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Database: UniProt
Entry: Q6TNQ4_DANRE
LinkDB: Q6TNQ4_DANRE
Original site: Q6TNQ4_DANRE 
ID   Q6TNQ4_DANRE            Unreviewed;       160 AA.
AC   Q6TNQ4; Q6TNQ5;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 123.
DE   SubName: Full=Sorting nexin 12 {ECO:0000313|EMBL:AAQ91274.1, ECO:0000313|Ensembl:ENSDARP00000122910};
DE   SubName: Full=Sorting nexin 12, variation 2 {ECO:0000313|EMBL:AAQ91275.1};
DE   SubName: Full=Sorting nexin-12 isoform 2 {ECO:0000313|RefSeq:NP_001139365.1};
DE   SubName: Full=Sorting nexin-12 isoform X1 {ECO:0000313|RefSeq:XP_005161351.1};
GN   Name=SNX12-var1 {ECO:0000313|EMBL:AAQ91274.1};
GN   Synonyms=fc02c04 {ECO:0000313|RefSeq:NP_001139365.1,
GN   ECO:0000313|RefSeq:XP_005161351.1}, fc03c06
GN   {ECO:0000313|RefSeq:NP_001139365.1,
GN   ECO:0000313|RefSeq:XP_005161351.1}, fj97e07
GN   {ECO:0000313|RefSeq:NP_001139365.1,
GN   ECO:0000313|RefSeq:XP_005161351.1}, SNX12-var2
GN   {ECO:0000313|EMBL:AAQ91275.1}, wu:fc02c04
GN   {ECO:0000313|RefSeq:NP_001139365.1,
GN   ECO:0000313|RefSeq:XP_005161351.1}, wu:fc03c06
GN   {ECO:0000313|RefSeq:NP_001139365.1,
GN   ECO:0000313|RefSeq:XP_005161351.1}, wu:fj97e07
GN   {ECO:0000313|RefSeq:NP_001139365.1,
GN   ECO:0000313|RefSeq:XP_005161351.1}, zgc:158590
GN   {ECO:0000313|RefSeq:NP_001139365.1,
GN   ECO:0000313|RefSeq:XP_005161351.1}, zgc:55728
GN   {ECO:0000313|RefSeq:NP_001139365.1,
GN   ECO:0000313|RefSeq:XP_005161351.1}, zgc:77034
GN   {ECO:0000313|RefSeq:NP_001139365.1,
GN   ECO:0000313|RefSeq:XP_005161351.1};
GN   OrderedLocusNames=snx12 {ECO:0000313|Ensembl:ENSDARP00000122910,
GN   ECO:0000313|RefSeq:NP_001139365.1, ECO:0000313|RefSeq:XP_005161351.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-040426-787};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAQ91274.1};
RN   [1] {ECO:0000313|EMBL:AAQ91274.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.D., Sun X.J., Deng M., Zhang G.W., Zhou Y., Wu X.Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.L., Fan H.Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2] {ECO:0000313|RefSeq:NP_001139365.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001139365.1};
RX   PubMed=22213104;
RA   Xu L., Yin W., Xia J., Peng M., Li S., Lin S., Pei D., Shu X.;
RT   "An antiapoptotic role of sorting nexin 7 is required for liver development
RT   in zebrafish.";
RL   Hepatology 55:1985-1993(2012).
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000122910}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000122910};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSDARP00000122910, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000122910};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [5] {ECO:0000313|RefSeq:NP_001139365.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001139365.1};
RX   PubMed=26469318;
RA   Elkon R., Milon B., Morrison L., Shah M., Vijayakumar S., Racherla M.,
RA   Leitch C.C., Silipino L., Hadi S., Weiss-Gayet M., Barras E., Schmid C.D.,
RA   Ait-Lounis A., Barnes A., Song Y., Eisenman D.J., Eliyahu E.,
RA   Frolenkov G.I., Strome S.E., Durand B., Zaghloul N.A., Jones S.M.,
RA   Reith W., Hertzano R.;
RT   "RFX transcription factors are essential for hearing in mice.";
RL   Nat. Commun. 6:8549-8549(2015).
RN   [6] {ECO:0000313|RefSeq:NP_001139365.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001139365.1};
RX   PubMed=27189481;
RA   Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA   Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA   Bobe J.;
RT   "Gene evolution and gene expression after whole genome duplication in fish:
RT   the PhyloFish database.";
RL   BMC Genomics 17:368-368(2016).
RN   [7] {ECO:0000313|RefSeq:NP_001139365.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001139365.1};
RX   PubMed=28252024;
RA   Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA   Choudhary J.S., Emes R.D., Grant S.G.;
RT   "Evolution of complexity in the zebrafish synapse proteome.";
RL   Nat. Commun. 8:14613-14613(2017).
RN   [8] {ECO:0000313|RefSeq:NP_001139365.1, ECO:0000313|RefSeq:XP_005161351.1}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001139365.1,
RC   ECO:0000313|RefSeq:XP_005161351.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the sorting nexin family.
CC       {ECO:0000256|ARBA:ARBA00010883}.
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DR   EMBL; CR749164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY391462; AAQ91274.1; -; mRNA.
DR   EMBL; AY391463; AAQ91275.1; -; mRNA.
DR   RefSeq; NP_001139365.1; NM_001145893.1.
DR   RefSeq; XP_005161351.1; XM_005161294.4.
DR   Ensembl; ENSDART00000133478.3; ENSDARP00000122910.1; ENSDARG00000019060.11.
DR   GeneID; 394098; -.
DR   CTD; 29934; -.
DR   ZFIN; ZDB-GENE-040426-787; snx12.
DR   OrthoDB; 5475877at2759; -.
DR   Proteomes; UP000000437; Chromosome 21.
DR   Bgee; ENSDARG00000019060; Expressed in swim bladder and 25 other cell types or tissues.
DR   GO; GO:0031901; C:early endosome membrane; IBA:GO_Central.
DR   GO; GO:0030904; C:retromer complex; IBA:GO_Central.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IBA:GO_Central.
DR   GO; GO:0032456; P:endocytic recycling; IBA:GO_Central.
DR   GO; GO:0034499; P:late endosome to Golgi transport; IBA:GO_Central.
DR   CDD; cd07294; PX_SNX12; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   PANTHER; PTHR45963; RE52028P; 1.
DR   PANTHER; PTHR45963:SF3; SORTING NEXIN-12; 1.
DR   Pfam; PF00787; PX; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS50195; PX; 1.
PE   1: Evidence at protein level;
KW   Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:Q6TNQ4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   DOMAIN          28..152
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   160 AA;  18657 MW;  FBFC974DBD0EF51F CRC64;
     MSEATVADTR RLNSKPQDLT DAYGPPSNFL EIDVYDPQTI GVGRNRFTTY EVRMRTNLPI
     FKLKESVVRR RYSDFEWLKN ELERDSKIVV PPLPGKALKR QLPFRGDEGI FEESFIEERR
     AGLEQFINRI AGHPLAQNER CLHMFLQDES IDRNYIPGKV
//
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