ID Q72V87_LEPIC Unreviewed; 485 AA.
AC Q72V87;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=Alcohol dehydrogenase-like N-terminal domain-containing protein {ECO:0000259|Pfam:PF08240};
GN OrderedLocusNames=LIC_10414 {ECO:0000313|EMBL:AAS69037.1};
OS Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni
OS (strain Fiocruz L1-130).
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=267671 {ECO:0000313|EMBL:AAS69037.1, ECO:0000313|Proteomes:UP000007037};
RN [1] {ECO:0000313|EMBL:AAS69037.1, ECO:0000313|Proteomes:UP000007037}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Fiocruz L1-130 {ECO:0000313|EMBL:AAS69037.1,
RC ECO:0000313|Proteomes:UP000007037};
RX PubMed=15028702; DOI=10.1128/JB.186.7.2164-2172.2004;
RA Nascimento A.L., Ko A.I., Martins E.A., Monteiro-Vitorello C.B., Ho P.L.,
RA Haake D.A., Verjovski-Almeida S., Hartskeerl R.A., Marques M.V.,
RA Oliveira M.C., Menck C.F., Leite L.C., Carrer H., Coutinho L.L.,
RA Degrave W.M., Dellagostin O.A., El-Dorry H., Ferro E.S., Ferro M.I.,
RA Furlan L.R., Gamberini M., Giglioti E.A., Goes-Neto A., Goldman G.H.,
RA Goldman M.H., Harakava R., Jeronimo S.M., Junqueira-De-Azevedo I.L.,
RA Kimura E.T., Kuramae E.E., Lemos E.G., Lemos M.V., Marino C.L., Nunes L.R.,
RA De Oliveira R.C., Pereira G.G., Reis M.S., Schriefer A., Siqueira W.J.,
RA Sommer P., Tsai S.M., Simpson A.J., Ferro J.A., Camargo L.E.,
RA Kitajima J.P., Setubal J.C., Van Sluys M.A.;
RT "Comparative genomics of two Leptospira interrogans serovars reveals novel
RT insights into physiology and pathogenesis.";
RL J. Bacteriol. 186:2164-2172(2004).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR EMBL; AE016823; AAS69037.1; -; Genomic_DNA.
DR AlphaFoldDB; Q72V87; -.
DR KEGG; lic:LIC_10414; -.
DR HOGENOM; CLU_568365_0_0_12; -.
DR Proteomes; UP000007037; Chromosome I.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43350; NAD-DEPENDENT ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR43350:SF19; RIBULOSE-5-PHOSPHATE REDUCTASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
FT DOMAIN 61..161
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
SQ SEQUENCE 485 AA; 54683 MW; F362F5299676AE57 CRC64;
MKIWNERKGK QNMKIEFSAM DYRSDETFEK ANYLFKGSLE KGWEIYRNGK EYLCLGPGYK
LLRTKLCGVC STDLSRSFLP FPLPQVIGHE VIAEDMESIH GLKQKYVVEI NDTFEARGEK
PFDKFCEEGI ASHSPTRKVL GIDRLPGGFG PYILAPQNAA ISYHTLSDKV AVLIEPFAAS
LQAVLSSPPK DGDEVAVLGP RRLGSLVVAA LAAFRNSSGT RFKISALSRR DHLLKLSFKL
GADQMIDLGK EKIETLDKRY TIVYDTTGTT SGFESAIRLT SRELHLKTTN GQEVFGIKKL
TELVVDELSL LKFADENLNF CWEKENRSNR TVYVAPNVGK VTLPSHFKVY YGKIEDAEKI
LSTEDFRGRI PRFDLGIAGT VEEIDRLIRP SRSHENSLIR PRGAILFQGK SEKNYILEFL
NSGKSIRSSR CGDFQLAIKL LQENKKISEA LEKNMVTHFY SPEDLNQAFK TAKSSESIKV
VIKHF
//
