GenomeNet

Database: UniProt
Entry: Q6ZTA4
LinkDB: Q6ZTA4
Original site: Q6ZTA4 
ID   TRI67_HUMAN             Reviewed;         783 AA.
AC   Q6ZTA4; Q5TER7; Q5TER8; Q7Z4K7;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-AUG-2010, sequence version 3.
DT   16-APR-2014, entry version 86.
DE   RecName: Full=Tripartite motif-containing protein 67;
DE   AltName: Full=TRIM9-like protein;
GN   Name=TRIM67; Synonyms=TNL;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX   PubMed=16434393; DOI=10.1074/jbc.M512755200;
RA   Short K.M., Cox T.C.;
RT   "Subclassification of the RBCC/TRIM superfamily reveals a novel motif
RT   necessary for microtubule binding.";
RL   J. Biol. Chem. 281:8970-8980(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
RA   Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
RA   Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
RA   Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
RA   Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
RA   Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
RA   Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
RA   Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
RA   Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
RA   Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
RA   Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
RA   Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
RA   Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
RA   Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-744 (ISOFORM 1).
RC   TISSUE=Cerebellum;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cytoplasm,
CC       cytoskeleton (By similarity). Note=Microtubule-associated (By
CC       similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6ZTA4-3; Sequence=Displayed;
CC         Note=Gene prediction based on EST data;
CC       Name=2;
CC         IsoId=Q6ZTA4-2; Sequence=VSP_021359, VSP_021360;
CC   -!- SIMILARITY: Belongs to the TRIM/RBCC family.
CC   -!- SIMILARITY: Contains 2 B box-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 B30.2/SPRY domain.
CC   -!- SIMILARITY: Contains 1 COS domain.
CC   -!- SIMILARITY: Contains 1 fibronectin type-III domain.
CC   -!- SIMILARITY: Contains 1 RING-type zinc finger.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC86689.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AY253917; AAP69949.1; -; mRNA.
DR   EMBL; AL109810; CAI19160.1; -; Genomic_DNA.
DR   EMBL; AL109810; CAI19161.1; -; Genomic_DNA.
DR   EMBL; AL109810; CAI19162.1; -; Genomic_DNA.
DR   EMBL; AK126782; BAC86689.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001004342.3; NM_001004342.3.
DR   RefSeq; XP_005273195.1; XM_005273138.1.
DR   UniGene; Hs.655089; -.
DR   ProteinModelPortal; Q6ZTA4; -.
DR   SMR; Q6ZTA4; 1-31, 199-345, 512-606, 608-765.
DR   STRING; 9606.ENSP00000412124; -.
DR   PhosphoSite; Q6ZTA4; -.
DR   DMDM; 302393802; -.
DR   PaxDb; Q6ZTA4; -.
DR   PRIDE; Q6ZTA4; -.
DR   DNASU; 440730; -.
DR   Ensembl; ENST00000366653; ENSP00000355613; ENSG00000119283. [Q6ZTA4-3]
DR   Ensembl; ENST00000449018; ENSP00000400163; ENSG00000119283. [Q6ZTA4-2]
DR   GeneID; 440730; -.
DR   KEGG; hsa:440730; -.
DR   UCSC; uc009xfn.1; human. [Q6ZTA4-3]
DR   CTD; 440730; -.
DR   GeneCards; GC01P231298; -.
DR   H-InvDB; HIX0001690; -.
DR   HGNC; HGNC:31859; TRIM67.
DR   HPA; HPA034776; -.
DR   MIM; 610584; gene.
DR   neXtProt; NX_Q6ZTA4; -.
DR   PharmGKB; PA134947738; -.
DR   eggNOG; NOG260378; -.
DR   HOGENOM; HOG000007387; -.
DR   HOVERGEN; HBG062305; -.
DR   InParanoid; Q6ZTA4; -.
DR   KO; K10649; -.
DR   OMA; LPCARTI; -.
DR   PhylomeDB; Q6ZTA4; -.
DR   TreeFam; TF315216; -.
DR   GenomeRNAi; 440730; -.
DR   NextBio; 109477; -.
DR   PRO; PR:Q6ZTA4; -.
DR   ArrayExpress; Q6ZTA4; -.
DR   Bgee; Q6ZTA4; -.
DR   CleanEx; HS_TRIM67; -.
DR   Genevestigator; Q6ZTA4; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IEA:Ensembl.
DR   GO; GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
DR   GO; GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR   Gene3D; 2.60.40.10; -; 1.
DR   Gene3D; 3.30.40.10; -; 2.
DR   Gene3D; 4.10.45.10; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR003649; Bbox_C.
DR   InterPro; IPR008985; ConA-like_lec_gl_sf.
DR   InterPro; IPR017903; COS_domain.
DR   InterPro; IPR003961; Fibronectin_type3.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003877; SPRY_rcpt.
DR   InterPro; IPR000315; Znf_B-box.
DR   InterPro; IPR018957; Znf_C3HC4_RING-type.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   Pfam; PF00643; zf-B_box; 1.
DR   Pfam; PF00097; zf-C3HC4; 1.
DR   SMART; SM00502; BBC; 1.
DR   SMART; SM00336; BBOX; 2.
DR   SMART; SM00060; FN3; 1.
DR   SMART; SM00184; RING; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS51262; COS; 1.
DR   PROSITE; PS50853; FN3; 1.
DR   PROSITE; PS50119; ZF_BBOX; 2.
DR   PROSITE; PS00518; ZF_RING_1; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Complete proteome; Cytoplasm;
KW   Cytoskeleton; Metal-binding; Reference proteome; Repeat; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    783       Tripartite motif-containing protein 67.
FT                                /FTId=PRO_0000256864.
FT   DOMAIN      448    506       COS.
FT   DOMAIN      513    607       Fibronectin type-III.
FT   DOMAIN      589    780       B30.2/SPRY.
FT   ZN_FING       7     42       RING-type; degenerate.
FT   ZN_FING     206    253       B box-type 1; degenerate.
FT   ZN_FING     298    340       B box-type 2.
FT   COILED      345    382       Potential.
FT   COMPBIAS     59     65       Poly-Ala.
FT   COMPBIAS     74     96       Gly-rich.
FT   COMPBIAS    139    142       Poly-Ala.
FT   COMPBIAS    148    156       Poly-Ser.
FT   COMPBIAS    201    206       Poly-Ala.
FT   COMPBIAS    277    280       Poly-Gly.
FT   VAR_SEQ      42     81       Missing (in isoform 2).
FT                                /FTId=VSP_021359.
FT   VAR_SEQ     251    272       Missing (in isoform 2).
FT                                /FTId=VSP_021360.
FT   CONFLICT     22     22       C -> R (in Ref. 3; BAC86689).
FT   CONFLICT    679    679       M -> V (in Ref. 3; BAC86689).
SQ   SEQUENCE   783 AA;  83823 MW;  FC07A0E0B576D821 CRC64;
     MEEELKCPVC GSLFREPIIL PCSHNVCLPC ARTIAVQTPD GEQHLPQPLL LSRGSGLQAG
     AAAAASLEHD AAAGPACGGA GGSAAGGLGG GAGGGGDHAD KLSLYSETDS GYGSYTPSLK
     SPNGVRVLPM VPAPPGSSAA AARGAACSSL SSSSSSITCP QCHRSASLDH RGLRGFQRNR
     LLEAIVQRYQ QGRGAVPGTS AAAAVAICQL CDRTPPEPAA TLCEQCDVLY CSACQLKCHP
     SRGPFAKHRL VQPPPPPPPP AEAASGPTGT AQGAPSGGGG CKSPGGAGAG ATGGSTARKF
     PTCPEHEMEN YSMYCVSCRT PVCYLCLEEG RHAKHEVKPL GAMWKQHKAQ LSQALNGVSD
     KAKEAKEFLV QLKNILQQIQ ENGLDYEACL VAQCDALVDA LTRQKAKLLT KVTKEREHKL
     KMVWDQINHC TLKLRQSTGL MEYCLEVIKE NDPSGFLQIS DALIKRVQVS QEQWVKGALE
     PKVSAEFDLT LDSEPLLQAI HQLDFIQMKC RVPPVPLLQL EKCCTRNNSV TLAWRMPPFT
     HSPVDGYILE LDDGAGGQFR EVYVGKETLC TIDGLHFNST YNARVKAFNS SGVGPYSKTV
     VLQTSDVAWF TFDPNSGHRD IILSNDNQTA TCSSYDDRVV LGTAAFSKGV HYWELHVDRY
     DNHPDPAFGV ARASVVKDMM LGKDDKAWAM YVDNNRSWFM HCNSHTNRTE GGVCKGATVG
     VLLDLNKHTL TFFINGQQQG PTAFSHVDGV FMPALSLNRN VQVTLHTGLE VPTNLGRPKL
     SGN
//
DBGET integrated database retrieval system