ID   Q6ZNQ9_HUMAN            Unreviewed;       280 AA.
AC   Q6ZNQ9;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   SubName: Full=cDNA FLJ27321 fis, clone TMS07849, highly similar to 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 2 {ECO:0000313|EMBL:BAC85441.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAC85441.1};
RN   [1] {ECO:0000313|EMBL:BAC85441.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Thymus {ECO:0000313|EMBL:BAC85441.1};
RA   Kawakami B., Sugiyama A., Takemoto M., Suzuki Y., Hata H., Nakagawa K.,
RA   Mizuno S., Morinaga M., Kawamura M., Sugiyama T., Irie R., Otsuki T.,
RA   Sato H., Nishikawa T., Nagai K., Isogai T., Sugano S.;
RT   "NEDO human cDNA sequencing project.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AK130831; BAC85441.1; -; mRNA.
DR   AlphaFoldDB; Q6ZNQ9; -.
DR   PeptideAtlas; Q6ZNQ9; -.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1230.10; Phospholipase C beta, distal C-terminal domain; 1.
DR   InterPro; IPR001192; PI-PLC_fam.
DR   InterPro; IPR014815; PLC-beta_C.
DR   InterPro; IPR042531; PLC-beta_C_sf.
DR   InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR   PANTHER; PTHR10336:SF10; 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-2; 1.
DR   PANTHER; PTHR10336; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN; 1.
DR   Pfam; PF00388; PI-PLC-X; 1.
DR   Pfam; PF08703; PLC-beta_C; 1.
DR   SUPFAM; SSF69989; C-terminal domain of PLC-beta; 1.
DR   PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT   DOMAIN          1..45
FT                   /note="Phosphatidylinositol-specific phospholipase C X"
FT                   /evidence="ECO:0000259|Pfam:PF00388"
FT   DOMAIN          84..248
FT                   /note="Phospholipase C-beta C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08703"
FT   REGION          21..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          98..148
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          175..239
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        45..62
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   280 AA;  31778 MW;  7B84A838D7F29747 CRC64;
     MAEYCRTIFG DMLLTEPLEK FPLKPGVPLP SPEDLRGKIL IKNKKNQFSG PTSSSKDTGG
     EAEGSSPPSA PAGEGTVWAG EEGTELLRQG EEQYECVLKR KEQHVAEQIS KMMELAREKQ
     AAELKALKET SENDTKEMKK KLETKRLERI QGMTKVTTDK MAQERLKREI NNSHIQEVVQ
     VIKQMTENLE RHQEKLEEKQ AACLEQIREM EKQFQKEALA EYEARMKGLE AEVKESVRAC
     LRTCFPSEAK DKPERACECP PELCEQDPLI AKADAQESRL
//