ID Q726U0_DESVH Unreviewed; 481 AA.
AC Q726U0;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE SubName: Full=B12 binding domain protein/radical SAM domain protein {ECO:0000313|EMBL:AAS97487.1};
GN OrderedLocusNames=DVU_3016 {ECO:0000313|EMBL:AAS97487.1};
OS Desulfovibrio vulgaris (strain ATCC 29579 / DSM 644 / NCIMB 8303 / VKM
OS B-1760 / Hildenborough).
OC Bacteria; Thermodesulfobacteriota; Desulfovibrionia; Desulfovibrionales;
OC Desulfovibrionaceae; Nitratidesulfovibrio.
OX NCBI_TaxID=882 {ECO:0000313|EMBL:AAS97487.1, ECO:0000313|Proteomes:UP000002194};
RN [1] {ECO:0000313|EMBL:AAS97487.1, ECO:0000313|Proteomes:UP000002194}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29579 / DSM 644 / NCIMB 8303 / VKM B-1760 / Hildenborough
RC {ECO:0000313|Proteomes:UP000002194};
RX PubMed=15077118; DOI=10.1038/nbt959;
RA Heidelberg J.F., Seshadri R., Haveman S.A., Hemme C.L., Paulsen I.T.,
RA Kolonay J.F., Eisen J.A., Ward N., Methe B., Brinkac L.M., Daugherty S.C.,
RA Deboy R.T., Dodson R.J., Durkin A.S., Madupu R., Nelson W.C.,
RA Sullivan S.A., Fouts D., Haft D.H., Selengut J., Peterson J.D.,
RA Davidsen T.M., Zafar N., Zhou L., Radune D., Dimitrov G., Hance M.,
RA Tran K., Khouri H., Gill J., Utterback T.R., Feldblyum T.V., Wall J.D.,
RA Voordouw G., Fraser C.M.;
RT "The genome sequence of the anaerobic, sulfate-reducing bacterium
RT Desulfovibrio vulgaris Hildenborough.";
RL Nat. Biotechnol. 22:554-559(2004).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; AE017285; AAS97487.1; -; Genomic_DNA.
DR RefSeq; WP_010940275.1; NC_002937.3.
DR RefSeq; YP_012227.1; NC_002937.3.
DR AlphaFoldDB; Q726U0; -.
DR SMR; Q726U0; -.
DR STRING; 882.DVU_3016; -.
DR PaxDb; 882-DVU_3016; -.
DR DNASU; 2793729; -.
DR EnsemblBacteria; AAS97487; AAS97487; DVU_3016.
DR KEGG; dvu:DVU_3016; -.
DR PATRIC; fig|882.5.peg.2734; -.
DR eggNOG; COG1032; Bacteria.
DR HOGENOM; CLU_021572_4_6_7; -.
DR OrthoDB; 9804952at2; -.
DR PhylomeDB; Q726U0; -.
DR Proteomes; UP000002194; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409:SF7; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Reference proteome {ECO:0000313|Proteomes:UP000002194}.
FT DOMAIN 1..127
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 166..395
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 481 AA; 54075 MW; 5A4FF907A7CBB263 CRC64;
MRFMFLHPRL SLEGDPLGLM QLSASLKQRG HIVGLTLLTE DYIEAIRSFQ PDMLGVSLMS
SDAVMMHQVL NKVRMVFPDL FIIVGGPHPT FDPSCLMVLP VNAICVGEGD EALVEALEQY
GREGHVEGIR NVGTVTTPVT LRPLVSDLDD LPFIDRDIVY AKNHIVRDFP LKTFAASRGC
HFKCTYCFNH AYNAMYAGLG HVVRRRSVDH LIAEMRDVIA RYPTSYIKIS DDSFTYRVDS
WLEEFAEKYP RLIGLPFYCL LRADVVTRDM VRLLREAGCR SVCMSIEAGA ETVRRDVLNR
RVSNEKIIES FDLFNEAGIA IYTNSMLAMP RATLADDIAT LDLNIRCRPT LGHFTIMAPF
PGTRIHDMCE KDGILPERCG GDGDIPTSTG ELSKLTTYTD EEKNIQKNIV LLGPLVIRFP
VLRGVFLRCL AKLPSNNILF KCIYTVTKNL LFKRIVPVRM SPLLMLRIAI AQVKAARTQV
G
//
