ID PDXT_MYCPA Reviewed; 173 AA.
AC Q73WF2;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 01-MAY-2013, entry version 53.
DE RecName: Full=Glutamine amidotransferase subunit PdxT;
DE EC=2.6.-.-;
DE AltName: Full=Glutamine amidotransferase glutaminase subunit PdxT;
GN Name=pdxT; OrderedLocusNames=MAP_2708c;
OS Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10).
OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC Mycobacterium avium complex (MAC).
OX NCBI_TaxID=262316;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-968 / K-10;
RX PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D.,
RA Banerji N., Kanjilal S., Kapur V.;
RT "The complete genome sequence of Mycobacterium avium subspecies
RT paratuberculosis.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC -!- FUNCTION: Involved in the hydrolysis of glutamine to glutamate and
CC ammonia. Channels an ammonia molecule to PdxS (By similarity).
CC -!- PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate
CC biosynthesis.
CC -!- SUBUNIT: Forms a complex with PdxS (By similarity).
CC -!- SIMILARITY: Belongs to the glutamine amidotransferase PdxT/SNO
CC family.
CC -!- CAUTION: Glu-170 and Asp-172 are present instead of the conserved
CC His and Glu which are expected to be active site residues.
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DR EMBL; AE016958; AAS05025.1; -; Genomic_DNA.
DR RefSeq; NP_961642.1; NC_002944.2.
DR ProteinModelPortal; Q73WF2; -.
DR STRING; 262316.MAP2708c; -.
DR EnsemblBacteria; AAS05025; AAS05025; MAP_2708c.
DR GeneID; 2720021; -.
DR KEGG; mpa:MAP2708c; -.
DR PATRIC; 17998124; VBIMycAvi108102_2876.
DR eggNOG; COG0311; -.
DR KO; K08681; -.
DR OMA; FLAKEVR; -.
DR UniPathway; UPA00245; -.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0042823; P:pyridoxal phosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_01615; PdxT; 1; atypical.
DR InterPro; IPR002161; Glutamine_amidoTferase_suPdxT.
DR InterPro; IPR021196; PdxT/SNO_CS.
DR Pfam; PF01174; SNO; 1.
DR PIRSF; PIRSF005639; Glut_amidoT_SNO; 1.
DR TIGRFAMs; TIGR03800; PLP_synth_Pdx2; 1.
DR PROSITE; PS01236; PDXT_SNO_1; 1.
DR PROSITE; PS51130; PDXT_SNO_2; 1.
PE 3: Inferred from homology;
KW Complete proteome; Glutamine amidotransferase; Pyridoxal phosphate;
KW Transferase.
FT CHAIN 1 173 Glutamine amidotransferase subunit PdxT.
FT /FTId=PRO_0000135648.
FT ACT_SITE 81 81 Nucleophile (By similarity).
FT BINDING 113 113 Glutamine (Potential).
SQ SEQUENCE 173 AA; 18013 MW; F8E223AE281B0187 CRC64;
MSAPRIGVLA LQGDTREHLA ALREAGAESM PVRRRGELEA VDGLVIPGGE STTMSHLLKD
LDLLEPLRGL LADGLPAYGA CAGMILLASE ILDAGAGGRE ALPLRAIDMT VRRNAFGRQV
DSFEGDIAFA GLDGPVRAVF IRAPWVERAG DGVEVLARAA GHVVAVAGIE PDA
//
