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Database: UniProt
Entry: Q721J2
LinkDB: Q721J2
Original site: Q721J2 
ID   DLTA_LISMF              Reviewed;         510 AA.
AC   Q721J2;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-SEP-2014, entry version 67.
DE   RecName: Full=D-alanine--poly(phosphoribitol) ligase subunit 1;
DE            EC=6.1.1.13;
DE   AltName: Full=D-alanine-D-alanyl carrier protein ligase;
DE            Short=DCL;
DE   AltName: Full=D-alanine-activating enzyme;
DE            Short=DAE;
GN   Name=dltA; OrderedLocusNames=LMOf2365_0994;
OS   Listeria monocytogenes serotype 4b (strain F2365).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=265669;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F2365;
RX   PubMed=15115801; DOI=10.1093/nar/gkh562;
RA   Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T.,
RA   Kolonay J.F., Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T.,
RA   Peterson J.D., White O., Nelson W.C., Nierman W.C., Beanan M.J.,
RA   Brinkac L.M., Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R.,
RA   Haft D.H., Selengut J., Van Aken S.E., Khouri H.M., Fedorova N.,
RA   Forberger H.A., Tran B., Kathariou S., Wonderling L.D., Uhlich G.A.,
RA   Bayles D.O., Luchansky J.B., Fraser C.M.;
RT   "Whole genome comparisons of serotype 4b and 1/2a strains of the food-
RT   borne pathogen Listeria monocytogenes reveal new insights into the
RT   core genome components of this species.";
RL   Nucleic Acids Res. 32:2386-2395(2004).
CC   -!- FUNCTION: Involved in the biosynthesis of D-alanyl-lipoteichoic
CC       acid (LTA). Catalyzes an ATP-dependent two-step reaction where it
CC       forms a high energy D-alanyl AMP intermediate and transfers the
CC       alanyl residues from AMP to Dcp (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + D-alanine + poly(ribitol phosphate) =
CC       AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate).
CC   -!- PATHWAY: Cell wall biogenesis; lipoteichoic acid biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme
CC       family. DltA subfamily.
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DR   EMBL; AE017262; AAT03772.1; -; Genomic_DNA.
DR   RefSeq; YP_013595.1; NC_002973.6.
DR   ProteinModelPortal; Q721J2; -.
DR   STRING; 265669.LMOf2365_0994; -.
DR   EnsemblBacteria; AAT03772; AAT03772; LMOf2365_0994.
DR   GeneID; 2799331; -.
DR   KEGG; lmf:LMOf2365_0994; -.
DR   PATRIC; 20323214; VBILisMon105049_0997.
DR   eggNOG; COG1020; -.
DR   HOGENOM; HOG000229995; -.
DR   KO; K03367; -.
DR   OMA; NHDFEKE; -.
DR   OrthoDB; EOG6QP0WP; -.
DR   UniPathway; UPA00556; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0047473; F:D-alanine-poly(phosphoribitol) ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070395; P:lipoteichoic acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00593; DltA; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig.
DR   InterPro; IPR010072; DltA.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   TIGRFAMs; TIGR01733; AA-adenyl-dom; 1.
DR   TIGRFAMs; TIGR01734; D-ala-DACP-lig; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding.
FT   CHAIN         1    510       D-alanine--poly(phosphoribitol) ligase
FT                                subunit 1.
FT                                /FTId=PRO_0000213147.
SQ   SEQUENCE   510 AA;  57613 MW;  8AE9326D9D3A8FE5 CRC64;
     MTTSIIERID AWAEKTPDFP CYEYAGTRLS YKELKRQSDA FGSFLLKNLN TDKEKPIIVY
     GHMSPLMLVA FLGSIKSGRA YVPVDVSMPV ERIEQIKKAA DPSLFICTEE LPSNLTITGC
     PVLTQDQLMD ALEKHFGEVP DKEACVKNDD NYYIIYTSGS TGNPKGVQIS QNNLVSFSNW
     ILQDFSLSQG LRFLNQAPFS FDLSVMDLYP SLLSGGTLVP LDKTITANMK DLYREIPAQN
     LDVWVSTPSF ADLCLLDDNF NQENNPGLIR FLFCGEVLAK KTASELLNRF PDAVIYNTYG
     PTEATVAVTQ VKVTREVIDA YPSLPLGVIK PDMRLHIVDQ ETGEVLPEGE KGEIVLIGAS
     VSKGYLNEPE KTDQVFFDYK GYQAYRTGDS GIIKDGYLFF QGRLDFQIKL HGYRIELEDI
     ENNLKKVSYI QNCAIIPKMK DEKVDMLVAQ VIPTNHDFEK EYQLSAAIKN ELKEFMPAYM
     IPRKWIYKTE FPLTMNGKID RKALNSEVNK
//
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