ID Q71JD2_DROHY Unreviewed; 4488 AA.
AC Q71JD2;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 08-NOV-2023, entry version 88.
DE SubName: Full=Dynein heavy chain protein {ECO:0000313|EMBL:AAQ06635.1};
GN Name=Dhc3 {ECO:0000313|FlyBase:FBgn0025433};
OS Drosophila hydei (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7224 {ECO:0000313|EMBL:AAQ06635.1};
RN [1] {ECO:0000313|EMBL:AAQ06635.1}
RP NUCLEOTIDE SEQUENCE.
RA Reugels A., Kurek R., Schroer S., Lammermann U., Buenemann H.;
RT "Orthologous Dhc gene pairs on the heterochromatic Y chromosomes of
RT Drosophila melanogaster and Drosophila hydei mutate with a 3.5-fold higher
RT amino acid substitution rate than their autosomal homologs.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AF494076; AAQ06635.1; -; Genomic_DNA.
DR FlyBase; FBgn0025433; Dhyd\Dhc3.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1867..2003
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2471..2616
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 1572..1599
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3054..3105
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3291..3332
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3590..3624
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4488 AA; 514513 MW; DA898EF04C769979 CRC64;
MEQPSTSAEA AAAAAAGGPD PRLELMGSFV IKSLKLKPEK WTRVITVEEH KGIIKEFLDR
NTPVVLIIIL TPAAQLVPST TFPLSQLKSK GVYFIKRYAQ PIPRENCGNF IISGDLATRT
IDQLSALVEE VLVPLLSNED NYRSWPIMVA QDVQKHVTRL KSTVHQVKGQ VSGETILAMP
VGVEKIVKAA KELTETQHCQ FDLYLKSAIE GVVIKWATQI HEVIKESPTN AFANGQNPTP
HTEFTFWNNR LKNLSFIYDQ LRNERIRAMA LILEYSLSAY HPCFQTLFKN VVTALAEAKD
ITLYLNPLKR PLHQLEEIDF AEFKPLLIPF MHTVCTLWGN SRYYCQSAKI TVLLQEICNL
IIHQAKRYLD PSSIFHSDID EAMQRLTLSI QILKFFRELF DYYKDRLAAF FTEPEERPPI
LWTFHPNSVF KRFNAFLERL TTIQWFFFTV IEFLKLEKVE IGGLRGRQLS TRITDVYVEF
NQYFTAFASK SYDVLDPDDH EFDEDFKGFQ TRILELDMKL AAILCQAFDD CHNLESIFKL
ISIVGSVLDR PKIKEEFTQR YAEIVRMLDD EMTVCENIFD KQMELRRNGD TLYPDYNCPS
VAAFIRWCYQ LETRITGPIK NFKALQHDIT KTEKSVEILE RYECLMAKLG ACKTQFFEEW
SVQLAAQIEE DLRKSLIARD QHSHSLILNF SSTLFSILRE VHYMQQMKID GIPEIAIEFA
EKSDVFRSYT LNLEKTIDWY NSIQEGSSPV ELKLIEPEIK MIDDLVEIGV DQLVWNSTDI
MSYLEKLRQQ VAALRNRMNH TQHNLRQVRK IMEVWAKQPL FERRDCKKDS VLSIDERPDR
TAKRYAEIQA ASAEIHKLLQ DNMLQFGMAD KQNDAVWLSY VDFVDNILYE NILRTVGVSV
GYLAENMDPD NNYAPLFESR LELVEPNMVF VPSLEPDDPM GFNNMLIELM RDIMKMGSLI
KRLKPNEKRN YVELIKENQD IIDMRREILN GVDLVMEEAS RFCRQFERYS YLWLDDREEC
MEYFLEYGRM LDPDEIELLQ MNDPAAPPPP QPCQPTIEAF REQIDNYESL FTEIEDIPAF
QVFSSRFQVD VRPFRQALLN TVCKWGNMFK MHLVTTVTSS LMDLSHFIRR ADEGLLQTVK
EKDYEGLVSI MAYLMQVKER AANTDEMFEP MQETITGFLK YYDMDIPEEV NVLLQELPEQ
WANTKKIATT VKQQVSPLQA TRGVSIRHKI TLFEAHIQLF REVFKQYDFF RFDCVKPYLL
MDRINDDMYL CEREMGEIQK SGSLFEVNIP EFKVLRQCRK ELRMLKQLWD YVNIVQTSIE
DWKTTPWAKV DVENMDIECK KFAKDIRLLD KEMRVWDTFI NLESTVKNML TSLRAVGELQ
NPAIRERHWN QLMNSTKVKF IMDHETTLAE LLGLNLHECE EEVKNIVDKA VKEMSMEKIL
RDLNSTWSAM EFDNELHPRT GCKLLKASEE LIETLEENQV CLQNLITSKY IAHFLEEVST
WQNKLMIADS VITVWFEVQR HWTHLESIFM SSEDIRKQLP VDSVRFDNID AEFRYLMDEM
SVSSNVVAST NRAGLIERLE HLQKELTLWQ KALAEYLETK RLAFPRFYFV STADLLDVLS
NGIQPDMVTK HLTKLFDSIA RLKFNRDAAN EIETASGMYA KDGEYVEFNE LASIRGPVEV
WLNRIQAAMR ASLRHYVTEA VVAYEEKQRE QWLFDYPAQV SLCGSQIWWS TEVNIAFSRL
EEGYDNAIKD YYKKQISQLS LLITLLLGEL TKGDRQKIMT ICTIDVHSRD VVAKMIQAKL
DSGSAFMWQS QLRHRFDDVE KDCFANICDA EFQYCHEYLG NTPRLVITPL TDRCYITLTQ
SLHLVMGGGP AGPAGTGKTE TTKDLGRAIG IMVYVFNCSE QMDYQSCGNI YKGLAQTGAW
GCFDEFNRIT VEVLSVVAVQ VKSVQDAIRD KKDTFNFMGE IISCVPTVGI FITMNPGYAG
RTELPENLKA LFRPCAMVVP DFELICEIML VAEGFQDARV LARKFITLYT LCKELLSKQD
HYDWGLRAIK SVLVVAGSLK RGDGGRPEEE VLMRALHFNI PKIITDDMPV FMGLISDLFP
ALDVPRKRVQ DFERTVKQAA SDLLLQPEDN FILKVVQLEE LLEVRHSVFI VGNAGTGKTQ
VWKTLLRTYQ NIKRKPIFND LNPKAVTNDE LFGIINPATR EWKDGLFSVL MRDQANITGD
QPKWIVLDGD IDPMWIESLN TVMDDNKVLT LASNERIALT PSMRLLFEIS NLRTATPATV
SRAGILYINP QDLGWNPHVT SWVETRKIPA EKSNLVMLFD KYIPSSLDTI RVRFKKITPV
AEMAHIQMLC HLLNCFIIPA NTPADCPKEW HELYFVFACI WAFGSAMFQD QAIDYRVEFS
KWWVNEFKTV KFHRCGTVFD YFLDSETKTF LPWTEKITKF ELDSDLPLQA VLVHTSESIR
LRYFLDLLMD KKHPVMLVGN AGCGKTVLVN EKLQSLSENY AVTTIPFNYY TTSEMLQKIL
EKPLEKKAGR NYGPPGNKTL IYFVDDINMP EVDCYGTVQP HTLMRQHLDY GHWYDRNKLT
LKDIHNCQYV ACMNPTSGSF TINPRLQRHF CVLAVSFPGT DSITVMYSAI LSQHFANAEQ
KFIPIVTRMT FNIVAATIAL HNKCLQVFLP TAIKSHYIFN LRDISNVFQG LLFSSTDCLT
SSTDLIRLWQ HETQRVYSDK LIDDKDIDSF TKMQHDIVKK SFEEIDESVI FDKPNIYCHF
ACICGGIGDP KYMPIKGWPE LHKLLQEAMS SYNDLVAAMN LVLFEDAMMH VCRINRILES
PRGSALLVGV GGSGKQYIAR LAAFISSLEV VQIQLKKGYG VNDLKNEFSG LYLKAGLKNV
MFLMTDAQIP SEDFLVLIND LLATGEIPDL FPDDEIENII AGVRNEVKGA GLVDTRENCW
KFFIDRVRKQ LKIVLCFSPV GSTLRVRSRK FPAIINATSI NWFHEWPQEA LISVAMNFLA
QNKVLPDNHR DSVAKFMAYV HTSVNTTSKV YLQNERRYNY TTPKSYLEQI NLYLKLLNHK
HEDLQSKIER LENGLEKLRS TAVQVADLKV KLAVQEVELK EKNDAADALI EIVGIETEKV
QTEKAVADEE EMKVALIADE VSKKQRDCEE DLLKAEPALL AAQEALNTLN KANLTELKSF
GSPPGAVTNV TAAVMVLLAP GGKLPKDRSW KAAKISMAKV DAFLDALINY DKENIHPEII
KAIQPYVKDP EFEPEFVRSK SGAAAGLCAW VINIIKFYEV YCDVEPKRKA LAAANAELAA
AQDKLAGIKR KVASLEEQMA KLTADFEKAI ADKLRCQQEA DATQATIALA NRLVGGLASE
NVRWAEAVNN FVKQGITLPG DILLITAFIS YVGCFTKGFR IDLLQKMWTP FLKSIDPPIP
TTENLDPLTL LTDDTTIAIW TNEGLPSDRM SIENATILSN SDRWPLMIDP QLQGVKWIKR
KYGDQLKVIR FGQRNYLDII EKSINTGITV LIENIDENLD PVLDSLLGRN LIKKGKAIKI
GDKEIEYNST FRLILHTKLA NPHYKPEMQA QTTLINFTVT RDGLEDQLLA EVVKAERPDL
EDLKAELTKQ QNDFKIMLKK LEDDLLSRLS SAGENILGDT ALVENLETTK STASDIEEKV
AEAKITSKEI DKAREYYRPA AARASLLYFI LNELNTINPI YQFSLKAFSV VFQKAIAKAE
PSETLALRVS NLIDCITYSV FQYTSRGLFE CDKLIFASQM TFQILLMNEE LSSAELDFLL
RFPIKPHVTS SVDFLSNQSW GGICSLASKD EFRNLDRDIE TSSKRWKKLV ESELPEKEKF
PQEWKNKTAL QRLCMIRALR PDRMTYALAD FIEEKLGSKY VESRAMEFAK SYEEASPSTP
IFFILSPGVN PLIDVEALGK QMGFSMDLNN FHNVSLGQGQ ESIAETAMDT AAKNGHWVVL
QNIHLVRKWL PVLEKKLEHY AEGSHPDYRM FLSAEPASTP SAHIIPQGIL ESSIKITNEP
PTGMLANLHK ALDNFTQETL EMSGKEAEFK AILFSLCYFH AVVAERRKFG AQGWNKIYPF
NVGDLNISVS VLYNYLEANA KVPWEDLRYL FGEIMYGGHI TDDWDRRLCI TYLEEYMQPD
LVDGELFLAP SFAAPPNTDY LGYHNYVDDM MPAESPYLYG LHPNAEVGFL TTRAENIFRT
VFEMQPRDAG AGGGATVTRE DKVKQIVDEI IEKLPEEFNM VEIMNKVEER TPYVIVAFQE
CERMNFLTSE MKRSLKELDL GLKGELTITS DMEVLENSLF LDQVPPIWTQ RAYPSLLGLN
NWFIDLCLRL RELETWSTDF VLPSCVWLAG FFNPQSLLTA IMQSTARRNE LPLDKMCLQC
DVTKKQKEEF TTAPRDGCCV HGIYMEGARW DIQQGIIMES RLKELYPSMP VINIRAITQD
KQDLRNMYES PVYKTRTRGP TYVWTFNLKT KDKQGKWTLA GLALLLQT
//
