ID Q6WP05_9EUKA Unreviewed; 384 AA.
AC Q6WP05;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Tubulin alpha chain {ECO:0000256|RuleBase:RU000352};
DE Flags: Fragment;
OS Hypotrichomonas acosta.
OC Eukaryota; Metamonada; Parabasalia; Hypotrichomonadida;
OC Hypotrichomonadidae; Hypotrichomonas.
OX NCBI_TaxID=5735 {ECO:0000313|EMBL:AAQ19197.1};
RN [1] {ECO:0000313|EMBL:AAQ19197.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 30069 {ECO:0000313|EMBL:AAQ19197.1};
RA Gerbod D., Sanders E., Moriya S., Noel C., Takasu H., Fast N.M.,
RA Delgado-Viscogliosi P., Ohkuma M., Kudo T., Capron M., Palmer J.D.,
RA Keeling P.J., Viscogliosi E.;
RT "Molecular phylogenies of Parabasalia inferred from various protein coding
RT gene sequences and comparison with small subunit rRNA-based trees.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Tubulin is the major constituent of microtubules, a cylinder
CC consisting of laterally associated linear protofilaments composed of
CC alpha- and beta-tubulin heterodimers. Microtubules grow by the addition
CC of GTP-tubulin dimers to the microtubule end, where a stabilizing cap
CC forms. Below the cap, tubulin dimers are in GDP-bound state, owing to
CC GTPase activity of alpha-tubulin. {ECO:0000256|RuleBase:RU000352}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC hollow water-filled tube with an outer diameter of 25 nm and an inner
CC diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC form protofilaments running lengthwise along the microtubule wall with
CC the beta-tubulin subunit facing the microtubule plus end conferring a
CC structural polarity. Microtubules usually have 13 protofilaments but
CC different protofilament numbers can be found in some organisms and
CC specialized cells. {ECO:0000256|RuleBase:RU000352}.
CC -!- SIMILARITY: Belongs to the tubulin family.
CC {ECO:0000256|ARBA:ARBA00009636, ECO:0000256|RuleBase:RU000352}.
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DR EMBL; AY277776; AAQ19197.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6WP05; -.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR CDD; cd02186; alpha_tubulin; 1.
DR Gene3D; 1.10.287.600; Helix hairpin bin; 1.
DR Gene3D; 3.30.1330.20; Tubulin/FtsZ, C-terminal domain; 1.
DR Gene3D; 3.40.50.1440; Tubulin/FtsZ, GTPase domain; 1.
DR InterPro; IPR002452; Alpha_tubulin.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; TUBULIN; 1.
DR PANTHER; PTHR11588:SF239; TUBULIN ALPHA CHAIN; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01162; ALPHATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SMART; SM00865; Tubulin_C; 1.
DR SUPFAM; SSF55307; Tubulin C-terminal domain-like; 1.
DR SUPFAM; SSF52490; Tubulin nucleotide-binding domain-like; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU000352};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701, ECO:0000256|RuleBase:RU000352};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000352}.
FT DOMAIN 27..224
FT /note="Tubulin/FtsZ GTPase"
FT /evidence="ECO:0000259|SMART:SM00864"
FT DOMAIN 226..371
FT /note="Tubulin/FtsZ 2-layer sandwich"
FT /evidence="ECO:0000259|SMART:SM00865"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAQ19197.1"
FT NON_TER 384
FT /evidence="ECO:0000313|EMBL:AAQ19197.1"
SQ SEQUENCE 384 AA; 42624 MW; 30EC9FFE5FB8A099 CRC64;
LYCLEHGIQP DGQLPSDKTI GVEDDAFNTF FSETGAGKHV PRAVFVDLEP TVVDEVRTGT
YRQLFHPEQL ISGKEDAANN YARGHYTVGK ELIDLTLDRI RKLADQCTGL QGFLIFHSFG
GGTGAGFGSL LLERLSVDYG KKSKLEFTVY PSPQVSTAIV EPYNSILATH AMIDHSDCAF
MVDNEALYDL CRRALDIERP TYTNLNRLIG QVVSSLTASL RFDGALNVDF TEFQTNLVPY
ARIHFPICSY APVISAEKAY HEQLSVAEIT NSLFEPANMM VKCDPRHGKY MACTLLYRGD
VVPKDVSAAV ATIKTKRTIQ FVDWCPTGFK MGINYQPPTV VPGGDLAKVQ RAVCMLANTT
AIAEAWSRLD HKFDLMYAKR AFVH
//
