ID Q73H15_WOLPM Unreviewed; 446 AA.
AC Q73H15;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=Protease, insulinase family {ECO:0000313|EMBL:AAS14451.1};
GN OrderedLocusNames=WD_0761 {ECO:0000313|EMBL:AAS14451.1};
OS Wolbachia pipientis wMel.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rickettsiales;
OC Anaplasmataceae; Wolbachieae; Wolbachia.
OX NCBI_TaxID=163164 {ECO:0000313|EMBL:AAS14451.1, ECO:0000313|Proteomes:UP000008215};
RN [1] {ECO:0000313|EMBL:AAS14451.1, ECO:0000313|Proteomes:UP000008215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WMel {ECO:0000313|EMBL:AAS14451.1};
RX PubMed=15024419; DOI=10.1371/journal.pbio.0020069;
RA Wu M., Sun L.V., Vamathevan J., Riegler M., Deboy R., Brownlie J.C.,
RA McGraw E.A., Martin W., Esser C., Ahmadinejad N., Wiegand C., Madupu R.,
RA Beanan M.J., Brinkac L.M., Daugherty S.C., Durkin A.S., Kolonay J.F.,
RA Nelson W.C., Mohamoud Y., Lee P., Berry K., Young M.B., Utterback T.,
RA Weidman J., Nierman W.C., Paulsen I.T., Nelson K.E., Tettelin H.,
RA O'Neill S.L., Eisen J.A.;
RT "Phylogenomics of the reproductive parasite Wolbachia pipientis wMel: a
RT streamlined genome overrun by mobile genetic elements.";
RL PLoS Biol. 2:327-341(2004).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261}.
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DR EMBL; AE017196; AAS14451.1; -; Genomic_DNA.
DR RefSeq; WP_010082492.1; NZ_OX384529.1.
DR AlphaFoldDB; Q73H15; -.
DR EnsemblBacteria; AAS14451; AAS14451; WD_0761.
DR GeneID; 70036242; -.
DR KEGG; wol:WD_0761; -.
DR eggNOG; COG0612; Bacteria.
DR Proteomes; UP000008215; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR PANTHER; PTHR43690:SF17; PROTEIN YHJJ; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:AAS14451.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 44..184
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 194..370
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 446 AA; 50570 MW; 8D728559A20A65C8 CRC64;
MLHKFFSFLI LPVLFFTYPI SSNALNIEHN IKYTKLSNGL DVYVVSNHRI PAVLHAVIYK
VGGMDDPIGK AGLAHYFEHL MFETTGKFTD IEATMSSIGA QFNAFTTKEY TCYFELIPKK
DLPLAMEVEA DRMGSFNVTQ DKIDREKNIV LEERKMRFDN QPHNLLWEEM DSAFYRTGYG
RSVIGWESDI KTYNLDDITR FHDNYYHSGN AILLIVGDVE LDEVVKLAEE KYGEIKAKPV
MRNYPNQDPV HNAGLSVTLE STEVKESVLY FRYRVPLFDH INEASAAHLA VDILGGGKSS
KLYKDLVLDK DVAVSVFAYY NSLAFSDGYI DIMIIPKSGA NLDIVERELD NAINGFVSKG
VTSEELQSSK YRYKAAQFDN LSDLTHIAMF YVPHLALGIP LDEIDISYSK INDVNLEDVN
NKIRAIFSAN KLIGRLLPKG DNNENK
//
