ID   Q6RZX1_HYPAT            Unreviewed;       327 AA.
AC   Q6RZX1;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   SubName: Full=Gld1 {ECO:0000313|EMBL:AAS49642.1};
DE            EC=1.1.1.72 {ECO:0000313|EMBL:AAS49642.1};
GN   Name=gld1 {ECO:0000313|EMBL:AAS49642.1};
OS   Hypocrea atroviridis (Trichoderma atroviride).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX   NCBI_TaxID=63577 {ECO:0000313|EMBL:AAS49642.1};
RN   [1] {ECO:0000313|EMBL:AAS49642.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=P1 {ECO:0000313|EMBL:AAS49642.1};
RX   PubMed=15531216; DOI=10.1016/j.fgb.2004.09.002;
RA   Seidl V., Seiboth B., Karaffa L., Kubicek C.P.;
RT   "The fungal STRE-element-binding protein Seb1 is involved but not essential
RT   for glycerol dehydrogenase (gld1) gene expression and glycerol accumulation
RT   in Trichoderma atroviride during osmotic stress.";
RL   Fungal Genet. Biol. 41:1132-1140(2004).
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DR   EMBL; AY484570; AAS49642.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6RZX1; -.
DR   OMA; ACATNQV; -.
DR   GO; GO:0047956; F:glycerol dehydrogenase [NADP+] activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR   PANTHER; PTHR11732:SF449; D-XYLOSE REDUCTASE [NAD(P)H]; 1.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PIRSF; PIRSF000097; AKR; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000313|EMBL:AAS49642.1}.
FT   DOMAIN          26..304
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        61
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         124
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            91
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   327 AA;  36658 MW;  BBFA3708A895B55A CRC64;
     MATDTSQKTL SSTTYTLNTG AKIPAVGFGT FANEGAKGET YAAVTKALDV GYRHLDCAWF
     YLNEDEVGDA IRDFLARRPD VTRKDLFICT KVWNHLHEPE DVKWSAKNSC ENLKVDYIDL
     FLVHWPIAAE KNADRTVKIG PDGKYVINKA LTENPEPTWR AMEELVDSGI VKAIGVSNWT
     IPGLKQLLEF ARIKPAVNQI EIHPFLPNTE LVEFCFQNDI LPEAYSPLGS QNQVPTTGER
     VRDNPTLNAV ADRRGSSLAQ VLLAWGLKRG YVVLPKSSTP SRIESNFIIP ELSEEDFAAI
     QKVAEGRHVR FVNMKDTFGY DVWPEDK
//