPT WDLIRELSRP
AESSNVGRAE FSQPLVCAVQ VALVDLLRSW GITPAAVVGH SSGEMAAAYA AGAISSEEAI
TIAYYRGYVN QQYTRDGGMA AIGMGAQEVA PYLVEGVGVA CENSPQSVTL SGDKGVLEEV
CQKIKEQVPD CFVRQLKVNV AYHSHHMQDL GGLFENLLEG KVYSQSPTIP FFSSVTVQKI
TEPRSLDAAY WRQNLESPVR FTGAVKLLLE ARASTGSKQV FVEIGPHSAL SGPLRQIFKA
HGRGKEAYVS AMIRGEDCTE SLLKLAGELF CHGTSLQLSN VTADGDVVVD LPPYPWNHDR
EYWSESRVSK DWRFRKFPNH ELLGSRTLES SSLQPEWRNL IRLDGIPWLR DHQVLNDVVF
PCAGYLAMAV EAVRQVAGTS EIGGFTLKSV VVQSALVLTE SKPVEVLTSL RPVRLTNTLD
SAWWEFSIVA HNGTSWIKHC EGQVRPGQDA HQKTAVLPQS EPISQHYPRL VDNLYPELLR
IGLRYGPSFR GLDNVSCVPN GKKAAAMLRE TTVSESSYAI HPTTIDHCLQ LFFPASCDGA
FYRAEKLCVP TAIGRLYLAD GKSCEVESAR AEASAATNSG GSISGAATVV SKQNSTLLSL
EDGKFSPLEM DLAEDGNADL VGTARLEWKP NLDFADMCSL VRPSHASMND GPELDLVEQL
TLLAILEIHE RIDGAVTPGG HDHAHQHIPN FRGWIADQVT AAAEGRYRGV VADAREIASL
ERGARLSLMT NLRQQVLRTG AASAAVLIGR VVDHCEEIVK GELEGIELLQ AEDGLTNYYN
YVESRTDSID FFATAGHTRP TLRVLEIGAG TGGGAQVILE GLTNGKERLF STYAYTDISA
GFFVAAQERF KAYKGLDFKV LDITKDPSEQ GFESGSFDLI IAGNVIHATP TLNETLANVR
KLLAPEGYLF LQELSPKMRM VNLIMGILPG WWLGAAEGRV EEPYLDPSQW DTVLKETGFS
GVDSAIYDAP YPYHLNANII SRPAKESAPQ PRAIRGRLTL LHHADDTNSS SITQLREVLD
ARGLETDMVV FHEHEELKAG EQDVIISLLE LKKPFFSSIS AAQLESFQRI VAKLGSIEMI
WVTRPAQHGL SASDNPGFGL SLGLTRTLRS EQSLAITTLE IDQVNDESFK AVTNLAIKVL
DHREGGSTES TRGATTMDPD REYVVENGVV KVARYHPVSL SQELASRASK PEAVTLEIGR
MGLLQTLGWV PFPTSDPGYG EVTIEPRCAG LNFRVSLFLS IHSLIHLMLT MAVDKDVLLC
MGVVEATGVG IGLEGSGIIT KVGAGVGKFQ PGDPVFYLAD NCFSTQITIS AQRCAKIPSQ
LAFEDAATMP CVYATVIHSL LDVGGLRPGQ SILIHSACGG IGIAALNLCR NFQGLEIYTT
VGNEEKVQYL VDNFGLPRSR IFNSRDASFL YDVRAATQGR GVDLVLNSLS GDLLHASWQC
VAPYGKMLEI GKRDFIGKAR LEMDLFEANR SFIGIDLARF DSARCQKLLE RTAAMIQTGI
VQPIKPVKVF DASDAEGAFR YMQKGVHLGK IVVSIPPHSS TALPITPKPL QVKLNPEASY
LLVGGLGGLG RAAATWMVES GARYLIFFSR SAGLSVRDQA FFQELASQGC TAQAVRGDVL
NLADVELAMA SAPPGKPIRG VLQMSMVLRD KPFADMSLE
//