ID Q704P5_BOVIN Unreviewed; 311 AA.
AC Q704P5;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha-1C {ECO:0000256|ARBA:ARBA00024095};
DE AltName: Full=Voltage-gated calcium channel subunit alpha Cav1.2 {ECO:0000256|ARBA:ARBA00030570};
DE Flags: Fragment;
GN Name=caV1.2 {ECO:0000313|EMBL:CAF18236.1};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:CAF18236.1};
RN [1] {ECO:0000313|EMBL:CAF18236.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Adrenal medulla {ECO:0000313|EMBL:CAF18236.1};
RX PubMed=15450357; DOI=10.1016/j.neuroscience.2004.06.042;
RA Benavides A., Calvo S., Tornero D., Gonzalez-Garcia C., Cena V.;
RT "Adrenal medulla calcium channel population is not conserved in bovine
RT chromaffin cells in culture.";
RL Neuroscience 128:99-109(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma, T-tubule
CC {ECO:0000256|ARBA:ARBA00024012}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU003808}. Perikaryon
CC {ECO:0000256|ARBA:ARBA00004484}. Postsynaptic density membrane
CC {ECO:0000256|ARBA:ARBA00034112}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. CACNA1C subfamily. {ECO:0000256|ARBA:ARBA00024028}.
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DR EMBL; AJ621048; CAF18236.1; -; mRNA.
DR AlphaFoldDB; Q704P5; -.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0098839; C:postsynaptic density membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030315; C:T-tubule; IEA:UniProtKB-SubCell.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF10; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1C; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR00167; CACHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 2: Evidence at transcript level;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU003808};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Postsynaptic cell membrane {ECO:0000256|ARBA:ARBA00023257};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..311
FT /note="Voltage-dependent L-type calcium channel subunit
FT alpha-1C"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004283001"
FT TRANSMEM 68..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 67..309
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CAF18236.1"
FT NON_TER 311
FT /evidence="ECO:0000313|EMBL:CAF18236.1"
SQ SEQUENCE 311 AA; 36045 MW; E7DDC19928450AE2 CRC64;
RSFFMMNIFV GFVIVTFQEQ GEQEYKNCEL DKNQRQCVEY ALKARPLRRY IPKNQHQYKV
WYVVNSTYFE YLMFVLILLN TICLAMQHYG QSCLFKIAMN ILNMLFTGLF TVEMVLKLIA
FKPKGYFSDP WNVFDFLIVI GSVIDVILSE TNPAEHTQCS PFMNAEENSR ISITFFRLFR
VMRLVKLLTR GEGVRTLLWT FIKSFQAVPY VALLIVMLFF IYAVIGMQVF GKIALNDTTE
INRNNNFQTF PQAVLLLFRC ATGEAWQDIM LASMHGKKCA PESEPGNSTE GETPCGSSFA
VFYFISFYMD P
//
