ID   Q73Z73_MYCPA            Unreviewed;       340 AA.
AC   Q73Z73;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   RecName: Full=CobW C-terminal domain-containing protein {ECO:0000259|SMART:SM00833};
GN   OrderedLocusNames=MAP_1730c {ECO:0000313|EMBL:AAS04047.1};
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316 {ECO:0000313|EMBL:AAS04047.1, ECO:0000313|Proteomes:UP000000580};
RN   [1] {ECO:0000313|EMBL:AAS04047.1, ECO:0000313|Proteomes:UP000000580}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10 {ECO:0000313|Proteomes:UP000000580};
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC         Evidence={ECO:0000256|ARBA:ARBA00001702};
CC   -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC       subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR   EMBL; AE016958; AAS04047.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q73Z73; -.
DR   STRING; 262316.MAP_1730c; -.
DR   KEGG; mpa:MAP_1730c; -.
DR   eggNOG; COG0523; Bacteria.
DR   HOGENOM; CLU_017452_1_1_11; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd03112; CobW-like; 1.
DR   Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR036627; CobW-likC_sf.
DR   InterPro; IPR011629; CobW-like_C.
DR   InterPro; IPR003495; CobW/HypB/UreG_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR13748; COBW-RELATED; 1.
DR   PANTHER; PTHR13748:SF70; PROTEIN COBW; 1.
DR   Pfam; PF02492; cobW; 1.
DR   Pfam; PF07683; CobW_C; 1.
DR   SMART; SM00833; CobW_C; 1.
DR   SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000580}.
FT   DOMAIN          229..317
FT                   /note="CobW C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM00833"
SQ   SEQUENCE   340 AA;  35859 MW;  91934A9A6773CFA4 CRC64;
     MEGEALAAIP VIALTGHLGA GKTTLLNHLL RHPGTRIGVI VNDFGDINID AGLVAGQVDE
     PASIAGGCIC CLPDGGGLDE ALGKLADPAL RLDAIVVEAS GLADPVAIAR LIGFSEIRGV
     RPGGLVDVVD AVNHFDTVDR GPLPPVRYGA ASLIVVNKLD QVPERERSVV VQRVRERAAQ
     RNPRIHVVGT IGGRIAPELL FDASARPEQI GQLSFVDLVP EHEHDHVHAD AVTAHSDGCI
     DPDALLNLLE NPPPQVFRMK GVVAVRQRAT VRNYVVNLVG SAIDIAKAPP KATANRLVAI
     GMHLDVAAVG ARLDRALQPV YGPASGQASR RLQRYLRLSA
//