ID Q6Y1P0_DROSI Unreviewed; 526 AA.
AC Q6Y1P0;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 96.
DE SubName: Full=Notch {ECO:0000313|EMBL:AAP20437.1};
DE Flags: Fragment;
OS Drosophila simulans (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7240 {ECO:0000313|EMBL:AAP20437.1};
RN [1] {ECO:0000313|EMBL:AAP20437.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=10 {ECO:0000313|EMBL:AAP20436.1}, 11
RC {ECO:0000313|EMBL:AAP20437.1}, 13 {ECO:0000313|EMBL:AAP20448.1}, 14
RC {ECO:0000313|EMBL:AAP20438.1}, 15 {ECO:0000313|EMBL:AAP20439.1}, 19
RC {ECO:0000313|EMBL:AAP20449.1}, 27 {ECO:0000313|EMBL:AAP20450.1}, 29
RC {ECO:0000313|EMBL:AAP20442.1}, 3 {ECO:0000313|EMBL:AAP20451.1}, 35
RC {ECO:0000313|EMBL:AAP20444.1}, 36 {ECO:0000313|EMBL:AAP20452.1}, 39
RC {ECO:0000313|EMBL:AAP20445.1}, 48 {ECO:0000313|EMBL:AAP20453.1}, 5
RC {ECO:0000313|EMBL:AAP20447.1}, 63 {ECO:0000313|EMBL:AAP20454.1}, 65
RC {ECO:0000313|EMBL:AAP20455.1}, 7 {ECO:0000313|EMBL:AAP20446.1}, and 80
RC {ECO:0000313|EMBL:AAP20457.1};
RA Bauer DuMont V.L., Fay J.C., Calabrese P., Aquadro C.F.;
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAP20437.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=10 {ECO:0000313|EMBL:AAP20436.1}, 11
RC {ECO:0000313|EMBL:AAP20437.1}, 13 {ECO:0000313|EMBL:AAP20448.1}, 14
RC {ECO:0000313|EMBL:AAP20438.1}, 15 {ECO:0000313|EMBL:AAP20439.1}, 19
RC {ECO:0000313|EMBL:AAP20449.1}, 27 {ECO:0000313|EMBL:AAP20450.1}, 29
RC {ECO:0000313|EMBL:AAP20442.1}, 3 {ECO:0000313|EMBL:AAP20451.1}, 35
RC {ECO:0000313|EMBL:AAP20444.1}, 36 {ECO:0000313|EMBL:AAP20452.1}, 39
RC {ECO:0000313|EMBL:AAP20445.1}, 48 {ECO:0000313|EMBL:AAP20453.1}, 5
RC {ECO:0000313|EMBL:AAP20447.1}, 63 {ECO:0000313|EMBL:AAP20454.1}, 65
RC {ECO:0000313|EMBL:AAP20455.1}, 7 {ECO:0000313|EMBL:AAP20446.1}, and 80
RC {ECO:0000313|EMBL:AAP20457.1};
RX PubMed=15166145; DOI=10.1534/genetics.167.1.171;
RA DuMont V.B., Fay J.C., Calabrese P.P., Aquadro C.F.;
RT "DNA variability and divergence at the notch locus in Drosophila
RT melanogaster and D. simulans: a case of accelerated synonymous site
RT divergence.";
RL Genetics 167:171-185(2004).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY191391; AAP20436.1; -; Genomic_DNA.
DR EMBL; AY191392; AAP20437.1; -; Genomic_DNA.
DR EMBL; AY191393; AAP20438.1; -; Genomic_DNA.
DR EMBL; AY191394; AAP20439.1; -; Genomic_DNA.
DR EMBL; AY191397; AAP20442.1; -; Genomic_DNA.
DR EMBL; AY191399; AAP20444.1; -; Genomic_DNA.
DR EMBL; AY191400; AAP20445.1; -; Genomic_DNA.
DR EMBL; AY191401; AAP20446.1; -; Genomic_DNA.
DR EMBL; AY191402; AAP20447.1; -; Genomic_DNA.
DR EMBL; AY191403; AAP20448.1; -; Genomic_DNA.
DR EMBL; AY191404; AAP20449.1; -; Genomic_DNA.
DR EMBL; AY191405; AAP20450.1; -; Genomic_DNA.
DR EMBL; AY191406; AAP20451.1; -; Genomic_DNA.
DR EMBL; AY191407; AAP20452.1; -; Genomic_DNA.
DR EMBL; AY191408; AAP20453.1; -; Genomic_DNA.
DR EMBL; AY191409; AAP20454.1; -; Genomic_DNA.
DR EMBL; AY191410; AAP20455.1; -; Genomic_DNA.
DR EMBL; AY191411; AAP20456.1; -; Genomic_DNA.
DR EMBL; AY191412; AAP20457.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6Y1P0; -.
DR ChiTaRS; N; fly.
DR GO; GO:0005912; C:adherens junction; IEA:EnsemblMetazoa.
DR GO; GO:0016324; C:apical plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0009986; C:cell surface; IEA:EnsemblMetazoa.
DR GO; GO:1990433; C:CSL-Notch-Mastermind transcription factor complex; IEA:EnsemblMetazoa.
DR GO; GO:0005769; C:early endosome; IEA:EnsemblMetazoa.
DR GO; GO:0030139; C:endocytic vesicle; IEA:EnsemblMetazoa.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR GO; GO:0005770; C:late endosome; IEA:EnsemblMetazoa.
DR GO; GO:0005764; C:lysosome; IEA:EnsemblMetazoa.
DR GO; GO:0003682; F:chromatin binding; IEA:EnsemblMetazoa.
DR GO; GO:0035035; F:histone acetyltransferase binding; IEA:EnsemblMetazoa.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:EnsemblMetazoa.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:EnsemblMetazoa.
DR GO; GO:0050699; F:WW domain binding; IEA:EnsemblMetazoa.
DR GO; GO:0007015; P:actin filament organization; IEA:EnsemblMetazoa.
DR GO; GO:0007298; P:border follicle cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0043697; P:cell dedifferentiation; IEA:EnsemblMetazoa.
DR GO; GO:0008407; P:chaeta morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0060289; P:compartment boundary maintenance; IEA:EnsemblMetazoa.
DR GO; GO:0042688; P:crystal cell differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0002213; P:defense response to insect; IEA:EnsemblMetazoa.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
DR GO; GO:0046843; P:dorsal appendage formation; IEA:EnsemblMetazoa.
DR GO; GO:0009950; P:dorsal/ventral axis specification; IEA:EnsemblMetazoa.
DR GO; GO:0035162; P:embryonic hemopoiesis; IEA:EnsemblMetazoa.
DR GO; GO:0061331; P:epithelial cell proliferation involved in Malpighian tubule morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0035153; P:epithelial cell type specification, open tracheal system; IEA:EnsemblMetazoa.
DR GO; GO:0007455; P:eye-antennal disc morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0036099; P:female germ-line stem cell population maintenance; IEA:EnsemblMetazoa.
DR GO; GO:0030713; P:follicle cell of egg chamber stalk formation; IEA:EnsemblMetazoa.
DR GO; GO:0007440; P:foregut morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0060288; P:formation of a compartment boundary; IEA:EnsemblMetazoa.
DR GO; GO:0060250; P:germ-line stem-cell niche homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0007403; P:glial cell fate determination; IEA:EnsemblMetazoa.
DR GO; GO:0008347; P:glial cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0035172; P:hemocyte proliferation; IEA:EnsemblMetazoa.
DR GO; GO:0016348; P:imaginal disc-derived leg joint morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0048803; P:imaginal disc-derived male genitalia morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0008587; P:imaginal disc-derived wing margin morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0007474; P:imaginal disc-derived wing vein specification; IEA:EnsemblMetazoa.
DR GO; GO:0036335; P:intestinal stem cell homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0035171; P:lamellocyte differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0007616; P:long-term memory; IEA:EnsemblMetazoa.
DR GO; GO:0061382; P:Malpighian tubule tip cell differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0007498; P:mesoderm development; IEA:EnsemblMetazoa.
DR GO; GO:0060571; P:morphogenesis of an epithelial fold; IEA:EnsemblMetazoa.
DR GO; GO:0008045; P:motor neuron axon guidance; IEA:EnsemblMetazoa.
DR GO; GO:0046716; P:muscle cell cellular homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0007521; P:muscle cell fate determination; IEA:EnsemblMetazoa.
DR GO; GO:0048627; P:myoblast development; IEA:EnsemblMetazoa.
DR GO; GO:2000048; P:negative regulation of cell-cell adhesion mediated by cadherin; IEA:EnsemblMetazoa.
DR GO; GO:0045316; P:negative regulation of compound eye photoreceptor development; IEA:EnsemblMetazoa.
DR GO; GO:0010629; P:negative regulation of gene expression; IEA:EnsemblMetazoa.
DR GO; GO:0035204; P:negative regulation of lamellocyte differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0050768; P:negative regulation of neurogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0014019; P:neuroblast development; IEA:EnsemblMetazoa.
DR GO; GO:0007400; P:neuroblast fate determination; IEA:EnsemblMetazoa.
DR GO; GO:0014018; P:neuroblast fate specification; IEA:EnsemblMetazoa.
DR GO; GO:0007405; P:neuroblast proliferation; IEA:EnsemblMetazoa.
DR GO; GO:0048664; P:neuron fate determination; IEA:EnsemblMetazoa.
DR GO; GO:0048665; P:neuron fate specification; IEA:EnsemblMetazoa.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:EnsemblMetazoa.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0030720; P:oocyte localization involved in germarium-derived egg chamber formation; IEA:EnsemblMetazoa.
DR GO; GO:0007422; P:peripheral nervous system development; IEA:EnsemblMetazoa.
DR GO; GO:0042691; P:positive regulation of crystal cell differentiation; IEA:EnsemblMetazoa.
DR GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IEA:EnsemblMetazoa.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:EnsemblMetazoa.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:EnsemblMetazoa.
DR GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:EnsemblMetazoa.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR GO; GO:0048052; P:R1/R6 cell differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0048056; P:R3/R4 cell differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0045466; P:R7 cell differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0042686; P:regulation of cardioblast cell fate specification; IEA:EnsemblMetazoa.
DR GO; GO:0051489; P:regulation of filopodium assembly; IEA:EnsemblMetazoa.
DR GO; GO:0006110; P:regulation of glycolytic process; IEA:EnsemblMetazoa.
DR GO; GO:0040008; P:regulation of growth; IEA:EnsemblMetazoa.
DR GO; GO:2000035; P:regulation of stem cell division; IEA:EnsemblMetazoa.
DR GO; GO:0009608; P:response to symbiont; IEA:EnsemblMetazoa.
DR GO; GO:0016330; P:second mitotic wave involved in compound eye morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0016360; P:sensory organ precursor cell fate determination; IEA:EnsemblMetazoa.
DR GO; GO:0048863; P:stem cell differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0048190; P:wing disc dorsal/ventral pattern formation; IEA:EnsemblMetazoa.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR PANTHER; PTHR24123:SF33; ANKYRIN 2, ISOFORM U; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 2.
DR SMART; SM00248; ANK; 7.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 5.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023}.
FT REPEAT 157..189
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 190..215
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 224..256
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 257..289
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 290..322
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 379..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAP20437.1"
FT NON_TER 526
FT /evidence="ECO:0000313|EMBL:AAP20437.1"
SQ SEQUENCE 526 AA; 54933 MW; FB7C4C11019ACF04 CRC64;
DPHGQEMRNL NKQVAMQSQG VGQPGAHWSD DESDMPLPKR QRSDPVSGVG LGNNGGYASD
HTMVSEYEEA DQRVWSQAHL DVVDVRAIMT PPAHQDGGKH DVDARGPCGL TPLMIAAVRG
GGLDTGEDIE NNEDSTAQVI SDLLAQGAEL NATMDKTGET SLHLAARFAR ADAAKRLLDA
GADANCQDNT GRTPLHAAVA ADAMGVFQIL LRNRATNLNA RMHDGTTPLI LAARLAIEGM
VEDLITADAD INAADNSGKT ALHWAAAVNN TEAVNILLMH HANRDAQDDK DETPLFLAAR
EGSYEACKAL LDNFANREIT DHMDRLPRDV ASERLHHDIV RLLDEHVPRS PQMLSMTPQA
MIGSPPPGQQ QPQLITQPTV ISAGNGGNNG NGNASGKQSS QTAKQKAAKK AKLIEGSPDN
GLDATGSLRR KASSKKTSAA SKKAANLNGL NPGQLTGVSG VPGVPPSNSA AQAAAAAAAA
VAAMSHELEG SPVGVGMGGK LPSPYDTSSM YSNAMAAPLA NGNPNT
//