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Database: UniProt
Entry: Q73PH0_TREDE
LinkDB: Q73PH0_TREDE
Original site: Q73PH0_TREDE 
ID   Q73PH0_TREDE            Unreviewed;       430 AA.
AC   Q73PH0;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   25-OCT-2017, entry version 79.
DE   RecName: Full=M18 family aminopeptidase {ECO:0000256|RuleBase:RU004387};
DE            EC=3.4.11.- {ECO:0000256|RuleBase:RU004387};
GN   OrderedLocusNames=TDE_0829 {ECO:0000313|EMBL:AAS11320.1};
OS   Treponema denticola (strain ATCC 35405 / CIP 103919 / DSM 14222).
OC   Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema.
OX   NCBI_TaxID=243275 {ECO:0000313|EMBL:AAS11320.1, ECO:0000313|Proteomes:UP000008212};
RN   [1] {ECO:0000313|EMBL:AAS11320.1, ECO:0000313|Proteomes:UP000008212}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35405 / CIP 103919 / DSM 14222
RC   {ECO:0000313|Proteomes:UP000008212};
RX   PubMed=15064399; DOI=10.1073/pnas.0307639101;
RA   Seshadri R., Myers G.S., Tettelin H., Eisen J.A., Heidelberg J.F.,
RA   Dodson R.J., Davidsen T.M., DeBoy R.T., Fouts D.E., Haft D.H.,
RA   Selengut J., Ren Q., Brinkac L.M., Madupu R., Kolonay J., Durkin S.A.,
RA   Daugherty S.C., Shetty J., Shvartsbeyn A., Gebregeorgis E., Geer K.,
RA   Tsegaye G., Malek J., Ayodeji B., Shatsman S., McLeod M.P., Smajs D.,
RA   Howell J.K., Pal S., Amin A., Vashisth P., McNeill T.Z., Xiang Q.,
RA   Sodergren E., Baca E., Weinstock G.M., Norris S.J., Fraser C.M.,
RA   Paulsen I.T.;
RT   "Comparison of the genome of the oral pathogen Treponema denticola
RT   with other spirochete genomes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:5646-5651(2004).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU004387};
CC   -!- SIMILARITY: Belongs to the peptidase M18 family.
CC       {ECO:0000256|RuleBase:RU004386}.
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DR   EMBL; AE017226; AAS11320.1; -; Genomic_DNA.
DR   RefSeq; NP_971439.1; NC_002967.9.
DR   RefSeq; WP_002682090.1; NC_002967.9.
DR   ProteinModelPortal; Q73PH0; -.
DR   STRING; 243275.TDE0829; -.
DR   MEROPS; M18.002; -.
DR   EnsemblBacteria; AAS11320; AAS11320; TDE_0829.
DR   GeneID; 2739513; -.
DR   KEGG; tde:TDE0829; -.
DR   PATRIC; fig|243275.7.peg.798; -.
DR   eggNOG; ENOG4105DFM; Bacteria.
DR   eggNOG; COG1362; LUCA.
DR   KO; K01267; -.
DR   OMA; CFDHEEI; -.
DR   OrthoDB; POG091H01I4; -.
DR   Proteomes; UP000008212; Chromosome.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR001948; Peptidase_M18.
DR   InterPro; IPR023367; Peptidase_M42_dom2.
DR   Pfam; PF02127; Peptidase_M18; 1.
DR   PRINTS; PR00932; AMINO1PTASE.
DR   SUPFAM; SSF101821; SSF101821; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|RuleBase:RU004386,
KW   ECO:0000313|EMBL:AAS11320.1};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008212};
KW   Hydrolase {ECO:0000256|RuleBase:RU004386};
KW   Metal-binding {ECO:0000256|RuleBase:RU004386};
KW   Metalloprotease {ECO:0000256|RuleBase:RU004386};
KW   Protease {ECO:0000256|RuleBase:RU004386};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008212};
KW   Zinc {ECO:0000256|RuleBase:RU004386}.
SQ   SEQUENCE   430 AA;  47280 MW;  BB67FEB839C4F3E5 CRC64;
     MKKAEALMKF IDKSPSVYHA IKNAGEFLEA KGFVHLNRED TFELKPQGRY FVTNNGSALI
     AWQMPKSGNA ENGFRIVGSH SDSPTFRIKP NPEIKVNNHY LKLNTEGYGG VILSTWFDRP
     LSAAGRVIIK TGDLLKPEVK LINFDKNLLT IPSLAIHMNR EINDGYKFNK QKDTLPLIAL
     INEKLEEKGF LMNLIAEEAG VTVDKILDFD LYLYDRQPGC FIGANDEFFS VGRIDNLGMA
     CASIDALGDA LPSNFVQVAA IFDNEEVGSR TAQGAGSPFL HDTLQRIIVS TSKGNAFEEL
     QKALAKSFLI SADQAHALHP NYTEKNDITN FPLMNKGPAI KVAASMSYTT DGISAAIFRD
     ICARAKVPCQ NFVNRSDMAG GSTIGPISVS NLNIKSVDIG NPILGMHSVR ELGGTEDQEY
     ITKAFAEFYK
//
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