ID Q6RZZ5_TRYCR Unreviewed; 397 AA.
AC Q6RZZ5;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Glucose-6-phosphate isomerase {ECO:0000256|ARBA:ARBA00011952, ECO:0000256|RuleBase:RU000612};
DE EC=5.3.1.9 {ECO:0000256|ARBA:ARBA00011952, ECO:0000256|RuleBase:RU000612};
DE Flags: Fragment;
GN Name=Gpi {ECO:0000313|EMBL:AAR89395.1};
OS Trypanosoma cruzi.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=5693 {ECO:0000313|EMBL:AAR89395.1};
RN [1] {ECO:0000313|EMBL:AAR89395.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CANIIIcl1 {ECO:0000313|EMBL:AAR89395.1};
RX PubMed=16410006; DOI=10.1016/j.exppara.2005.11.014;
RA Broutin H., Tarrieu F., Tibayrenc M., Oury B., Barnabe C.;
RT "Phylogenetic analysis of the glucose-6-phosphate isomerase gene in
RT Trypanosoma cruzi.";
RL Exp. Parasitol. 113:1-7(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC EC=5.3.1.9; Evidence={ECO:0000256|ARBA:ARBA00029321,
CC ECO:0000256|RuleBase:RU000612};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 2/4.
CC {ECO:0000256|ARBA:ARBA00004926, ECO:0000256|RuleBase:RU000612}.
CC -!- SIMILARITY: Belongs to the GPI family. {ECO:0000256|ARBA:ARBA00006604,
CC ECO:0000256|RuleBase:RU000612}.
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DR EMBL; AY484474; AAR89395.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6RZZ5; -.
DR UniPathway; UPA00109; UER00181.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:InterPro.
DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05015; SIS_PGI_1; 1.
DR CDD; cd05016; SIS_PGI_2; 1.
DR HAMAP; MF_00473; G6P_isomerase; 1.
DR InterPro; IPR001672; G6P_Isomerase.
DR InterPro; IPR018189; Phosphoglucose_isomerase_CS.
DR InterPro; IPR046348; SIS_dom_sf.
DR InterPro; IPR035476; SIS_PGI_1.
DR InterPro; IPR035482; SIS_PGI_2.
DR PANTHER; PTHR11469; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR PANTHER; PTHR11469:SF1; GLUCOSE-6-PHOSPHATE ISOMERASE; 1.
DR Pfam; PF00342; PGI; 1.
DR PRINTS; PR00662; G6PISOMERASE.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS00765; P_GLUCOSE_ISOMERASE_1; 1.
DR PROSITE; PS51463; P_GLUCOSE_ISOMERASE_3; 1.
PE 3: Inferred from homology;
KW Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432,
KW ECO:0000256|RuleBase:RU000612};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152, ECO:0000256|RuleBase:RU000612};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU000612}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAR89395.1"
FT NON_TER 397
FT /evidence="ECO:0000313|EMBL:AAR89395.1"
SQ SEQUENCE 397 AA; 44099 MW; 496FC234E432327E CRC64;
FVDGNDVMHL VNKVLEQMKK LSEKVRRGEW KGQSGKPIRH VVNIGIGGSD LGPMMACEAL
KPFSDRRISM HFVSNIDGTH LSEVLKLVDL ESTLFIIASK TFTTQETITN ALSARSEFLK
FLSSRGIPEA GAVAKHFVAL STNAEKVKEF GIDEANMFQF WDWVGGRYSL WSAIGLSVMI
SIGYDNFVEF LTGAHIMDEH FINAPTENNL PIILALVGIW YNNFFGSETQ AILPYDQYLW
RLPAYLQQLD MESNGKGATK NGRMVSTHTG PIIFGEAGTN GQHAFYQLIH QGTKLIPCDF
IGAIQTQNHI GEHHRILMSN FFAQTEALMI GKTPEEVKRE LESAGGKSED EIQLLIPQKT
FTGGRPSNSL LVKALTPRAL GAIIAMYEHK VLVLLCI
//
