UniProt: Q6VRL4

Database: UniProt
Entry: Q6VRL4_HELPX

LinkDB:  Q6VRL4_HELPX 
Original site:  Q6VRL4_HELPX

All links

Ontology (1)   
   GO (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (23)   
   EMBL (23)   
Protein domain (3)   
   InterPro (2)   
   Pfam (1)   
Literature (4)   
   PubMed (4)   
All databases (32)   

Download RDF

ID   Q6VRL4_HELPX            Unreviewed;       252 AA.
AC   Q6VRL4;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=Cag pathogenicity island protein {ECO:0000313|EMBL:KOS35811.1};
DE   SubName: Full=Cag pathogenicity island type IV secretion system protein CagV {ECO:0000313|EMBL:MUU35050.1};
DE   SubName: Full=Cag10 {ECO:0000313|EMBL:AAR03923.1};
DE   SubName: Full=VirB8 family protein {ECO:0000313|EMBL:KAA6494304.1};
DE   SubName: Full=VirB8 protein {ECO:0000313|EMBL:BBI24258.1};
GN   Name=cag10 {ECO:0000313|EMBL:AAR03923.1};
GN   Synonyms=cagV {ECO:0000313|EMBL:MUU35050.1};
GN   ORFNames=AM498_01645 {ECO:0000313|EMBL:KOS35811.1}, BB459_01820
GN   {ECO:0000313|EMBL:PDX24050.1}, C2R74_00210
GN   {ECO:0000313|EMBL:PUD49484.1}, C2S42_07900
GN   {ECO:0000313|EMBL:PUB91990.1}, CV726_04920
GN   {ECO:0000313|EMBL:QDY57949.1}, DD754_02585
GN   {ECO:0000313|EMBL:RKV37296.1}, DD783_02735
GN   {ECO:0000313|EMBL:RKV26664.1}, EC503_05965
GN   {ECO:0000313|EMBL:RVY89996.1}, EC520_04905
GN   {ECO:0000313|EMBL:RVZ01530.1}, EC541_03105
GN   {ECO:0000313|EMBL:RVZ32035.1}, EC582_05330
GN   {ECO:0000313|EMBL:RVZ65709.1}, ECB88_07690
GN   {ECO:0000313|EMBL:RVY09865.1}, ECC09_04980
GN   {ECO:0000313|EMBL:RVY24200.1}, ECC12_07475
GN   {ECO:0000313|EMBL:RVY27310.1}, ECC24_04750
GN   {ECO:0000313|EMBL:RVY49796.1}, EPC76_07840
GN   {ECO:0000313|EMBL:KAA6494304.1}, EPC81_06135
GN   {ECO:0000313|EMBL:KAA6509828.1}, F7213_06320
GN   {ECO:0000313|EMBL:MUU51638.1}, F7219_04290
GN   {ECO:0000313|EMBL:MUU35050.1}, F7220_06105
GN   {ECO:0000313|EMBL:MUU96828.1}, HP0530 {ECO:0000313|EMBL:AAR03923.1},
GN   HPPMSS1_c00715 {ECO:0000313|EMBL:BBI24258.1};
OS   Helicobacter pylori (Campylobacter pylori).
OC   Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=210 {ECO:0000313|EMBL:AAR03923.1};
RN   [1] {ECO:0000313|EMBL:AAR03923.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Ca52 {ECO:0000313|EMBL:AAR03865.1}, and Du52:2
RC   {ECO:0000313|EMBL:AAR03923.1};
RX   PubMed=15019987; DOI=10.1016/j.gene.2003.11.029;
RA   Blomstergren A., Lundin A., Nilsson C., Engstrand L., Lundeberg J.;
RT   "Comparative analysis of the complete cag pathogenicity island sequence in
RT   four Helicobacter pylori isolates.";
RL   Gene 328:85-93(2004).
RN   [2] {ECO:0000313|EMBL:KOS35811.1, ECO:0000313|Proteomes:UP000037767}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=22 {ECO:0000313|EMBL:KOS35811.1,
RC   ECO:0000313|Proteomes:UP000037767};
RA   Kumar N., Albert M.J., Al-Akbal H.M., Ahmed N.;
RT   "Comparative genomics of Helicobacter pylori strains.";
RL   Submitted (AUG-2015) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:BBI24258.1, ECO:0000313|Proteomes:UP000289502}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PMSS1 {ECO:0000313|EMBL:BBI24258.1,
RC   ECO:0000313|Proteomes:UP000289502};
RA   Mimuro H., Ogura Y., Katsura K., Hayashi T.;
RT   "Whole genome shotgun sequence of Helicobacter pylori strain PMSS1.";
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:PDX24050.1, ECO:0000313|Proteomes:UP000220100}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3004 {ECO:0000313|EMBL:PDX24050.1,
RC   ECO:0000313|Proteomes:UP000220100};
RX   PubMed=28912838; DOI=.1186/s13099-017-0201-1;
RA   Gutierrez-Escobar A.J., Trujillo E., Acevedo O., Bravo M.M.;
RT   "Phylogenomics of Colombian Helicobacter pylori isolates.";
RL   Gut Pathog. 9:52-52(2017).
RN   [5] {ECO:0000313|Proteomes:UP000244365, ECO:0000313|Proteomes:UP000244566}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=55:1 {ECO:0000313|EMBL:PUB91990.1,
RC   ECO:0000313|Proteomes:UP000244566}, and GC52-HL
RC   {ECO:0000313|EMBL:PUD49484.1, ECO:0000313|Proteomes:UP000244365};
RA   Berthenet E., Yahara K., Thorell K., Pascoe B., Meric G., Mikhail J.M.,
RA   Engstrand L., Enroth H., Burette A., Megraud F., Atherton J., Smith S.,
RA   Wilkinson T.S., Hitchings M.D., Falush D., Sheppard S.K.;
RT   "Helicobacter pylori genome-wide association study shows promise for
RT   predicting gastric cancer risk.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|Proteomes:UP000270257, ECO:0000313|Proteomes:UP000278299}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B572A {ECO:0000313|EMBL:RKV37296.1,
RC   ECO:0000313|Proteomes:UP000270257}, and ECF139-B065
RC   {ECO:0000313|EMBL:RKV26664.1, ECO:0000313|Proteomes:UP000278299};
RA   Palau M., Minana-Galbis D.;
RT   "Complete genome sequences of Helicobacter pylori.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|Proteomes:UP000288702, ECO:0000313|Proteomes:UP000288766}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ZH01 {ECO:0000313|EMBL:RVY09865.1,
RC   ECO:0000313|Proteomes:UP000289011}, ZH119
RC   {ECO:0000313|EMBL:RVZ65709.1, ECO:0000313|Proteomes:UP000288865}, ZH12
RC   {ECO:0000313|EMBL:RVY24200.1, ECO:0000313|Proteomes:UP000288984}, ZH15
RC   {ECO:0000313|EMBL:RVY27310.1, ECO:0000313|Proteomes:UP000288766}, ZH26
RC   {ECO:0000313|EMBL:RVY49796.1, ECO:0000313|Proteomes:UP000288702}, ZH57
RC   {ECO:0000313|EMBL:RVY89996.1, ECO:0000313|Proteomes:UP000288916}, ZH72
RC   {ECO:0000313|EMBL:RVZ01530.1, ECO:0000313|Proteomes:UP000288816}, and
RC   ZH91 {ECO:0000313|EMBL:RVZ32035.1, ECO:0000313|Proteomes:UP000288778};
RA   Wagner K.;
RT   "Genetic determinants and prediction of antibiotic resistance phenotypes in
RT   Helicobacter pylori.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:QDY57949.1, ECO:0000313|Proteomes:UP000319625}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B130A {ECO:0000313|EMBL:QDY57949.1,
RC   ECO:0000313|Proteomes:UP000319625};
RX   PubMed=31371778; DOI=.1038/s41598-019-47240-2;
RA   Su H., Tissera K., Jang S., Choi Y.H., Kim A., Cho Y.J., Li M.,
RA   Gunawardhana N., Merrell D.S., Ge L., Cha J.H.;
RT   "Evolutionary mechanism leading to the multi-cagA genotype in Helicobacter
RT   pylori.";
RL   Sci. Rep. 9:11203-11203(2019).
RN   [9] {ECO:0000313|Proteomes:UP000323960, ECO:0000313|Proteomes:UP000324579}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PIMM-FM-UNAM-14CaC1 {ECO:0000313|EMBL:KAA6494304.1,
RC   ECO:0000313|Proteomes:UP000323960}, and PIMM-FM-UNAM-30CaCe
RC   {ECO:0000313|EMBL:KAA6509828.1, ECO:0000313|Proteomes:UP000324579};
RA   Mucito-Varela E., Castillo-Rojas G., Lopez-Vidal Y.;
RT   "Comparative genomics of H. pylori isolated from gastric cancer in
RT   Mexico.";
RL   Submitted (JAN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|Proteomes:UP000431996, ECO:0000313|Proteomes:UP000437749}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHP08 {ECO:0000313|EMBL:MUU96828.1,
RC   ECO:0000313|Proteomes:UP000431996}, MHP09C
RC   {ECO:0000313|EMBL:MUU51638.1, ECO:0000313|Proteomes:UP000474868}, and
RC   MHP11 {ECO:0000313|EMBL:MUU35050.1,
RC   ECO:0000313|Proteomes:UP000437749};
RX   PubMed=31801839;
RA   Saranathan R., Levi M.H., Wattam A.R., Malek A., Asare E., Behin D.S.,
RA   Pan D.H., Jacobs W.R., Szymczak W.A.;
RT   "Helicobacter pylori infections in the Bronx, New York: Surveying
RT   Antibiotic Susceptibility and Strain Lineage by Whole-genome Sequencing.";
RL   J. Clin. Microbiol. 0:0-0(2020).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AH013325; AAR03865.1; -; Genomic_DNA.
DR   EMBL; AH013327; AAR03923.1; -; Genomic_DNA.
DR   EMBL; AP017633; BBI24258.1; -; Genomic_DNA.
DR   EMBL; SBAI01000020; KAA6494304.1; -; Genomic_DNA.
DR   EMBL; SAZZ01000010; KAA6509828.1; -; Genomic_DNA.
DR   EMBL; LIXF01000005; KOS35811.1; -; Genomic_DNA.
DR   EMBL; WADZ01000009; MUU35050.1; -; Genomic_DNA.
DR   EMBL; WAEC01000013; MUU51638.1; -; Genomic_DNA.
DR   EMBL; WAED01000014; MUU96828.1; -; Genomic_DNA.
DR   EMBL; MBIX01000024; PDX24050.1; -; Genomic_DNA.
DR   EMBL; QBPK01000061; PUB91990.1; -; Genomic_DNA.
DR   EMBL; QBQR01000002; PUD49484.1; -; Genomic_DNA.
DR   EMBL; CP024950; QDY57949.1; -; Genomic_DNA.
DR   EMBL; QEGL01000010; RKV26664.1; -; Genomic_DNA.
DR   EMBL; QEGS01000008; RKV37296.1; -; Genomic_DNA.
DR   EMBL; RJDZ01000019; RVY09865.1; -; Genomic_DNA.
DR   EMBL; RJEL01000007; RVY24200.1; -; Genomic_DNA.
DR   EMBL; RJEO01000024; RVY27310.1; -; Genomic_DNA.
DR   EMBL; RJEZ01000012; RVY49796.1; -; Genomic_DNA.
DR   EMBL; RJGD01000013; RVY89996.1; -; Genomic_DNA.
DR   EMBL; RJGQ01000007; RVZ01530.1; -; Genomic_DNA.
DR   EMBL; RJHF01000007; RVZ32035.1; -; Genomic_DNA.
DR   EMBL; RJIE01000005; RVZ65709.1; -; Genomic_DNA.
DR   RefSeq; WP_000900784.1; NZ_WAED01000014.1.
DR   PATRIC; fig|210.1965.peg.350; -.
DR   OMA; ENVANEY; -.
DR   Proteomes; UP000037767; Unassembled WGS sequence.
DR   Proteomes; UP000220100; Unassembled WGS sequence.
DR   Proteomes; UP000244365; Unassembled WGS sequence.
DR   Proteomes; UP000244566; Unassembled WGS sequence.
DR   Proteomes; UP000270257; Unassembled WGS sequence.
DR   Proteomes; UP000278299; Unassembled WGS sequence.
DR   Proteomes; UP000288702; Unassembled WGS sequence.
DR   Proteomes; UP000288766; Unassembled WGS sequence.
DR   Proteomes; UP000288778; Unassembled WGS sequence.
DR   Proteomes; UP000288816; Unassembled WGS sequence.
DR   Proteomes; UP000288865; Unassembled WGS sequence.
DR   Proteomes; UP000288916; Unassembled WGS sequence.
DR   Proteomes; UP000288984; Unassembled WGS sequence.
DR   Proteomes; UP000289011; Unassembled WGS sequence.
DR   Proteomes; UP000289502; Chromosome.
DR   Proteomes; UP000319625; Chromosome.
DR   Proteomes; UP000323960; Unassembled WGS sequence.
DR   Proteomes; UP000324579; Unassembled WGS sequence.
DR   Proteomes; UP000431996; Unassembled WGS sequence.
DR   Proteomes; UP000437749; Unassembled WGS sequence.
DR   Proteomes; UP000474868; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.450.230; VirB8 protein; 1.
DR   InterPro; IPR032710; NTF2-like_dom_sf.
DR   InterPro; IPR007430; VirB8.
DR   Pfam; PF04335; VirB8; 1.
DR   SUPFAM; SSF54427; NTF2-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        38..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          24..225
FT                   /note="Bacterial virulence protein VirB8"
FT                   /evidence="ECO:0000259|Pfam:PF04335"
SQ   SEQUENCE   252 AA;  29067 MW;  96E175A9C1A95D4D CRC64;
     MLGKKNEEVL IDENLVGGVI ALDRLAKLNK ANRTFKRAFY LSMALNVAAV TSIVMMMPLK
     KTDIFVYGID RYTGEFKIVK RSDARQIVNS EAVVDSATSK FVSLLFGYSK NSLRDRKDQL
     MQYCDVSFQT QAMRMFNENI RQFVDKVRAE AIISSNIQRE KVKNSPLTRL TFFITIKITP
     DTMENYEYIT KKQVTIYYDF ARGNSSQENL IINPFGFKVF DIQITDLQNE QTVSEILRKI
     KEVESKNKAL NK
//

DBGET integrated database retrieval system