ID UBIE_MYCPA Reviewed; 230 AA.
AC Q73SL8;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 2.
DT 29-MAY-2013, entry version 62.
DE RecName: Full=Demethylmenaquinone methyltransferase;
DE EC=2.1.1.163;
DE AltName: Full=Menaquinone biosynthesis methyltransferase ubiE;
GN Name=ubiE; OrderedLocusNames=MAP_4055;
OS Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC Mycobacterium avium complex (MAC).
OX NCBI_TaxID=262316;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-968 / K-10;
RX PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D.,
RA Banerji N., Kanjilal S., Kapur V.;
RT "The complete genome sequence of Mycobacterium avium subspecies
RT paratuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC -!- FUNCTION: Methyltransferase required for the conversion of
CC demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity).
CC -!- CATALYTIC ACTIVITY: A demethylmenaquinone + S-adenosyl-L-
CC methionine = a menaquinol + S-adenosyl-L-homocysteine.
CC -!- PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis;
CC menaquinone-2 from chorismate: step 8/8.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. UbiE
CC family.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAS06605.1; Type=Erroneous initiation;
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DR EMBL; AE016958; AAS06605.1; ALT_INIT; Genomic_DNA.
DR RefSeq; NP_962989.2; NC_002944.2.
DR ProteinModelPortal; Q73SL8; -.
DR STRING; 262316.MAP4055; -.
DR EnsemblBacteria; AAS06605; AAS06605; MAP_4055.
DR GeneID; 2718963; -.
DR KEGG; mpa:MAP4055; -.
DR PATRIC; 18001023; VBIMycAvi108102_4317.
DR eggNOG; COG2226; -.
DR KO; K03183; -.
DR OMA; PYQYLVE; -.
DR ProtClustDB; PRK00216; -.
DR BioCyc; MAVI262316:GCQR-4100-MONOMER; -.
DR UniPathway; UPA00079; UER00169.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_01813; UbiE_methyltran; 1; -.
DR InterPro; IPR004033; UbiE/COQ5_MeTrFase.
DR InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR PANTHER; PTHR10108:SF24; PTHR10108:SF24; 1.
DR Pfam; PF01209; Ubie_methyltran; 1.
DR TIGRFAMs; TIGR01934; MenG_MenH_UbiE; 1.
DR PROSITE; PS01183; UBIE_1; 1.
DR PROSITE; PS01184; UBIE_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Menaquinone biosynthesis; Methyltransferase;
KW Transferase.
FT CHAIN 1 230 Demethylmenaquinone methyltransferase.
FT /FTId=PRO_0000193296.
SQ SEQUENCE 230 AA; 24718 MW; AECA0F303D8A9774 CRC64;
MSRAELDKNP RDVASMFDGV ARRYDLTNTV LSLGQDRYWR KATRSALGIG PGQKVLDLAA
GTAVSTVELN KSGAWCVAAD FSVGMLAAGA ARRVPKVAGD ATRLPFADDV FDAVTISFGL
RNVVDTQAAL REMARVTRPG GRLVVCEFST PSNALFATVY KEYLMRALPR VARAVSSNPD
AYVYLAESIR AWPDQAALAD QIAGAGWAGV RWRNLTGGIV ALHAAHRPPR
//
