GenomeNet

Database: UniProt
Entry: Q6Y1P0_DROSI
LinkDB: Q6Y1P0_DROSI
Original site: Q6Y1P0_DROSI 
ID   Q6Y1P0_DROSI            Unreviewed;       526 AA.
AC   Q6Y1P0;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   24-JAN-2024, entry version 96.
DE   SubName: Full=Notch {ECO:0000313|EMBL:AAP20437.1};
DE   Flags: Fragment;
OS   Drosophila simulans (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7240 {ECO:0000313|EMBL:AAP20437.1};
RN   [1] {ECO:0000313|EMBL:AAP20437.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=10 {ECO:0000313|EMBL:AAP20436.1}, 11
RC   {ECO:0000313|EMBL:AAP20437.1}, 13 {ECO:0000313|EMBL:AAP20448.1}, 14
RC   {ECO:0000313|EMBL:AAP20438.1}, 15 {ECO:0000313|EMBL:AAP20439.1}, 19
RC   {ECO:0000313|EMBL:AAP20449.1}, 27 {ECO:0000313|EMBL:AAP20450.1}, 29
RC   {ECO:0000313|EMBL:AAP20442.1}, 3 {ECO:0000313|EMBL:AAP20451.1}, 35
RC   {ECO:0000313|EMBL:AAP20444.1}, 36 {ECO:0000313|EMBL:AAP20452.1}, 39
RC   {ECO:0000313|EMBL:AAP20445.1}, 48 {ECO:0000313|EMBL:AAP20453.1}, 5
RC   {ECO:0000313|EMBL:AAP20447.1}, 63 {ECO:0000313|EMBL:AAP20454.1}, 65
RC   {ECO:0000313|EMBL:AAP20455.1}, 7 {ECO:0000313|EMBL:AAP20446.1}, and 80
RC   {ECO:0000313|EMBL:AAP20457.1};
RA   Bauer DuMont V.L., Fay J.C., Calabrese P., Aquadro C.F.;
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAP20437.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=10 {ECO:0000313|EMBL:AAP20436.1}, 11
RC   {ECO:0000313|EMBL:AAP20437.1}, 13 {ECO:0000313|EMBL:AAP20448.1}, 14
RC   {ECO:0000313|EMBL:AAP20438.1}, 15 {ECO:0000313|EMBL:AAP20439.1}, 19
RC   {ECO:0000313|EMBL:AAP20449.1}, 27 {ECO:0000313|EMBL:AAP20450.1}, 29
RC   {ECO:0000313|EMBL:AAP20442.1}, 3 {ECO:0000313|EMBL:AAP20451.1}, 35
RC   {ECO:0000313|EMBL:AAP20444.1}, 36 {ECO:0000313|EMBL:AAP20452.1}, 39
RC   {ECO:0000313|EMBL:AAP20445.1}, 48 {ECO:0000313|EMBL:AAP20453.1}, 5
RC   {ECO:0000313|EMBL:AAP20447.1}, 63 {ECO:0000313|EMBL:AAP20454.1}, 65
RC   {ECO:0000313|EMBL:AAP20455.1}, 7 {ECO:0000313|EMBL:AAP20446.1}, and 80
RC   {ECO:0000313|EMBL:AAP20457.1};
RX   PubMed=15166145; DOI=10.1534/genetics.167.1.171;
RA   DuMont V.B., Fay J.C., Calabrese P.P., Aquadro C.F.;
RT   "DNA variability and divergence at the notch locus in Drosophila
RT   melanogaster and D. simulans: a case of accelerated synonymous site
RT   divergence.";
RL   Genetics 167:171-185(2004).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY191391; AAP20436.1; -; Genomic_DNA.
DR   EMBL; AY191392; AAP20437.1; -; Genomic_DNA.
DR   EMBL; AY191393; AAP20438.1; -; Genomic_DNA.
DR   EMBL; AY191394; AAP20439.1; -; Genomic_DNA.
DR   EMBL; AY191397; AAP20442.1; -; Genomic_DNA.
DR   EMBL; AY191399; AAP20444.1; -; Genomic_DNA.
DR   EMBL; AY191400; AAP20445.1; -; Genomic_DNA.
DR   EMBL; AY191401; AAP20446.1; -; Genomic_DNA.
DR   EMBL; AY191402; AAP20447.1; -; Genomic_DNA.
DR   EMBL; AY191403; AAP20448.1; -; Genomic_DNA.
DR   EMBL; AY191404; AAP20449.1; -; Genomic_DNA.
DR   EMBL; AY191405; AAP20450.1; -; Genomic_DNA.
DR   EMBL; AY191406; AAP20451.1; -; Genomic_DNA.
DR   EMBL; AY191407; AAP20452.1; -; Genomic_DNA.
DR   EMBL; AY191408; AAP20453.1; -; Genomic_DNA.
DR   EMBL; AY191409; AAP20454.1; -; Genomic_DNA.
DR   EMBL; AY191410; AAP20455.1; -; Genomic_DNA.
DR   EMBL; AY191411; AAP20456.1; -; Genomic_DNA.
DR   EMBL; AY191412; AAP20457.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6Y1P0; -.
DR   ChiTaRS; N; fly.
DR   GO; GO:0005912; C:adherens junction; IEA:EnsemblMetazoa.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0009986; C:cell surface; IEA:EnsemblMetazoa.
DR   GO; GO:1990433; C:CSL-Notch-Mastermind transcription factor complex; IEA:EnsemblMetazoa.
DR   GO; GO:0005769; C:early endosome; IEA:EnsemblMetazoa.
DR   GO; GO:0030139; C:endocytic vesicle; IEA:EnsemblMetazoa.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR   GO; GO:0005770; C:late endosome; IEA:EnsemblMetazoa.
DR   GO; GO:0005764; C:lysosome; IEA:EnsemblMetazoa.
DR   GO; GO:0003682; F:chromatin binding; IEA:EnsemblMetazoa.
DR   GO; GO:0035035; F:histone acetyltransferase binding; IEA:EnsemblMetazoa.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:EnsemblMetazoa.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:EnsemblMetazoa.
DR   GO; GO:0050699; F:WW domain binding; IEA:EnsemblMetazoa.
DR   GO; GO:0007015; P:actin filament organization; IEA:EnsemblMetazoa.
DR   GO; GO:0007298; P:border follicle cell migration; IEA:EnsemblMetazoa.
DR   GO; GO:0043697; P:cell dedifferentiation; IEA:EnsemblMetazoa.
DR   GO; GO:0008407; P:chaeta morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0060289; P:compartment boundary maintenance; IEA:EnsemblMetazoa.
DR   GO; GO:0042688; P:crystal cell differentiation; IEA:EnsemblMetazoa.
DR   GO; GO:0002213; P:defense response to insect; IEA:EnsemblMetazoa.
DR   GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
DR   GO; GO:0046843; P:dorsal appendage formation; IEA:EnsemblMetazoa.
DR   GO; GO:0009950; P:dorsal/ventral axis specification; IEA:EnsemblMetazoa.
DR   GO; GO:0035162; P:embryonic hemopoiesis; IEA:EnsemblMetazoa.
DR   GO; GO:0061331; P:epithelial cell proliferation involved in Malpighian tubule morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0035153; P:epithelial cell type specification, open tracheal system; IEA:EnsemblMetazoa.
DR   GO; GO:0007455; P:eye-antennal disc morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0036099; P:female germ-line stem cell population maintenance; IEA:EnsemblMetazoa.
DR   GO; GO:0030713; P:follicle cell of egg chamber stalk formation; IEA:EnsemblMetazoa.
DR   GO; GO:0007440; P:foregut morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0060288; P:formation of a compartment boundary; IEA:EnsemblMetazoa.
DR   GO; GO:0060250; P:germ-line stem-cell niche homeostasis; IEA:EnsemblMetazoa.
DR   GO; GO:0007403; P:glial cell fate determination; IEA:EnsemblMetazoa.
DR   GO; GO:0008347; P:glial cell migration; IEA:EnsemblMetazoa.
DR   GO; GO:0035172; P:hemocyte proliferation; IEA:EnsemblMetazoa.
DR   GO; GO:0016348; P:imaginal disc-derived leg joint morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0048803; P:imaginal disc-derived male genitalia morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0008587; P:imaginal disc-derived wing margin morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0007474; P:imaginal disc-derived wing vein specification; IEA:EnsemblMetazoa.
DR   GO; GO:0036335; P:intestinal stem cell homeostasis; IEA:EnsemblMetazoa.
DR   GO; GO:0035171; P:lamellocyte differentiation; IEA:EnsemblMetazoa.
DR   GO; GO:0007616; P:long-term memory; IEA:EnsemblMetazoa.
DR   GO; GO:0061382; P:Malpighian tubule tip cell differentiation; IEA:EnsemblMetazoa.
DR   GO; GO:0007498; P:mesoderm development; IEA:EnsemblMetazoa.
DR   GO; GO:0060571; P:morphogenesis of an epithelial fold; IEA:EnsemblMetazoa.
DR   GO; GO:0008045; P:motor neuron axon guidance; IEA:EnsemblMetazoa.
DR   GO; GO:0046716; P:muscle cell cellular homeostasis; IEA:EnsemblMetazoa.
DR   GO; GO:0007521; P:muscle cell fate determination; IEA:EnsemblMetazoa.
DR   GO; GO:0048627; P:myoblast development; IEA:EnsemblMetazoa.
DR   GO; GO:2000048; P:negative regulation of cell-cell adhesion mediated by cadherin; IEA:EnsemblMetazoa.
DR   GO; GO:0045316; P:negative regulation of compound eye photoreceptor development; IEA:EnsemblMetazoa.
DR   GO; GO:0010629; P:negative regulation of gene expression; IEA:EnsemblMetazoa.
DR   GO; GO:0035204; P:negative regulation of lamellocyte differentiation; IEA:EnsemblMetazoa.
DR   GO; GO:0050768; P:negative regulation of neurogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0014019; P:neuroblast development; IEA:EnsemblMetazoa.
DR   GO; GO:0007400; P:neuroblast fate determination; IEA:EnsemblMetazoa.
DR   GO; GO:0014018; P:neuroblast fate specification; IEA:EnsemblMetazoa.
DR   GO; GO:0007405; P:neuroblast proliferation; IEA:EnsemblMetazoa.
DR   GO; GO:0048664; P:neuron fate determination; IEA:EnsemblMetazoa.
DR   GO; GO:0048665; P:neuron fate specification; IEA:EnsemblMetazoa.
DR   GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:EnsemblMetazoa.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0030720; P:oocyte localization involved in germarium-derived egg chamber formation; IEA:EnsemblMetazoa.
DR   GO; GO:0007422; P:peripheral nervous system development; IEA:EnsemblMetazoa.
DR   GO; GO:0042691; P:positive regulation of crystal cell differentiation; IEA:EnsemblMetazoa.
DR   GO; GO:1900087; P:positive regulation of G1/S transition of mitotic cell cycle; IEA:EnsemblMetazoa.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:EnsemblMetazoa.
DR   GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:EnsemblMetazoa.
DR   GO; GO:0043525; P:positive regulation of neuron apoptotic process; IEA:EnsemblMetazoa.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblMetazoa.
DR   GO; GO:0048052; P:R1/R6 cell differentiation; IEA:EnsemblMetazoa.
DR   GO; GO:0048056; P:R3/R4 cell differentiation; IEA:EnsemblMetazoa.
DR   GO; GO:0045466; P:R7 cell differentiation; IEA:EnsemblMetazoa.
DR   GO; GO:0042686; P:regulation of cardioblast cell fate specification; IEA:EnsemblMetazoa.
DR   GO; GO:0051489; P:regulation of filopodium assembly; IEA:EnsemblMetazoa.
DR   GO; GO:0006110; P:regulation of glycolytic process; IEA:EnsemblMetazoa.
DR   GO; GO:0040008; P:regulation of growth; IEA:EnsemblMetazoa.
DR   GO; GO:2000035; P:regulation of stem cell division; IEA:EnsemblMetazoa.
DR   GO; GO:0009608; P:response to symbiont; IEA:EnsemblMetazoa.
DR   GO; GO:0016330; P:second mitotic wave involved in compound eye morphogenesis; IEA:EnsemblMetazoa.
DR   GO; GO:0016360; P:sensory organ precursor cell fate determination; IEA:EnsemblMetazoa.
DR   GO; GO:0048863; P:stem cell differentiation; IEA:EnsemblMetazoa.
DR   GO; GO:0048190; P:wing disc dorsal/ventral pattern formation; IEA:EnsemblMetazoa.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   PANTHER; PTHR24123:SF33; ANKYRIN 2, ISOFORM U; 1.
DR   PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   SMART; SM00248; ANK; 7.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 4.
DR   PROSITE; PS50088; ANK_REPEAT; 5.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023}.
FT   REPEAT          157..189
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          190..215
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          224..256
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          257..289
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REPEAT          290..322
FT                   /note="ANK"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          379..462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..406
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        431..462
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAP20437.1"
FT   NON_TER         526
FT                   /evidence="ECO:0000313|EMBL:AAP20437.1"
SQ   SEQUENCE   526 AA;  54933 MW;  FB7C4C11019ACF04 CRC64;
     DPHGQEMRNL NKQVAMQSQG VGQPGAHWSD DESDMPLPKR QRSDPVSGVG LGNNGGYASD
     HTMVSEYEEA DQRVWSQAHL DVVDVRAIMT PPAHQDGGKH DVDARGPCGL TPLMIAAVRG
     GGLDTGEDIE NNEDSTAQVI SDLLAQGAEL NATMDKTGET SLHLAARFAR ADAAKRLLDA
     GADANCQDNT GRTPLHAAVA ADAMGVFQIL LRNRATNLNA RMHDGTTPLI LAARLAIEGM
     VEDLITADAD INAADNSGKT ALHWAAAVNN TEAVNILLMH HANRDAQDDK DETPLFLAAR
     EGSYEACKAL LDNFANREIT DHMDRLPRDV ASERLHHDIV RLLDEHVPRS PQMLSMTPQA
     MIGSPPPGQQ QPQLITQPTV ISAGNGGNNG NGNASGKQSS QTAKQKAAKK AKLIEGSPDN
     GLDATGSLRR KASSKKTSAA SKKAANLNGL NPGQLTGVSG VPGVPPSNSA AQAAAAAAAA
     VAAMSHELEG SPVGVGMGGK LPSPYDTSSM YSNAMAAPLA NGNPNT
//
DBGET integrated database retrieval system