ID Q6ZZI5_ACTTI Unreviewed; 491 AA.
AC Q6ZZI5;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Halogenase {ECO:0000313|EMBL:CAG15020.1};
DE SubName: Full=Halogenation protein CepH {ECO:0000313|EMBL:TWG09470.1};
GN ORFNames=FHX34_108185 {ECO:0000313|EMBL:TWG09470.1};
OS Actinoplanes teichomyceticus.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=1867 {ECO:0000313|EMBL:CAG15020.1};
RN [1] {ECO:0000313|EMBL:CAG15020.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15113000; DOI=10.1016/S1074-5521(04)00002-X;
RA Li T.L., Huang F., Haydock S.F., Mironenko T., Leadlay P.F., Spencer J.B.;
RT "Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin:
RT characterization of two glycosyltransferases and the key acyltransferase.";
RL Chem. Biol. 11:107-119(2004).
RN [2] {ECO:0000313|EMBL:TWG09470.1, ECO:0000313|Proteomes:UP000320239}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 43866 {ECO:0000313|EMBL:TWG09470.1,
RC ECO:0000313|Proteomes:UP000320239};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the flavin-dependent halogenase family.
CC Bacterial tryptophan halogenase subfamily.
CC {ECO:0000256|ARBA:ARBA00038396}.
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DR EMBL; AJ632270; CAG15020.1; -; Genomic_DNA.
DR EMBL; VIWY01000008; TWG09470.1; -; Genomic_DNA.
DR AlphaFoldDB; Q6ZZI5; -.
DR OrthoDB; 103324at2; -.
DR Proteomes; UP000320239; Unassembled WGS sequence.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR Gene3D; 3.30.9.100; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR PANTHER; PTHR43747:SF1; FAD-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR Pfam; PF04820; Trp_halogenase; 2.
DR PRINTS; PR00420; RNGMNOXGNASE.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000320239}.
SQ SEQUENCE 491 AA; 54076 MW; 6B94BC76148A1A9F CRC64;
MPVEEFDVVV AGGGPAGSTV ATLVAMQGHR VLLLEKETFP RYQIGESLLP STVHGVCRML
GVSDELAAAG FPVKRGGTFR WGARPEPWTF SFAVSPLMNG PTSFAYQVER ARFDEILLRN
AQRKGVDVRE GCSVTGVIEG DERITGVRYT DPDGGEHEVS ARFVVDASGN KSRLYSQVGG
VRNYSEFFRS LALFGYFENG KRLPEPYSGN ILSVAFDSGW FWYIPLSDTM TSVGAVVRRE
MAEKIQGDRE KALQALIAEC PLISDYLADA RRITTGRYGE LRVRKDYSYH QTSYWRPGMI
LVGDAACFVD PVFSSGVHLA TYSALLAARS INSVLAEDLD EKTALSEFEA RYRREYGVFY
EFLVSFYQMN VNEESYFWQA KKVTNNKHTE IESFVELIGG VSSGEAALAT AGRIAERSAE
FAAAVDQMAA SADGNMVPMY KSEVVKQVMQ EGGQVQMKAV LGADAEPELP LFPGGLVVSP
DGMKWLPYRP A
//
