ID Q74D24_GEOSL Unreviewed; 458 AA.
AC Q74D24;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 139.
DE SubName: Full=Sigma-54-dependent transcriptional response regulator PilR {ECO:0000313|EMBL:AAR34869.1};
GN Name=pilR {ECO:0000313|EMBL:AAR34869.1};
GN OrderedLocusNames=GSU1495 {ECO:0000313|EMBL:AAR34869.1};
OS Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA).
OC Bacteria; Thermodesulfobacteriota; Desulfuromonadia; Geobacterales;
OC Geobacteraceae; Geobacter.
OX NCBI_TaxID=243231 {ECO:0000313|EMBL:AAR34869.1, ECO:0000313|Proteomes:UP000000577};
RN [1] {ECO:0000313|EMBL:AAR34869.1, ECO:0000313|Proteomes:UP000000577}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51573 / DSM 12127 / PCA
RC {ECO:0000313|Proteomes:UP000000577};
RX PubMed=14671304; DOI=10.1126/science.1088727;
RA Methe B.A., Nelson K.E., Eisen J.A., Paulsen I.T., Nelson W.,
RA Heidelberg J.F., Wu D., Wu M., Ward N., Beanan M.J., Dodson R.J.,
RA Madupu R., Brinkac L.M., Daugherty S.C., DeBoy R.T., Durkin A.S., Gwinn M.,
RA Kolonay J.F., Sullivan S.A., Haft D.H., Selengut J., Davidsen T.M.,
RA Zafar N., White O., Tran B., Romero C., Forberger H.A., Weidman J.,
RA Khouri H., Feldblyum T.V., Utterback T.R., Van Aken S.E., Lovley D.R.,
RA Fraser C.M.;
RT "Genome of Geobacter sulfurreducens: metal reduction in subsurface
RT environments.";
RL Science 302:1967-1969(2003).
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DR EMBL; AE017180; AAR34869.1; -; Genomic_DNA.
DR RefSeq; NP_952546.1; NC_002939.5.
DR RefSeq; WP_010942141.1; NC_002939.5.
DR AlphaFoldDB; Q74D24; -.
DR SMR; Q74D24; -.
DR STRING; 243231.GSU1495; -.
DR EnsemblBacteria; AAR34869; AAR34869; GSU1495.
DR KEGG; gsu:GSU1495; -.
DR PATRIC; fig|243231.5.peg.1541; -.
DR eggNOG; COG2204; Bacteria.
DR HOGENOM; CLU_000445_0_6_7; -.
DR InParanoid; Q74D24; -.
DR OrthoDB; 9814761at2; -.
DR Proteomes; UP000000577; Chromosome.
DR CollecTF; EXPREG_00000f70; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEP:CollecTF.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR002197; HTH_Fis.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR002078; Sigma_54_int.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR025943; Sigma_54_int_dom_ATP-bd_2.
DR InterPro; IPR025944; Sigma_54_int_dom_CS.
DR PANTHER; PTHR32071:SF113; HYDROGENASE TRANSCRIPTIONAL REGULATORY PROTEIN HOXA; 1.
DR PANTHER; PTHR32071; TRANSCRIPTIONAL REGULATORY PROTEIN; 1.
DR Pfam; PF02954; HTH_8; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00158; Sigma54_activat; 1.
DR PRINTS; PR01590; HTHFIS.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS00676; SIGMA54_INTERACT_2; 1.
DR PROSITE; PS00688; SIGMA54_INTERACT_3; 1.
DR PROSITE; PS50045; SIGMA54_INTERACT_4; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|PROSITE-ProRule:PRU00169};
KW Reference proteome {ECO:0000313|Proteomes:UP000000577};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 4..118
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 143..371
FT /note="Sigma-54 factor interaction"
FT /evidence="ECO:0000259|PROSITE:PS50045"
FT MOD_RES 53
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 458 AA; 51457 MW; 48272E22F2D9E3F8 CRC64;
MEIHVLVVDD ELSMREFLAI LLDREGYTVD QAASAEEALA CLERKTYDLV ISDVKMPGLD
GITLLGRIKE MTPDTAVLLM TAFSTAEQAV EAMKLGAYDY IAKPFKVEEV KILARNALEK
RDLKRENLRL RQEVQERYSF SGLIGKSKKM REVYSLIEKV APSTANVLIL GESGTGKELV
ARAIHYNSQR KGKPFVAVNC GAIPETLMES EFFGHKKGAF TGAVGDRAGL FEQAEGGTLF
LDEIGEVPLQ LQAKLLRAIQ EKEFRRVGGT LDQKADVRLV AASNRDLEEQ VKEGSFREDL
FYRLNVVQVK MPPLRERGDD IPILVEHFYK KYVQPPYSDR IITQGALKLL MSYGFPGNVR
ELENLVERCS VLGNREISEE CLPPQLHAGK RPECGAVTEC ELPEEGMDLE AYLDGIEKRI
LLQALERSGG VKKKAAELLK LTFRSFRYRL AKFGMDEE
//
