GenomeNet

Database: UniProt
Entry: Q70LM5
LinkDB: Q70LM5
Original site: Q70LM5 
ID   LGRC_BREPA              Reviewed;        7756 AA.
AC   Q70LM5;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   19-FEB-2014, entry version 51.
DE   RecName: Full=Linear gramicidin synthase subunit C;
DE   Includes:
DE     RecName: Full=ATP-dependent valine adenylase;
DE              Short=ValA;
DE     AltName: Full=Valine activase;
DE   Includes:
DE     RecName: Full=ATP-dependent D-valine adenylase;
DE              Short=D-ValA;
DE     AltName: Full=D-valine activase;
DE   Includes:
DE     RecName: Full=Valine racemase [ATP-hydrolyzing];
DE              EC=5.1.1.-;
DE   Includes:
DE     RecName: Full=ATP-dependent tryptophan adenylase;
DE              Short=TrpA;
DE     AltName: Full=Tryptophan activase;
DE   Includes:
DE     RecName: Full=ATP-dependent tryptophan/phenylalanine/tyrosine adenylase;
DE              Short=Trp/Phe/TyrA;
DE     AltName: Full=Tryptophan/phenylalanine/tyrosine activase;
GN   Name=lgrC;
OS   Brevibacillus parabrevis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae;
OC   Brevibacillus.
OX   NCBI_TaxID=54914;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 8185 / DSM 362 / JCM 20017 / NBRC 3331 / NCDO 717 / NCIMB
RC   8598 / IAM 1031;
RX   PubMed=14670971; DOI=10.1074/jbc.M309658200;
RA   Kessler N., Schuhmann H., Morneweg S., Linne U., Marahiel M.A.;
RT   "The linear pentadecapeptide gramicidin is assembled by four
RT   multimodular nonribosomal peptide synthetases that comprise 16 modules
RT   with 57 catalytic domains.";
RL   J. Biol. Chem. 279:7413-7419(2004).
CC   -!- FUNCTION: Activates the 7th to 12th amino acids (Val, D-Val, Trp,
CC       D-Leu, Xaa and D-Leu) in linear gramicidin and catalyzes the
CC       formation of the peptide bond between them. This enzyme is also
CC       responsible for the epimerization of the 8th (D-Val), the 10th (D-
CC       Leu) and 12th (D-Leu) amino acids. The 11th (Xaa) amino acid is
CC       Trp in linear gramicidin A; Phe in linear gramicidin B and Tyr in
CC       linear gramicidin C.
CC   -!- COFACTOR: Binds 6 phosphopantetheines covalently (Potential).
CC   -!- PATHWAY: Antibiotic biosynthesis; gramicidin S biosynthesis.
CC   -!- SUBUNIT: Large multienzyme complex composed of 4 subunits; LgrA,
CC       LgrB, LgrC and LgrD.
CC   -!- DOMAIN: Six module-bearing peptide synthase with a C-terminal
CC       epimerization domain. Each module incorporates one amino acid into
CC       the peptide product and can be further subdivided into domains
CC       responsible for substrate adenylation, thiolation, condensation
CC       (not for the initiation module), and epimerization (optional).
CC   -!- MISCELLANEOUS: Linear gramicidin is a pentadecapeptide antibiotic
CC       produced during sporulation.
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme
CC       family.
CC   -!- SIMILARITY: Contains 6 acyl carrier domains.
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DR   EMBL; AJ566197; CAD92851.1; -; Genomic_DNA.
DR   ProteinModelPortal; Q70LM5; -.
DR   UniPathway; UPA00102; -.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1200.10; -; 6.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR009081; Acyl_carrier_prot-like.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR006162; PPantetheine_attach_site.
DR   Pfam; PF00501; AMP-binding; 6.
DR   Pfam; PF13193; AMP-binding_C; 6.
DR   Pfam; PF00668; Condensation; 9.
DR   Pfam; PF00550; PP-binding; 6.
DR   SMART; SM00823; PKS_PP; 6.
DR   SUPFAM; SSF47336; SSF47336; 6.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 6.
DR   TIGRFAMs; TIGR01720; NRPS-para261; 3.
DR   PROSITE; PS50075; ACP_DOMAIN; 6.
DR   PROSITE; PS00455; AMP_BINDING; 6.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 5.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Isomerase; Ligase; Multifunctional enzyme;
KW   Phosphopantetheine; Phosphoprotein; Repeat.
FT   CHAIN         1   7756       Linear gramicidin synthase subunit C.
FT                                /FTId=PRO_0000193091.
FT   DOMAIN      982   1049       Acyl carrier 1.
FT   DOMAIN     2047   2113       Acyl carrier 2.
FT   DOMAIN     3562   3629       Acyl carrier 3.
FT   DOMAIN     4626   4692       Acyl carrier 4.
FT   DOMAIN     6146   6213       Acyl carrier 5.
FT   DOMAIN     7205   7271       Acyl carrier 6.
FT   MOD_RES    1012   1012       O-(pantetheine 4'-phosphoryl)serine (By
FT                                similarity).
FT   MOD_RES    2077   2077       O-(pantetheine 4'-phosphoryl)serine (By
FT                                similarity).
FT   MOD_RES    3592   3592       O-(pantetheine 4'-phosphoryl)serine (By
FT                                similarity).
FT   MOD_RES    4656   4656       O-(pantetheine 4'-phosphoryl)serine (By
FT                                similarity).
FT   MOD_RES    6176   6176       O-(pantetheine 4'-phosphoryl)serine (By
FT                                similarity).
FT   MOD_RES    7235   7235       O-(pantetheine 4'-phosphoryl)serine (By
FT                                similarity).
SQ   SEQUENCE   7756 AA;  866321 MW;  C0EA2EAB6AAC5C7B CRC64;
     MNSMGDLTDL YTLTPLQEGM LFHSLYSEGS AYMIQTTAIL TGELDIVPFE KAWKKVIQRH
     SILRTGFIWE ETEKPLQAVF ESVPFSIRQK DWSSYGSDEQ ESMLAAFLQN EKAAGFDLSE
     APLMRVTIIK LGEAVHRLIW SFHHLLLDGW SSPIVFQEVL DFYEAYRQGK DLRLPQARPF
     KDYVSWLRRQ DKTASEQFWR EFLGPMENPT PIPFETHAKR TAGHEGLEKQ IGEATRALTG
     QVTKALAKLA RTNKVTVNTI VQGAWAILLS RLSGEENVVY GVTGSGRPSD LPGVEQMVGM
     FINTLPMKAK IEPEQSLADW FKALQEQQSK VRQYEYTSLV DIQGWTDVPR GTPLFESIFV
     FENYPLGEED EKEVGFTISA VQHFQEVDNP LTVVGIPGDP FSIKMMYATD RFEQAAIERT
     LDQLALILEA IVDNPERSLS ALSLLRPEER QHLLVGLNDT ATNYPSDKTV HQLFAETAAR
     HPERIAAVAG DQQLTYAELE ARANQLANYL QKQGVEAGTL VGLCVDRSLD MLIGLLAILK
     AGGAYVPIDP AYPEERLAFM LADAKISILL TQKHLGKQWK GRKRRTVYLD RDAKKWAEES
     PLAPDVDTTK DSLAYVIYTS GSTGTPKGVL AVHRGVVRLG QKTRTTSPIS EADVFLQAST
     VSFDAATFEI WGALLNGAKL VLMPPDLPSL DELGEAIVQH KVTTLWLTAG LFSIMVDHNA
     DYLRGVRQLL VGGDVVSVPH VRKVLALGGV TVINGYGPTE NTTFTCCYPV TELSEDITSF
     PIGRPISNTT VYVLDKHKQP VPYGAAGELY IGGDGLALGY LNNAELTAER FVENPFDPQK
     GSRLYRTGDL VRYLPNGTIE FIGRIDNQVK IRGFRIELGE VEAALALHPE VSETVVMARE
     NDRGEKHLTA YVTVAKDDAP EVADLQAWLK TKLPEYMVPS AYVFLDAMPL TANGKIDRRR
     LPEPEWGNRS ETKAYTEPRN QAEELIASIW SQVLGVEKVG IHDNFFELGG HSLLATRVIS
     RLREVFGVEQ SVRSIFEHPT IDAWSEQTAA LQLGGPGTDD SSTQIQPVPR DGALPLSFAQ
     QRLWFFDQLM PDNPMYNIPF ALRLQGELDV AAWEKSLQAI IARHESLRTT FTDIDGQAVQ
     VIHPQLDWKL DTVDLRDRSS EEKQQASARL AADDAARPFD LRQGPLMRAT MIRTEEQAHV
     FLINMHHIVS DGWSVGVFLR ELFAHYEAYS KGEVPQLAPM PIQYADFAAW QREWLEGEVL
     EQQVAYWKEK LGGAEPLLAL PTDRPRPALQ SYEGATYTTS FSHDLLAKLK KLSKEAQHDL
     VHDIARRFPN VLYRYSGQED IVVGSPVAGR NRQETEKLIG FFVNTLALRT SLSGDLPFTE
     LLARVRETAL AAYAHQDVPF EKLVDELQLE RSLSYSQLFQ VMFVLQNFPL EDVETAGLHV
     APVDTESHLT TSKFDLTLTM REKEDTLVAA FEYSTDLFDR TTIERMAEHL QHLLASIVTQ
     PEASLDQLAL LGESEWNRLV VEQNETATDY PRDKTAHQLF AETAARYPER IAAVAGDQQL
     TYAELDTKAN QLANYLQKQG VEAGTLVGLC VDRSLDMLVG LLAILKAGGA YVPLDPAYPE
     ERLAFMLADA NVSILLTQKH LGKQWKGRKR RTVYLDRDAK KWTAESPLAP AVDATKDSLA
     YVIYTSGSTG TPKGVLVAHR GIVRLVKNTN YVTITEEDVF LQASTVSFDA ATFEIWGALL
     NGAKLVLMPP DLPSLDELGE AIVQHKVTTL WLTAGLFSIM VDHNADYLRG VRQLLVGGDV
     VSVPHVRKVL ALDGVTVING YGPTENTTFT CCYPVTELAE EITSFPIGRP ISNTTVYVLD
     KNRQPVPLGV AGELYIGGDG LASGYLNNPE LTAERFVDNP FDPQKASRLY RTGDLVRYLP
     DGAIEFIGRI DNQVKIRGFR IELGEIETAL LRHPAVQEAF LMVREDAPGD KRLAAYLVFA
     GGQTVEPVEM RSYLKDKLPE YMIPSAFVQM DSFPLTPNGK VDRRALPTPE YARSEAASGY
     VAPATELEVK LADIWKTVLG VADVGIHDNF FELGGDSILS IQIVARANQL GIRLTPKQLF
     ENQTIAELLR VVADSSQLPH TKWENEQGIV TGNVPLTPIQ KWFFAADQPS LHHWNQSLLL
     TVQQPVDVSV LERAIASLLS HHDALRMSFS FVDGAWTQQM NGLGDHTPFR CVDLSDLSTQ
     EQEQAARLEE IASEVQASLN IAEGNVVQAV YFNLGEQKAG RLLLVVHHLV VDGVSWRILL
     EDLQHAYEQL ANHADVSFPA KTTSFKMWAE KLADYADSDA LEQEKAYWLQ QSSGGSPLPV
     DHPYEPNENT EAAAKQVTLS LRADETRALL HETLTAYRLQ INDVLLAALA KAMQRWTGQK
     TLHVHLEGHG REEIIEGADL SRTVGWFTSM YPVQLDFDQS KPWGHVLKAV KEQLRHIPQK
     GIGYGILQYL SNDDEWKEQL QAYTKPEISF NYLGQFDQVV SAGAKFAMAE ESRGANIAAD
     AIRAHLIDVN SAISGEQLHI TWMYNANIHN QETIEALARD YMESLREIME HCRSEEAGGY
     TPSDFPLARL DQRAIDNYVG RDRSIENVYP LTPLQEGMLF HSLYEHAGGD YVVQFSMTMH
     HVEVDVFQQA WQKVVDRHSI LRTSFIWDGV STPHQIVRKH VQVVVDEQDW RHVPADQQKA
     EWDAFLEEDR KRSFAITEPP LMRWTLLRIS DTAYRFIWSF HHVLLDGWSV PLVMKDWFAA
     YMALADGKDI QFGAVHPFSQ YVAWIQRQDL QAAERFWRNH LKGIYAPTQV NFGQTVQPVG
     ETKSYDERSI RFSAERTREL QAFARQHQVT LNTLVQSAWA MILGTYSKEA DVVFGATGSG
     RPADLPGVEN MVGLFINTLP IRVTLDPGKK VREWLRELQE LQVELRQYEY TPLVDIHGWS
     EMARNAPLFE SIFIFENYPI DESVKEVDHS FQIADVDSVE QTNYPLTVVC GPGAEFLVKI
     KFDQSRFDGG RIERVLEQMT LLLQSMTANP DQLLADVNMI SQSEQKQVLI EWNETKVDYP
     TGLCVQQAFE QQVEKTPDAV ALIYKDVELT YADLNQRANQ LAHRLLAQEV KPDTLVGICV
     ERSPEMIIGI FGVMKAGAAY VPIDPALPQE RIAYMVEDSQ ASILLTQQSL AELLPKTQAR
     VICLDGDSLA NEPVANPASE VTEQNLAYVM YTSGSTGLPK GVMVEHHSVV NLAHALIEAF
     RIQPSSRVLQ FTSFSFDVSV SEIVMALLAG AALVIEDREV LLPGPELISV LQQKRITTVS
     MVSSVLAALP AADLPDLQTL IVGGEAPSRE LVARYADRRQ FFNCYGPTEA TVCSTMMLCN
     AGMKSAPIGR PLANATLYVL DANQKPVPVG VPGELYIGGK GLARGYWNRP ELTAERFIAH
     PFGAKGERLY RTGDLVRYLP DGNLEFLGRI DTQVKIRGYR IELGEIESAL SQHPAIQEAV
     VIAWEQRLAA YMVAAGEAQP AAEELARYLK ETLPDYMIPA GFVFMDAIPL TVNGKVDRRA
     LPAPDWGILA TRQEYVAPRT PTEEMVANIW AQLLSVEKIG VHDDFFERGG HSLLATQAIS
     RLRQAFGVEL PLRMLFDHPT TAAISTQIAS LLQGETALRS QPIVPVPRDQ HVPLSFAQQR
     LWFLDRLIPN SFLYNIPSAA RLHGELDVEA WERSLKLLIQ RHESLRTTFS DRDGEAVQII
     HPAIEWSLGR VDLREWAEAE REAKALQLAI EDAKRPFDLE RGPLLRASLL VMAQQEYVFL
     LNLHHIVADG WSMNVFMEEL VTIYEALSAG ETPQLAELPL QYADYAAWQR DWLQGDVLEQ
     QLAYWKAKVG GAEPLLALPT DRPRPAVQSH KGAMHTITLP AERLAALKTL SREEGSTLFM
     TLLAAFQTLL YRYSGQSDIV VGSPVAGRNR QETESLIGFF INTLAMRTDL SGEPTFRDLL
     GKVRETALEA YAHQDLPFEK LVDELELERS LSYSPLFQVM FVLQNIPMDA QALSHIRLEP
     FHIGQEGVSA KFDITLTTVE LPAGLMATFE YNTDLFDPAT IERMAGHYAN LLAAVSVNPL
     QPITAIPLVS DQERKQVLFQ WNDTSVPSER DTCVHEQVAR IAQQLPNQLA VVSDEGQITY
     AELDAKANQV ANYLHKQGII SETLVGVCLD RSIDMLVAQL GILKAGGAYV PMDPAYPQER
     LAFMMQDAEM PVVLTQEHLL AQLPEARATF LCLDRDWSLI AEESDVAPVI ATNRDNLAYV
     IYTSGSTGTP KGVEIEHAAL LNLVSWHQRA YEVGAEDRAT QIAGTAFDAS VWEIWPYLTK
     GATLYLPSEE IRLVPEQLRD WLVASGITIS FLPTPLAERL LTLEWPSDAK LRYMLTGGDK
     LHDYPPATLP FVLANQYGPT ENAVVATAGI VPAAAGQVSA PSIGRPIDNV QVYVLDEKLQ
     PVPIGVAGEL YIAGDSLARG YLHRPDLTRE RFIANPYGQK AGARMYKTGD LVRYLPDGNI
     EFIGRADDQV SIRGFRVELG EIETALYSHP AVKETIVLVR EDMPGMKRLV AYIVQREGQE
     GQAVQAGDFR SYLKELLPEY MVPAAFVFMA DLPLTPNGKV DRRALPAPDL FNSEADGTYV
     APATELEIKL AHIWKNVLGL ADVGIHDNFF ELGGDSILSI QIVSRANQAG IRLTPKQLLA
     NQTIAELASV ATVTDESEAT KLPNEQGIVT GDVPLTPIQT WFFASEQPSV HHWNQSLLLT
     VQQPVDLAVL ERTIECLLAH HDALRMRYSR TEQGWTQRIE GLPETIPFRS VDLSAFPTTA
     EQEMRLEEIA SEVQASLDLT EGPVVQAVYF QLGAEQPGRL LIVAHHLVVD GVSWRILLED
     LQTAYEQLAK GQAVQLAAKT TSFKTWAEQL RLYATSEALR QEKAFWLEQM DEVKPLPIDR
     IFEPSENTEA TVKQVMLSLN AEETRALLQD TLSPYRLQIN DVLLAALTKA LHRWTGEQTV
     AIHLEGHGRE ELIEGADLSR TVGWFTSLYP VQLSVDPTKP WGDTLKAVKE QLRSIPNKGV
     GYGILRYLSE DAELQKRLAE KAQAEISFNY LGQFDQAVVP ESKFGMAQEA RGANVGQQAI
     RQHLLDVNSV IAGEQLHVTW MYSENIHEEA TIQQLAHNYL EALREIIAHG QSEAAGGYTP
     SDFPLARMDQ RALDKYLGQN RSIENVYPLS PLQGGMLFHS LYEQEGGDYV VQLAMTVEGL
     DVEAFEQAWQ KVVDRHSILR TSFIWEGLTE PHQVVRKQVK ACVEKIDLRH LTPDQQKAEL
     SEYLAADRRR SFEIAVAPLM RWTLFRLSES AYRFTWSFHH VLLDGWSIPI VLKDWFSAYL
     SLAEGKEVAH SFVQPFAHYV EWVQRQDLQA AEQFWREQLA GFYEPTPLAM GNSTGGRADL
     PKGYEEQEIR LAKDATARLQ AFVRTHQLTL NTLVQGAWAL MLGRYGGTDD VVFGATGSGR
     PADLPGVESM VGLFINTLPI RVALDANQSV REWLRGMQEQ QVELRQYEYT PLVDIQGWSE
     MTRNTALFES IFIFENYPIG ESVKDEQHQL RLSDVETIEQ TNYPLTVVCG PGEELIVKIK
     YEQNRFAPEQ IERVLQQMSQ LLQDMTAKPE QRLQDVSMIS ERERQQVLVD WNETSVAYPQ
     QLCVHQAFEQ QVEKTPDAVA LVYKDVELTY AELNERANQL AHRLLAEGVK PDELVGICVE
     RSPEMIVAFL GVMKAGAAYV PLDPAHPQER IAYMIEDSQA SVLLTQASLT DRLPASSRQV
     ICLDSDELAN EPVTNAETSV GEHNLAYVIY TSGSTGLPKG VMIEHRSVIN LAYDLIRHFQ
     IDATSRVLQF ISFSFDVSVS EIVMSLLAGA TLVIEDRESL LPGPELIRVL QEQRITTFAM
     VSSVLAALPE ADLPDLRTII VGGEAPSREL VARYATGRQF INCYGPTETT VTATLKHCQD
     DGKNPPIGRP IANTTVYVLD AHLQPVPIGV PGELYIGGKG VARGYWNRPE LTAERFIADP
     FGQADERLYR TGDLVRYLEN GELEFLGRID DQVKIRGYRI ELGEIENALR QHPAVQNVVV
     IARQEGAGDK RLAAYLVAAT GQQPDEAELV RYLKSTLPEY MVPAGYVWLE KIPLTVNGKV
     DRRALPAPDY GHAETGKAYV APRKPIEEIV ANIWAQVLSV ERVGVYDDFF ELGGHSLLAT
     QAVSRLKEAF GVNVPLRTLF EHPDVAGMSE KLAGLLEEQS GVTSIPLVPV PRDKQLPLSF
     AQQRLWFLDR LMPDSALYNI PSAVRIQGQL NIRAWERSLQ TIIERHESLR TTFTDIGGEA
     VQVIHEMMEW RLVEIDLRDL PDEEREAAVQ RLEKAEASQP FNLRTGPLLR ATLIQTGEED
     FVFLLNMHHI VSDGWSMSIF MGELATIYEA LSKGDTPQLA EMPLQYADFA AWQRDWLQGE
     VLEQQLAYWR EKLGAAEPML ALPTDRPRPA VQTHHGALYT TAFPLALTEK LHALSRQEGA
     TLFMTLLAAF QTLLYRYSGQ DDIIVGSPVA GRNKQETESM IGFFINTLAM RTDMSGAPTF
     RELLARVRDT ALEAYTHQDL PFEKLIDELE LERSLSYSPL FQVMFALQNF QMLTREFEGI
     EIVPFESKNE AVMSKYDISL TMAETQNGLV ATFDYNTDLF DHSTIVRMVN HFHQLLEGIV
     ARPDSSIQAL PLLATDEREQ LVSAWNNTAA AYTYEQTVHE LVAAMAEKMP EQLAVVSAEG
     SLTYAQLDAK ANQLANYLQQ QGITPETLVG ICVERSSEMI VGQLGILKAG GAFVPMDPAY
     PQERLAFMMA DTGMPFVLTQ ERLLETLPAG DAAFICLDAD WEVIAEESTQ APELAVTTDQ
     LAYVIYTSGS TGTPKGVEIE HRALLNLIYW HQHAYTITPD DRASQIAGTA FDAAVWEIWP
     YMTAGATLYL PQEEIRLIPE KLRDWLVAEG ITISFLPTPL AESMLSVDWP SHAALRYVLT
     GGDKLHHYPA EHVPFTLVNQ YGPTENAVVA TAGIVAVQAG QVTPPSIGRP IDNVQVYILD
     EQRQPVPIGV TGELYIAGSS LARGYYKRPD LTQERFVDNP FTANRGAKMY RTGDLVRYLP
     DGQIEFIGRS DDQVSIRGFR VELGEIESVL YQHPAVKEAI VLAREDMPGV KRLAAYVVVA
     EDDAEQADDL RGYLKEKLPE YMVPAAFVTL KALPLTPNGK VDRRALPVPE YTAADGEYVA
     PETFVEKVLA QIWKEVLGVE EVGIHDNFFE LGGDSILSIQ IVARAGQSGI RLSPKLLFEN
     QTIAELSHAV GDSVHICAEQ GLVTGEVPLL PIQHWFFEQK LADRNHWNQS VLLTVQPIDP
     EILKQAFYHL LGHHDALRLR FYHQNGAWKQ AGAEWTDIIP FYVVELGDLP ANQQVEQIEK
     LSGEAQASLH LADGPLLRAV YFDMGAGQEG RLLIVIHHLA VDGVSWRIIT EDLNKACNQL
     LQGKQVQLPP KTSSYKYWAE KLVEYAASDS LTEEADYWLS RLDTEVAALP KDYEHGQNRE
     LAARTVSVAL TQEETKVLLQ ELPAVYQTQI NDVLLTALAE AVFVWTGNQT TLVHLEGHGR
     EDIFDDVDLS RTVGWFTSMY TILLDTRGTS SLTEALQTTK EQLRSIPHKG IGYGILRYLN
     KETAEKFKSL PKAQISFNYL GQLDQAVRDT DSLFGFASEA RGDNFNRNSD RQHLLDFGCS
     VVGGQLVVSV AFSKEIYRKE TIEALADYYI TALRQLLAHA KTDKAAAPAQ SAASNLSEFG
     WDDEEIADLL DLIQDK
//
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