ID Q6V6J6_DROSI Unreviewed; 372 AA.
AC Q6V6J6;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE SubName: Full=Pelle {ECO:0000313|EMBL:AAQ64745.1};
DE Flags: Fragment;
GN Name=pll {ECO:0000313|FlyBase:FBgn0067491};
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000313|EMBL:AAQ64745.1};
RN [1] {ECO:0000313|EMBL:AAQ64745.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Sim1 {ECO:0000313|EMBL:AAQ64744.1}, Sim2
RC {ECO:0000313|EMBL:AAQ64745.1}, Sim3 {ECO:0000313|EMBL:AAQ64746.1},
RC Sim4 {ECO:0000313|EMBL:AAQ64747.1}, Sim5
RC {ECO:0000313|EMBL:AAQ64748.1}, Sim6 {ECO:0000313|EMBL:AAQ64749.1},
RC Sim7 {ECO:0000313|EMBL:AAQ64750.1}, and Sim8
RC {ECO:0000313|EMBL:AAQ64751.1};
RX PubMed=12930753;
RA Schlenke T.A., Begun D.J.;
RT "Natural selection drives Drosophila immune system evolution.";
RL Genetics 164:1471-1480(2003).
CC -!- SIMILARITY: Belongs to the protein kinase superfamily.
CC {ECO:0000256|RuleBase:RU000304}.
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DR EMBL; AY349793; AAQ64744.1; -; Genomic_DNA.
DR EMBL; AY349794; AAQ64745.1; -; Genomic_DNA.
DR EMBL; AY349795; AAQ64746.1; -; Genomic_DNA.
DR EMBL; AY349796; AAQ64747.1; -; Genomic_DNA.
DR EMBL; AY349797; AAQ64748.1; -; Genomic_DNA.
DR EMBL; AY349798; AAQ64749.1; -; Genomic_DNA.
DR EMBL; AY349799; AAQ64750.1; -; Genomic_DNA.
DR EMBL; AY349800; AAQ64751.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6V6J6; -.
DR EnsemblMetazoa; FBtr0363567; FBpp0327090; FBgn0269378.
DR FlyBase; FBgn0067491; Dsim\pll.
DR Bgee; FBgn0269378; Expressed in embryo and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblMetazoa.
DR GO; GO:0005886; C:plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019904; F:protein domain specific binding; IEA:EnsemblMetazoa.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0061760; P:antifungal innate immune response; IEA:EnsemblMetazoa.
DR GO; GO:0048262; P:determination of dorsal/ventral asymmetry; IEA:EnsemblMetazoa.
DR GO; GO:0007526; P:larval somatic muscle development; IEA:EnsemblMetazoa.
DR GO; GO:0002804; P:positive regulation of antifungal peptide production; IEA:EnsemblMetazoa.
DR GO; GO:0035332; P:positive regulation of hippo signaling; IEA:EnsemblMetazoa.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IEA:EnsemblMetazoa.
DR GO; GO:2000060; P:positive regulation of ubiquitin-dependent protein catabolic process; IEA:EnsemblMetazoa.
DR GO; GO:0046777; P:protein autophosphorylation; IEA:EnsemblMetazoa.
DR GO; GO:0008063; P:Toll signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0007352; P:zygotic specification of dorsal/ventral axis; IEA:EnsemblMetazoa.
DR CDD; cd14066; STKc_IRAK; 1.
DR Gene3D; 1.20.5.530; Single helix bin; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR27001:SF930; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; 1.
DR PANTHER; PTHR27001; OS01G0253100 PROTEIN; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022527, ECO:0000256|RuleBase:RU000304};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527,
KW ECO:0000256|RuleBase:RU000304};
KW Transferase {ECO:0000256|ARBA:ARBA00022527, ECO:0000256|RuleBase:RU000304}.
FT DOMAIN 1..47
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT DOMAIN 139..372
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 69..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 166
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAQ64745.1"
FT NON_TER 372
FT /evidence="ECO:0000313|EMBL:AAQ64745.1"
SQ SEQUENCE 372 AA; 41852 MW; B838E7867D217BBD CRC64;
QKQRGRSASN EFLNIWGGQY NHTVQTLFAL FKKLKLHNAM RLIKDYVSED LHKYIPRSVP
TISELRAAPD SSAKVDNGPP FPSSSGVSNS NNNRTSTTAT EEIPSLESLG NIHISTVQRA
AESLLEIDYA ELENATDGWS PDNRLGQGGF GDVYRGKWKQ LDVAIKVMNY RSPNIDQKMV
ELQQSYNELK YLNSIRHDNI LALYGYSIKG GKPCLVYQLM KGGSLEARLR AHKAQNPLPA
LTWQQRFSIS LGTARGIYFL HTARGTPLIH GDIKPANILL DQCLLPKIGD FGLVREGPKS
LDAVVEVNKV FGTKIYLPPE FRNFRQLSTG VDVYSFGIVL LEVFTGRQVT DRVPENETKK
NLLDYVKQQW RQ
//
