ID Q6TSN8_BACTU Unreviewed; 134 AA.
AC Q6TSN8;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 91.
DE RecName: Full=orotate phosphoribosyltransferase {ECO:0000256|ARBA:ARBA00011971};
DE EC=2.4.2.10 {ECO:0000256|ARBA:ARBA00011971};
DE Flags: Fragment;
GN Name=pyrE {ECO:0000313|EMBL:AAQ90822.1};
OS Bacillus thuringiensis.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1428 {ECO:0000313|EMBL:AAQ90822.1};
RN [1] {ECO:0000313|EMBL:AAQ90822.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AH 1031 {ECO:0000313|EMBL:AAQ90826.1}, AH 251
RC {ECO:0000313|EMBL:AAQ90835.1}, and AH 840
RC {ECO:0000313|EMBL:AAQ90822.1};
RX PubMed=14711642; DOI=10.1128/AEM.70.1.191-201.2004;
RA Helgason E., Tourasse N.J., Meisal R., Caugant D.A., Kolsto A.B.;
RT "Multilocus sequence typing scheme for bacteria of the Bacillus cereus
RT group.";
RL Appl. Environ. Microbiol. 70:191-201(2004).
RN [2] {ECO:0000313|EMBL:ABU46089.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=BGSC4AH1 {ECO:0000313|EMBL:ABU46089.1}, BGSC4AJ1
RC {ECO:0000313|EMBL:ABU46090.1}, BGSC4AS1 {ECO:0000313|EMBL:ABU46091.1},
RC BGSC4AU1 {ECO:0000313|EMBL:ABU46092.1}, BGSC4AW1
RC {ECO:0000313|EMBL:ABU46093.1}, BGSC4AY1 {ECO:0000313|EMBL:ABU46094.1},
RC and BGSC4Y1 {ECO:0000313|EMBL:ABU46095.1};
RX PubMed=17997177; DOI=10.1016/j.mimet.2007.10.001;
RA Olsen J.S., Skogan G., Fykse E.M., Rawlinson E.L., Tomaso H., Granum P.E.,
RA Blatny J.M.;
RT "Genetic distribution of 295 Bacillus cereus group members based on adk-
RT screening in combination with MLST (Multilocus Sequence Typing) used for
RT validating a primer targeting a chromosomal locus in B. anthracis.";
RL J. Microbiol. Methods 71:265-274(2007).
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC UMP from orotate: step 1/2. {ECO:0000256|ARBA:ARBA00004889}.
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DR EMBL; AY388203; AAQ90822.1; -; Genomic_DNA.
DR EMBL; AY388207; AAQ90826.1; -; Genomic_DNA.
DR EMBL; AY388216; AAQ90835.1; -; Genomic_DNA.
DR EMBL; EF554035; ABU46089.1; -; Genomic_DNA.
DR EMBL; EF554036; ABU46090.1; -; Genomic_DNA.
DR EMBL; EF554037; ABU46091.1; -; Genomic_DNA.
DR EMBL; EF554038; ABU46092.1; -; Genomic_DNA.
DR EMBL; EF554039; ABU46093.1; -; Genomic_DNA.
DR EMBL; EF554040; ABU46094.1; -; Genomic_DNA.
DR EMBL; EF554041; ABU46095.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6TSN8; -.
DR UniPathway; UPA00070; UER00119.
DR GO; GO:0004588; F:orotate phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0044205; P:'de novo' UMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR HAMAP; MF_01208; PyrE; 1.
DR InterPro; IPR023031; OPRT.
DR InterPro; IPR004467; Or_phspho_trans_dom.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR NCBIfam; TIGR00336; pyrE; 1.
DR PANTHER; PTHR19278; OROTATE PHOSPHORIBOSYLTRANSFERASE; 1.
DR PANTHER; PTHR19278:SF9; URIDINE 5'-MONOPHOSPHATE SYNTHASE; 1.
DR Pfam; PF00156; Pribosyltran; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000313|EMBL:AAQ90822.1};
KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975};
KW Transferase {ECO:0000313|EMBL:AAQ90822.1}.
FT DOMAIN 36..133
FT /note="Phosphoribosyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00156"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAQ90822.1"
FT NON_TER 134
FT /evidence="ECO:0000313|EMBL:AAQ90822.1"
SQ SEQUENCE 134 AA; 14273 MW; 8F93ED898E452DF4 CRC64;
GAVFLQPNDP FTWSSGMKSP IYCDNRLTLS YPKVRQAIAA GLEELIKEHF PTVEVIAGTA
TAGIAHAAWV SDRMDLPMCY VRSKAKGHGK GNQIEGKAEK GQKVVVVEDL ISTGGSAITC
VEALREAGCE VLGI
//
