ID Q72T32_LEPIC Unreviewed; 660 AA.
AC Q72T32;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=HD-GYP domain-containing protein {ECO:0000259|PROSITE:PS51832};
GN OrderedLocusNames=LIC_11189 {ECO:0000313|EMBL:AAS69796.1};
OS Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni
OS (strain Fiocruz L1-130).
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=267671 {ECO:0000313|EMBL:AAS69796.1, ECO:0000313|Proteomes:UP000007037};
RN [1] {ECO:0000313|EMBL:AAS69796.1, ECO:0000313|Proteomes:UP000007037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fiocruz L1-130 {ECO:0000313|EMBL:AAS69796.1,
RC ECO:0000313|Proteomes:UP000007037};
RX PubMed=15028702; DOI=10.1128/JB.186.7.2164-2172.2004;
RA Nascimento A.L., Ko A.I., Martins E.A., Monteiro-Vitorello C.B., Ho P.L.,
RA Haake D.A., Verjovski-Almeida S., Hartskeerl R.A., Marques M.V.,
RA Oliveira M.C., Menck C.F., Leite L.C., Carrer H., Coutinho L.L.,
RA Degrave W.M., Dellagostin O.A., El-Dorry H., Ferro E.S., Ferro M.I.,
RA Furlan L.R., Gamberini M., Giglioti E.A., Goes-Neto A., Goldman G.H.,
RA Goldman M.H., Harakava R., Jeronimo S.M., Junqueira-De-Azevedo I.L.,
RA Kimura E.T., Kuramae E.E., Lemos E.G., Lemos M.V., Marino C.L., Nunes L.R.,
RA De Oliveira R.C., Pereira G.G., Reis M.S., Schriefer A., Siqueira W.J.,
RA Sommer P., Tsai S.M., Simpson A.J., Ferro J.A., Camargo L.E.,
RA Kitajima J.P., Setubal J.C., Van Sluys M.A.;
RT "Comparative genomics of two Leptospira interrogans serovars reveals novel
RT insights into physiology and pathogenesis.";
RL J. Bacteriol. 186:2164-2172(2004).
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DR EMBL; AE016823; AAS69796.1; -; Genomic_DNA.
DR RefSeq; WP_000802798.1; NC_005823.1.
DR AlphaFoldDB; Q72T32; -.
DR GeneID; 61144508; -.
DR KEGG; lic:LIC_11189; -.
DR HOGENOM; CLU_000445_92_13_12; -.
DR Proteomes; UP000007037; Chromosome I.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 2.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR037522; HD_GYP_dom.
DR PANTHER; PTHR43155:SF2; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108; 1.
DR PANTHER; PTHR43155; CYCLIC DI-GMP PHOSPHODIESTERASE PA4108-RELATED; 1.
DR Pfam; PF01590; GAF; 1.
DR Pfam; PF13487; HD_5; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 2.
DR PROSITE; PS51832; HD_GYP; 1.
PE 4: Predicted;
FT DOMAIN 334..660
FT /note="HD-GYP"
FT /evidence="ECO:0000259|PROSITE:PS51832"
SQ SEQUENCE 660 AA; 76108 MW; EF1A5387F432F4F6 CRC64;
MKPKFPKYIV TDLDSIVKRL GPIISRLEIE FLDFKEFFQS ELFRNSSGFL NVIFYLTVSD
LKKTQKEIHQ QFQRNPLILS RFILNENLDY VHSEDLKIEE ELIFSVLPES SSDMVFNKTF
LNAFTQLQMI TDQFDLQHKV NTTKYEISKL TRVGISLADE KDINKLLREI IFSAREIAIA
DSGSLYLVEK DELGLVRNLR FKISSMDIDT EEFLLPINKS SVAGYVAATG KILNIPDVYN
LPEDSEYKFN RNFDVLSNYH TKSMLVVPMK NHRNEVVGVI QLINKKRNFN QKLTLEQMRG
NDVFPFDDYS AQLVMGVAGQ AAVAIQNNHL LQEIEALFEG FVTASVNAIE SRDPTTSGHS
FRVAVLTVGL AETVDLIREG KYKNTKFSKE QIKEIRYASL LHDFGKVGVR EKVLVKSKKL
EDYELELIRW RFEYIKKDIE SRILQKKTDY LKKHGAVGFA DYETSLEFEL KVEYQKLDQM
FQIVVDSNEP SILEESNFQK LEEIAKVNYS TTGGEKLSLI SPYEFGFLTI KKGSLDFAER
KEIESHVEHT FQFLSKIPWT GDLKMVPSIA HAHHEKLDGT GYPRGLTADS IPIQSKIMAI
SDIFDALTDK DRPYKRAVPI ERALDILQME ARENHVDQDL LKIFIEGKVY DKLYYSGYLR
//
