ID Q6T9C2_DANRE Unreviewed; 1387 AA.
AC Q6T9C2; Q6SPF1;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 152.
DE SubName: Full=RGS12TS {ECO:0000313|EMBL:AAR24263.1, ECO:0000313|EMBL:AAR24266.1};
DE SubName: Full=Regulator of G protein-signaling 12b {ECO:0000313|Ensembl:ENSDARP00000107011};
DE SubName: Full=Regulator of G-protein signaling 12 isoform X1 {ECO:0000313|RefSeq:XP_009291254.1, ECO:0000313|RefSeq:XP_021337063.1};
GN Name=rgs12b {ECO:0000313|Ensembl:ENSDARP00000107011,
GN ECO:0000313|RefSeq:XP_009291254.1, ECO:0000313|RefSeq:XP_021337063.1,
GN ECO:0000313|ZFIN:ZDB-GENE-031006-13};
GN Synonyms=cb958 {ECO:0000313|RefSeq:XP_009291254.1,
GN ECO:0000313|RefSeq:XP_021337063.1}, rgs12
GN {ECO:0000313|RefSeq:XP_009291254.1}, RGS12TS
GN {ECO:0000313|RefSeq:XP_009291254.1,
GN ECO:0000313|RefSeq:XP_021337063.1}, RGS12TS-I
GN {ECO:0000313|RefSeq:XP_009291254.1,
GN ECO:0000313|RefSeq:XP_021337063.1}, RGS12TS-L
GN {ECO:0000313|RefSeq:XP_009291254.1}, RGS12TS-S
GN {ECO:0000313|RefSeq:XP_009291254.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAR24263.1};
RN [1] {ECO:0000313|EMBL:AAR24263.1}
RP NUCLEOTIDE SEQUENCE.
RA Chatterjee T.K., Fisher R.A.;
RT "Zebra Fish RGS12TS exon 1.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAR24263.1}
RP NUCLEOTIDE SEQUENCE.
RA Chatterjee T.K., Fisher R.A.;
RT "Zebra Fish RGS12TS exon 2.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:AAR24263.1}
RP NUCLEOTIDE SEQUENCE.
RA Chatterjee T.K., Fisher R.A.;
RT "Zebra Fish RGS12TS exon 3.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AAR24263.1}
RP NUCLEOTIDE SEQUENCE.
RA Chatterjee T.K., Fisher R.A.;
RT "Zebra Fish RGS12TS exon 4.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:AAR24263.1}
RP NUCLEOTIDE SEQUENCE.
RA Chatterjee T.K., Fisher R.A.;
RT "Zebra Fish RGS12TS exon 6.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AAR24263.1}
RP NUCLEOTIDE SEQUENCE.
RA Chatterjee T.K., Fisher R.A.;
RT "Zebra Fish RGS12TS exon 8.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:AAR24263.1}
RP NUCLEOTIDE SEQUENCE.
RA Chatterjee T.K., Fisher R.A.;
RT "Zebra Fish RGS12TS exon 9.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [8] {ECO:0000313|EMBL:AAR24263.1}
RP NUCLEOTIDE SEQUENCE.
RA Chatterjee T.K., Fisher R.A.;
RT "Zebra Fish RGS12TS exon5.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:AAR24263.1}
RP NUCLEOTIDE SEQUENCE.
RA Chatterjee T.K., Fisher R.A.;
RT "Zebra fish RGS12TS intron 16 complete sequence.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|EMBL:AAR24266.1}
RP NUCLEOTIDE SEQUENCE.
RA Chatterjee T.K., Fisher R.A.;
RT "Zebra Fish RGS12TS-I mRNA.";
RL Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|Ensembl:ENSDARP00000107011}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000107011};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [12] {ECO:0000313|Ensembl:ENSDARP00000107011, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000107011,
RC ECO:0000313|Proteomes:UP000000437};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [13] {ECO:0000313|RefSeq:XP_009291254.1, ECO:0000313|RefSeq:XP_021337063.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_009291254.1,
RC ECO:0000313|RefSeq:XP_021337063.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AL954671; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AH013405; AAR24263.1; -; Genomic_DNA.
DR EMBL; AY427651; AAR24263.1; JOINED; Genomic_DNA.
DR EMBL; AY427652; AAR24263.1; JOINED; Genomic_DNA.
DR EMBL; AY427653; AAR24263.1; JOINED; Genomic_DNA.
DR EMBL; AY427654; AAR24263.1; JOINED; Genomic_DNA.
DR EMBL; AY427655; AAR24263.1; JOINED; Genomic_DNA.
DR EMBL; AY427656; AAR24263.1; JOINED; Genomic_DNA.
DR EMBL; AY427657; AAR24263.1; JOINED; Genomic_DNA.
DR EMBL; AY427658; AAR24263.1; JOINED; Genomic_DNA.
DR EMBL; AY427659; AAR24263.1; JOINED; Genomic_DNA.
DR EMBL; AY427660; AAR24263.1; JOINED; Genomic_DNA.
DR EMBL; AY427661; AAR24263.1; JOINED; Genomic_DNA.
DR EMBL; AY427662; AAR24263.1; JOINED; Genomic_DNA.
DR EMBL; AY427663; AAR24263.1; JOINED; Genomic_DNA.
DR EMBL; AY427664; AAR24263.1; JOINED; Genomic_DNA.
DR EMBL; AY427666; AAR24263.1; JOINED; Genomic_DNA.
DR EMBL; AY427670; AAR24266.1; -; mRNA.
DR RefSeq; XP_009291254.1; XM_009292979.2.
DR RefSeq; XP_021337063.1; XM_021481388.1.
DR Ensembl; ENSDART00000126853.4; ENSDARP00000107011.2; ENSDARG00000036774.9.
DR GeneID; 378970; -.
DR AGR; ZFIN:ZDB-GENE-031006-13; -.
DR CTD; 378970; -.
DR ZFIN; ZDB-GENE-031006-13; rgs12b.
DR OrthoDB; 22856at2759; -.
DR Proteomes; UP000000437; Chromosome 1.
DR Bgee; ENSDARG00000036774; Expressed in pharyngeal gill and 28 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd13162; PTB_RGS12; 1.
DR CDD; cd17136; RBD1_RGS12; 1.
DR CDD; cd17138; RBD2_RGS12; 1.
DR CDD; cd08742; RGS_RGS12; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR037880; RGS12_RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945:SF1; REGULATOR OF G-PROTEIN SIGNALING 12; 1.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF02188; GoLoco; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF16613; RGS12_us1; 1.
DR Pfam; PF16611; RGS12_us2; 1.
DR Pfam; PF16612; RGS12_usC; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00390; GoLoco; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00455; RBD; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50898; RBD; 2.
DR PROSITE; PS50132; RGS; 1.
PE 2: Evidence at transcript level;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 22..99
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 740..857
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 992..1062
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 1064..1134
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT REGION 424..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 463..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 631..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1140..1186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1232..1321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1345..1387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 424..442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..537
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..594
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..657
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 873..890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..915
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..984
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1149..1167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1253..1270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1284..1320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1387 AA; 152340 MW; 77E7465E218C73A6 CRC64;
MFRQSEQGRR RVNAQPSARI RGVEVARGRT GYGFTLSGQS PCVLNCILKG SPADYVGLRS
GDQILSVNDI NVSKASHEDV VKLIGRCTGV LHLVIAEGSH KNGHVDSCSS DEELEFHDHK
SHWLRPKMDS KTLGINRAER VVAEMQSGGI FNMIFENSSH SSSSSERAVA CASASKPRAV
SEPEFPYVSV NTQKSDPNLL TEEEMAKVLN DDSVFVDMFE PQDEFALLQT ADSAGILNVG
MIVGYLGSIE LASTSANLES DSLQAIRGCM RRLRAEQKVH SLVLLKVMHD CVQLCNDRGA
VLATYPAEKL AFSAVCPDDR RFFGLVTMQA TNDHRMYRHG EEEQGLRTSC HVFIVDPELC
HHKIHQGIAR RFGFDCTPDP DTGGCLEFPP TSQPLLQFVS VLYRDMGESI EGMRARAFLD
GDLDAQQNNS TSSNSDSGIG NFLPEEKNNR VLLVDLGANP SRHVPTGPWE NPMGSFCQGA
IGGLPPPPPP PPISHRNGFR HEQFVDHPQP HPHSHGDPPL LSGRHLNSSS RLDVSGLPSR
SHYSAHGKKA AGASGQRWLP VHVLRDWRQG HSSDQESYAE STDGWSSANC STLPPPMSKI
PADRYRAAGE IASQPHRLHA QKDEWAKKLF GEKNLREHSQ QSNNVRRAKD SEKKGGRFKG
ITMGFPQRSS GRRSFGRSKR LSMARSLDDL ESAAVSDGEL NSVDLKGCGS DNSLNSNASL
PSVQCHRRHT ERRVASWAVC FERLLQDPVG VRYFSEFLKK EFSEENILFW QACEYFSHVP
ETDKKQLSQR AREIYNSFLS SKATTPVNID SQAQLADDIL NAPRPDMFKE QQLQIFNLMK
FDSYTRFLKS YLYQECMLAE VEGRPLPDPY QVPSSPTSKH STGSDRSNLS TPKKVQDDKK
SKSGRSLNED SRDEHGDKKK SIFFSWSRNR SFGKGSKKRD LADYSFTGSN GRRESQGSLS
SGASLELATS GSGKNEGEVS RNSMSLSERA VRHCNINLPD GSCCSVPIRP GVSIREVLLG
LCEKLGINLA AVDLFLVGGE KPLVLDQDCM TLCSRDLRLE KRTLFRLDLV PINRSVGLKA
KPTKPVTEVL RPVVAKYGLN LGDLVATISG EKEPLDLGLP ISNLDGLRVV LEAGDHVSGK
DKQKLVSSKS HGPPLSTRSQ SATGEDKTAG KASAVKTRAQ VEKRKQKKLN IDEAEEFFEL
ISKAQSNRAD DQRGLLNKSD LVLPDFLRLD TEADGNNLSS TPISHKTRPR SKENGSALSA
SHQTQSLDSA GEGKAPRRAL MPPNSALRNT SSRIPPPFSS SLSPIPHSQM GGSSGITDWR
SDGGVQALEE EESGMDLTFV AEGDITSPNS SLLHQSPIPL PPSPERSHLL KEDTCQDSWA
RSGTSPV
//
