ID Q70KD1_MICEC Unreviewed; 341 AA.
AC Q70KD1;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=Putative NAD dependent dehydrogenase {ECO:0000313|EMBL:CAE06510.1};
DE SubName: Full=Putative gentamicin oxidoreductase {ECO:0000313|EMBL:CAF31432.1};
GN Name=gtmC {ECO:0000313|EMBL:CAE06510.1};
GN Synonyms=genD2 {ECO:0000313|EMBL:CAF31432.1};
OS Micromonospora echinospora (Micromonospora purpurea).
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=1877 {ECO:0000313|EMBL:CAE06510.1};
RN [1] {ECO:0000313|EMBL:CAE06510.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 15835 {ECO:0000313|EMBL:CAE06510.1};
RX PubMed=14757238; DOI=10.1016/S0378-1097(03)00881-4;
RA Kharel M.K., Basnet D.B., Lee H.C., Liou K., Woo J.S., Kim B.-G.,
RA Sohng J.K.;
RT "Isolation and characterization of the tobramycin biosynthetic gene cluster
RT from Streptomyces tenebrarius.";
RL FEMS Microbiol. Lett. 230:185-190(2004).
RN [2] {ECO:0000313|EMBL:CAF31432.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=DSM 43036 {ECO:0000313|EMBL:CAF31432.1};
RA Aboshanab K.M.A., Schmidt-Beissner H., Wehmeier U.F., Welzel K., Vente A.,
RA Piepersberg W.;
RT "Cloning and sequencing of the gentamicin biosynthetic gene cluster from
RT Micromonospora echinospora DSM 43036.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CAE06510.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 15835 {ECO:0000313|EMBL:CAE06510.1};
RA Sohng J.K.;
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0007829|PDB:6NOR}
RP X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS).
RX PubMed=30995396; DOI=10.1021/acschembio.9b00115;
RA de Araujo N.C., Bury P.D.S., Tavares M.T., Huang F., Parise-Filho R.,
RA Leadlay P., Dias M.V.B.;
RT "Crystal Structure of GenD2, an NAD-Dependent Oxidoreductase Involved in
RT the Biosynthesis of Gentamicin.";
RL ACS Chem. Biol. 14:925-933(2019).
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DR EMBL; AJ575934; CAE06510.1; -; Genomic_DNA.
DR EMBL; AJ628149; CAF31432.1; -; Genomic_DNA.
DR PDB; 6NOR; X-ray; 2.40 A; A/B/C/D/E/F=1-341.
DR PDBsum; 6NOR; -.
DR AlphaFoldDB; Q70KD1; -.
DR SMR; Q70KD1; -.
DR KEGG; ag:CAF31432; -.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43708; CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG); 1.
DR PANTHER; PTHR43708:SF5; CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED; 1.
DR Pfam; PF01408; GFO_IDH_MocA; 1.
DR Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:6NOR}.
FT DOMAIN 6..120
FT /note="Gfo/Idh/MocA-like oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01408"
FT DOMAIN 142..339
FT /note="Gfo/Idh/MocA-like oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02894"
SQ SEQUENCE 341 AA; 36507 MW; 0EC99F66ABB26720 CRC64;
MVERLGVAVV GGGFMGGVHA EVLTADPRVD LRWVVDRDER VGTDLATRFG ARVTTTLDEA
LADDTVRFVV VATPAATHEP IAAQVIAAGR NVLVEKPLVL STGHARQLAA AAHERGVVLA
HGGNFVYAPK FVRAHELAAD REALGTVHSV RVAFRTSGPD TDWFRSKATA GGGALTDLGW
HAVELCRWML GKPAIRAVTA CTRQLSAAGD VEDQGVVLIE FADGAIGQCD VSWACPGGEQ
LTVEVIGTEG LVTADLWQGM GVEAYTNTKF GAVWEPNQGW LRPEWEWIRN SGYVHQDRQV
VDAVLDGRPM THTPDDAVAV VETLEAAYRS AADGRKVEMN A
//