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Database: UniProt
Entry: Q73SL8
LinkDB: Q73SL8
Original site: Q73SL8 
ID   UBIE_MYCPA              Reviewed;         230 AA.
AC   Q73SL8;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 2.
DT   01-OCT-2014, entry version 70.
DE   RecName: Full=Demethylmenaquinone methyltransferase {ECO:0000255|HAMAP-Rule:MF_01813};
DE            EC=2.1.1.163 {ECO:0000255|HAMAP-Rule:MF_01813};
DE   AltName: Full=Menaquinone biosynthesis C-methyltransferase UbiE {ECO:0000255|HAMAP-Rule:MF_01813};
GN   Name=ubiE {ECO:0000255|HAMAP-Rule:MF_01813};
GN   OrderedLocusNames=MAP_4055;
OS   Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10).
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D.,
RA   Banerji N., Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- FUNCTION: Methyltransferase required for the conversion of
CC       demethylmenaquinone (DMKH2) to menaquinone (MKH2).
CC       {ECO:0000255|HAMAP-Rule:MF_01813}.
CC   -!- CATALYTIC ACTIVITY: A demethylmenaquinone + S-adenosyl-L-
CC       methionine = a menaquinol + S-adenosyl-L-homocysteine.
CC       {ECO:0000255|HAMAP-Rule:MF_01813}.
CC   -!- PATHWAY: Cofactor biosynthesis; menaquinone biosynthesis;
CC       menaquinone-2 from chorismate: step 8/8. {ECO:0000255|HAMAP-
CC       Rule:MF_01813}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. UbiE family. {ECO:0000255|HAMAP-
CC       Rule:MF_01813}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAS06605.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE016958; AAS06605.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_962989.2; NC_002944.2.
DR   ProteinModelPortal; Q73SL8; -.
DR   STRING; 262316.MAP4055; -.
DR   EnsemblBacteria; AAS06605; AAS06605; MAP_4055.
DR   GeneID; 2718963; -.
DR   KEGG; mpa:MAP4055; -.
DR   PATRIC; 18001023; VBIMycAvi108102_4317.
DR   eggNOG; COG2226; -.
DR   KO; K03183; -.
DR   OMA; YHYLAES; -.
DR   OrthoDB; EOG6M6JSB; -.
DR   BioCyc; MAVI262316:GCQR-4100-MONOMER; -.
DR   UniPathway; UPA00079; UER00169.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.150; -; 1.
DR   HAMAP; MF_01813; UbiE_methyltran; 1.
DR   InterPro; IPR029063; SAM-dependent_MTases-like.
DR   InterPro; IPR004033; UbiE/COQ5_MeTrFase.
DR   InterPro; IPR023576; UbiE/COQ5_MeTrFase_CS.
DR   Pfam; PF01209; Ubie_methyltran; 1.
DR   SUPFAM; SSF53335; SSF53335; 2.
DR   TIGRFAMs; TIGR01934; MenG_MenH_UbiE; 1.
DR   PROSITE; PS51608; SAM_MT_UBIE; 1.
DR   PROSITE; PS01183; UBIE_1; 1.
DR   PROSITE; PS01184; UBIE_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Menaquinone biosynthesis; Methyltransferase;
KW   Reference proteome; S-adenosyl-L-methionine; Transferase.
FT   CHAIN         1    230       Demethylmenaquinone methyltransferase.
FT                                /FTId=PRO_0000193296.
SQ   SEQUENCE   230 AA;  24718 MW;  AECA0F303D8A9774 CRC64;
     MSRAELDKNP RDVASMFDGV ARRYDLTNTV LSLGQDRYWR KATRSALGIG PGQKVLDLAA
     GTAVSTVELN KSGAWCVAAD FSVGMLAAGA ARRVPKVAGD ATRLPFADDV FDAVTISFGL
     RNVVDTQAAL REMARVTRPG GRLVVCEFST PSNALFATVY KEYLMRALPR VARAVSSNPD
     AYVYLAESIR AWPDQAALAD QIAGAGWAGV RWRNLTGGIV ALHAAHRPPR
//
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