ID Q70WS7_BAYMV Unreviewed; 2412 AA.
AC Q70WS7;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 113.
DE SubName: Full=Polyprotein 1 {ECO:0000313|EMBL:CAD56471.1};
GN Name=1 {ECO:0000313|EMBL:CAD56471.1};
OS Barley yellow mosaic virus (BaYMV).
OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Stelpaviricetes;
OC Patatavirales; Potyviridae; Bymovirus.
OX NCBI_TaxID=12465 {ECO:0000313|EMBL:CAD56471.1};
OH NCBI_TaxID=4513; Hordeum vulgare (Barley).
RN [1] {ECO:0000313|EMBL:CAD56471.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1 {ECO:0000313|EMBL:CAD56471.1};
RA Adams M.J.;
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAD56471.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=1 {ECO:0000313|EMBL:CAD56471.1};
RX PubMed=13679620; DOI=10.1099/vir.0.19347-0;
RA Kuehne T., Shi N., Proeseler G., Adams M., Kanyuka K.;
RT "The ability of a bymovirus to overcome the rym4-mediated resistance in
RT barley correlates with a codon change in the VPg coding region on RNA1.";
RL J. Gen. Virol. 84:2853-2859(2003).
CC -!- FUNCTION: Has RNA-binding and proteolytic activities.
CC {ECO:0000256|ARBA:ARBA00029399}.
CC -!- FUNCTION: Indispensable for virus replication.
CC {ECO:0000256|ARBA:ARBA00034080}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolyzes glutaminyl bonds, and activity is further
CC restricted by preferences for the amino acids in P6 - P1' that vary
CC with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or
CC Gly) for the enzyme from tobacco etch virus. The natural substrate is
CC the viral polyprotein, but other proteins and oligopeptides
CC containing the appropriate consensus sequence are also cleaved.;
CC EC=3.4.22.44; Evidence={ECO:0000256|ARBA:ARBA00000785};
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle
CC {ECO:0000256|ARBA:ARBA00004541}. Host cytoplasmic vesicle
CC {ECO:0000256|ARBA:ARBA00034108}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}. Virion
CC {ECO:0000256|ARBA:ARBA00004328}.
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DR EMBL; AJ515479; CAD56471.1; -; mRNA.
DR GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0044161; C:host cell cytoplasmic vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0031982; C:vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR CDD; cd23175; ps-ssRNAv_Potyviridae_RdRp; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001592; Poty_coat.
DR InterPro; IPR001730; Potyv_NIa-pro_dom.
DR InterPro; IPR013648; PP_Potyviridae.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001205; RNA-dir_pol_C.
DR InterPro; IPR007094; RNA-dir_pol_PSvirus.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF118; ATP-DEPENDENT RNA HELICASE DHX33; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00863; Peptidase_C4; 1.
DR Pfam; PF00767; Poty_coat; 1.
DR Pfam; PF08440; Poty_PP; 1.
DR Pfam; PF00680; RdRP_1; 1.
DR PRINTS; PR00966; NIAPOTYPTASE.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51436; POTYVIRUS_NIA_PRO; 1.
DR PROSITE; PS50507; RDRP_SSRNA_POS; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Capsid protein {ECO:0000256|ARBA:ARBA00022561,
KW ECO:0000313|EMBL:CAD56471.1};
KW Covalent protein-RNA linkage {ECO:0000256|ARBA:ARBA00022520};
KW Helical capsid protein {ECO:0000256|ARBA:ARBA00022497};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Host cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00022488};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022844}.
FT TRANSMEM 259..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 474..632
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1359..1574
FT /note="Peptidase C4"
FT /evidence="ECO:0000259|PROSITE:PS51436"
FT DOMAIN 1858..1982
FT /note="RdRp catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50507"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2177..2202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2412 AA; 270802 MW; 606827FE729B375B CRC64;
MEQTLAQAVS RKGKTNTPMA EERKHFSPMN FSANFVAPEL FYSANVRKIK NIFRERSTTR
FLDAISSDFE LVAFLTLSPA HLMQLETTLR QEIRSSVVPI VTSDASFETV AVIKTALDGM
RFHFGHTTLE KGWMSMMRHA ESCLQESSSS AVNDLQMQIK RVGSLLLSGK NRVESCELSV
LNLTARRFRI EYGLNGTYFG EHVAMLLDLK RYIYGTVPKE FLWAKTKKHS LFTTPEWIKR
TPIDCFLFCL RVIPILHRFG VAISLLYWSC VAALNFPAFM AFLFKRQFAK YLAHSCAKHS
IYFIFLSIIA ILWSFRTFAS QKPKIVLQAR STAEKEKKLM MILASVVGIT YLFDYDIAEA
LGNCLHKISR LSSYLLDDHQ GIASRMFGAS YGLQAGDSAE DAITTIISDL LSVTFKIVDE
DASQGTVEDA SETTFHSWVG VNTLAGRNMS RPLQYDVNKT YALTPQNVQL QARAMADANN
CWSMVVGHTG SGKSTYLPVQ YSNYLSTKSD RRQQILICEP TQAATENVCA GVAANLGRAV
YGRHEGWSRM GDHCIQVMTY GSALQCHAMD PSFISTFDAI FLDEAHDIKE HSLVFESICD
TFKSVRKFYV SATPRDGSVC PEAARKYPLH VETSVCDSYR KFIAAQGGGD LLDISKHDTA
LVFLAGRPEC IKAANAWNAS VTGEKRAFPL SSDNFATDFS MLTERLKTHK TIIFTTNIIE
TGVTLSVDCV VDFGHTMRPC LDLNQKSLRL DRRRVTRNER QQRIGRAGRL KDGYAIVCGD
VDRAVNIISP DVLYGAALLS FKHNVPFYMN ETFESSWLEG VTKAQADTMT IFKLPIFLTR
DLINADGSVA REFLDVLKRH QFTTSDIKQA PSVTAKHIFP TWASYFSLHQ ALHYGDDKDE
IPHELRYARV PFSVTTLSKF DWPALALACE KHRASMSNVF AGIEEPARVV TLQTNPANIQ
ASITHLTHMS KNYKTLIENN QHVRQSMMTN VMFKWFSSTR ITKDLDRNLR RCTDNLSVVE
ATLSSLRQIL AGNTQVHATP HMQSTLEDII ELQASDTLTE ESLANALGIF VPKCNLFLLL
ATKGFKLVYV VCILLLVNLV YTGLRKWREH LKQKGSNEIL TNTMPVSEGG EILAEVMKME
PKMRKNIKRD MDAAVESKLC GFTFVFPDDD KIGLEGKGNK YRPREDARLM YSTREDATFD
AWNEKAKERR KKVTDKAEPE LRRAYEKRPY FNFYDLQTDS NILEAIFYTT EGDEFFRTAD
PNKDMNLVAD KLRSFLDTKL VVGHHQRKLL EETAHVVVKD TKGTAHKMEI SEDDPDFLKE
NGSGKVGYPE HRGQFRQEGV AITGDYDLEA EFGADADEIT LEASTGILLS QVGVDVATRV
GRICIGTFNM NCYFYSDWIL VPGHLQDRSG NVTIQFPDQT VQTTTDALNA NGVKRFYGLD
VIAIRRPAIL RPRTKLVKAF AIEEPVIAQM VFVDAQGVRK FTQSDWARKE ENSGRWSHKI
STVLGMCGCP VLDVGKNRLI GIHVATNYTK KRNEFQPFTQ EVVDFINGPG TKIPYCPWVF
DRPACGYSSP NALFEKPTTL ADVIHMQASD GLHNINNAIE GFGSSLKGQL VSPPTESTRQ
RFDKLFGSGS FELIGQMNKG LIDKHVIVGE NDDVYDFMRE HPTFTWLKDF MNEYAPSVLS
YSAYYKDLCK YNRAKHVLTY NPEELHCATK GLIKMLEDAG LTQGSVRTPQ QVVSDIQWNT
SAGPSYQGKK RDLCAHLSDD EVLHLAEVCR QQFLEGKSTG VWNGSLKAEL RTIEKVEAEK
TRVFTASPIT SLFAMKFYVD DFNKKFYATN LKAPHTVGIN KFGRGWEKLH DKLNRPGWLH
GSGDGSRFDS SIDPFFFDVV KTIRKHFLPS EHHKAIDLIY DEILNTTICL ANGMVIRKNV
GNNSGQPSTV VDNTLVLMTA FLYAYIHKTG DRELALLNER FILVCNGDDN KFAISPQFDE
EFGHDFSPEL VELGLTYEFD DITSDICENP YMSLTMVKTP FGVGFSLPVE RIIAIMQWSK
KGGVLHSYLA GISAIYESFD TPKLFKSIYA YLLWLTEEHE AEILAAMTQS STALPIPSML
DVYRLHYGDD EIWLQAADPL TDAQKEAAHT AAADRARLDL ADADRRRKVE ADRVEAARVK
KAADAVLKPV NLTATRMPTE DDGKLKTPSG ARIPSSAADG NWSVPATKQV NAGLTLKIPL
NKLKSVPKSV MEHNNSVALE SELKAWTDAV RTSLGITTDE AWIDALIPFI GWCCNNGTSD
KHAENQVMQI DSGKGAVTEM SLSPFIVHAR MNGGLRRIMR NYSDETVLLI TNNKLVAHWS
MKHGASANAK YAFDFFVPRS WMNPQDIEVS KQARLAALGT GTYNTMLTSD TTNLRKTTNH
RVLDSDGHPE LT
//