ID   KTHY_LACJO              Reviewed;         213 AA.
AC   Q74KZ7;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   01-MAY-2013, entry version 58.
DE   RecName: Full=Thymidylate kinase;
DE            EC=2.7.4.9;
DE   AltName: Full=dTMP kinase;
GN   Name=tmk; OrderedLocusNames=LJ_0427;
OS   Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=257314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CNCM I-1225 / La1 / NCC 533;
RX   PubMed=14983040; DOI=10.1073/pnas.0307327101;
RA   Pridmore R.D., Berger B., Desiere F., Vilanova D., Barretto C.,
RA   Pittet A.-C., Zwahlen M.-C., Rouvet M., Altermann E., Barrangou R.,
RA   Mollet B., Mercenier A., Klaenhammer T., Arigoni F., Schell M.A.;
RT   "The genome sequence of the probiotic intestinal bacterium
RT   Lactobacillus johnsonii NCC 533.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2512-2517(2004).
CC   -!- FUNCTION: Phosphorylation of dTMP to form dTDP in both de novo and
CC       salvage pathways of dTTP synthesis (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + dTMP = ADP + dTDP.
CC   -!- SIMILARITY: Belongs to the thymidylate kinase family.
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DR   EMBL; AE017198; AAS08418.1; -; Genomic_DNA.
DR   RefSeq; NP_964452.1; NC_005362.1.
DR   ProteinModelPortal; Q74KZ7; -.
DR   STRING; 257314.LJ0427; -.
DR   EnsemblBacteria; AAS08418; AAS08418; LJ_0427.
DR   GeneID; 2743708; -.
DR   KEGG; ljo:LJ0427; -.
DR   PATRIC; 22237528; VBILacJoh1832_0453.
DR   eggNOG; COG0125; -.
DR   KO; K00943; -.
DR   OMA; ITLEGPE; -.
DR   ProtClustDB; PRK00698; -.
DR   BioCyc; LJOH257314:GJN3-450-MONOMER; -.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004798; F:thymidylate kinase activity; IEA:HAMAP.
DR   GO; GO:0006233; P:dTDP biosynthetic process; IEA:InterPro.
DR   GO; GO:0006235; P:dTTP biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00165; Thymidylate_kinase; 1; -.
DR   InterPro; IPR018095; Thymidylate_kin_CS.
DR   InterPro; IPR018094; Thymidylate_kinase.
DR   PANTHER; PTHR10344; PTHR10344; 1.
DR   TIGRFAMs; TIGR00041; DTMP_kinase; 1.
DR   PROSITE; PS01331; THYMIDYLATE_KINASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Kinase; Nucleotide biosynthesis;
KW   Nucleotide-binding; Transferase.
FT   CHAIN         1    213       Thymidylate kinase.
FT                                /FTId=PRO_0000155287.
FT   NP_BIND      10     17       ATP (Potential).
SQ   SEQUENCE   213 AA;  23966 MW;  89E9B199780F6E3F CRC64;
     MRGYLITFEG PDGAGKTTVI NEIIKQLPQS LQERTLVTRE PGGSKISENI RTIILDPENK
     EMDDRTEALL YAAQRSQHVS EVIRPALATG KVVLSDRFID SSLAYQGVGR NLGIEEVKQI
     NDFGTGGLEP DLTIFLDLDP AVGLARIEKE RAGQEDRLEQ EKIDFHNKVY AGYRELFERY
     PDRIKKVDAN LPIKDVAANS VKIIRKQLPD IFM
//