GenomeNet

Database: UniProt
Entry: Q6XMS0_RHOER
LinkDB: Q6XMS0_RHOER
Original site: Q6XMS0_RHOER 
ID   Q6XMS0_RHOER            Unreviewed;       207 AA.
AC   Q6XMS0;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   13-SEP-2023, entry version 50.
DE   RecName: Full=nitrile hydratase {ECO:0000256|ARBA:ARBA00013079};
DE            EC=4.2.1.84 {ECO:0000256|ARBA:ARBA00013079};
OS   Rhodococcus erythropolis (Arthrobacter picolinophilus).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Rhodococcus; Rhodococcus erythropolis group.
OX   NCBI_TaxID=1833 {ECO:0000313|EMBL:AAP57646.1};
RN   [1] {ECO:0000313|EMBL:AAP57646.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=870-AN019 {ECO:0000313|EMBL:AAP57646.1};
RX   PubMed=14532022; DOI=10.1128/AEM.69.10.5754-5766.2003;
RA   Brandao P.F., Clapp J.P., Bull A.T.;
RT   "Diversity of nitrile hydratase and amidase enzyme genes in Rhodococcus
RT   erythropolis recovered from geographically distinct habitats.";
RL   Appl. Environ. Microbiol. 69:5754-5766(2003).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an aliphatic amide = a nitrile + H2O; Xref=Rhea:RHEA:12673,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:18379, ChEBI:CHEBI:65285; EC=4.2.1.84;
CC         Evidence={ECO:0000256|ARBA:ARBA00001410};
CC   -!- SIMILARITY: Belongs to the nitrile hydratase subunit alpha family.
CC       {ECO:0000256|ARBA:ARBA00009363}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY223829; AAP57646.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6XMS0; -.
DR   GO; GO:0080109; F:indole-3-acetonitrile nitrile hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR   GO; GO:0006807; P:nitrogen compound metabolic process; IEA:InterPro.
DR   Gene3D; 3.90.330.10; Nitrile hydratase alpha /Thiocyanate hydrolase gamma; 1.
DR   InterPro; IPR036648; CN_Hdrase_a/SCN_Hdrase_g_sf.
DR   InterPro; IPR004232; CN_Hdrtase_a/SCN_Hdrlase_g.
DR   InterPro; IPR023900; CN_Hdrtase_asu/SCN_Hdrlase_gsu.
DR   InterPro; IPR018141; Nitrile_hydratase_asu.
DR   NCBIfam; TIGR01323; nitrile_alph; 1.
DR   Pfam; PF02979; NHase_alpha; 1.
DR   PIRSF; PIRSF001426; NHase_alpha; 1.
DR   SUPFAM; SSF56209; Nitrile hydratase alpha chain; 1.
PE   3: Inferred from homology;
KW   Iron {ECO:0000256|PIRSR:PIRSR001426-1};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|PIRSR:PIRSR001426-1}.
FT   DOMAIN          21..200
FT                   /note="Nitrile hydratase alpha /Thiocyanate hydrolase
FT                   gamma"
FT                   /evidence="ECO:0000259|Pfam:PF02979"
FT   BINDING         110
FT                   /ligand="Fe(3+)"
FT                   /ligand_id="ChEBI:CHEBI:29034"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001426-1"
FT   BINDING         113
FT                   /ligand="Fe(3+)"
FT                   /ligand_id="ChEBI:CHEBI:29034"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001426-1"
FT   BINDING         114
FT                   /ligand="Fe(3+)"
FT                   /ligand_id="ChEBI:CHEBI:29034"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001426-1"
FT   BINDING         115
FT                   /ligand="Fe(3+)"
FT                   /ligand_id="ChEBI:CHEBI:29034"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001426-1"
SQ   SEQUENCE   207 AA;  23014 MW;  3F6A21AF7010D6A5 CRC64;
     MSVTIDHTTE NAAPAQAPVS DRAWALFRAL DGKGLVPDGY VEGWKKTFEE DFSPRRGAEL
     VARAWTDPDF RQLLLTDGTA AVAQYGYLGP QGEYIVAVED TPTLKNVIVC SLCSCTAWPI
     LGLPPTWYKS FEYRARVVRE PRKVLFEMGT EIASDVEIRV YDTTAETRYM VLPQRPAGTE
     GWSQEQLQEI VTKDCLIGVA VPQVPTV
//
DBGET integrated database retrieval system