ID Q74MI0_NANEQ Unreviewed; 344 AA.
AC Q74MI0;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 131.
DE RecName: Full=ORC1-type DNA replication protein {ECO:0000256|HAMAP-Rule:MF_01407};
GN OrderedLocusNames=NEQ057 {ECO:0000313|EMBL:AAR38911.1};
OS Nanoarchaeum equitans (strain Kin4-M).
OC Archaea; Nanoarchaeota; Candidatus Nanoarchaeia; Nanoarchaeales;
OC Nanoarchaeaceae; Nanoarchaeum.
OX NCBI_TaxID=228908 {ECO:0000313|EMBL:AAR38911.1, ECO:0000313|Proteomes:UP000000578};
RN [1] {ECO:0000313|EMBL:AAR38911.1, ECO:0000313|Proteomes:UP000000578}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Kin4-M {ECO:0000313|EMBL:AAR38911.1,
RC ECO:0000313|Proteomes:UP000000578};
RX PubMed=14566062; DOI=10.1073/pnas.1735403100;
RA Waters E., Hohn M.J., Ahel I., Graham D.E., Adams M.D., Barnstead M.,
RA Beeson K.Y., Bibbs L., Bolanos R., Keller M., Kretz K., Lin X., Mathur E.,
RA Ni J., Podar M., Richardson T., Sutton G.G., Simon M., Soll D.,
RA Stetter K.O., Short J.M., Noordewier M.;
RT "The genome of Nanoarchaeum equitans: insights into early archaeal
RT evolution and derived parasitism.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:12984-12988(2003).
CC -!- FUNCTION: Involved in regulation of DNA replication.
CC {ECO:0000256|HAMAP-Rule:MF_01407}.
CC -!- SIMILARITY: Belongs to the CDC6/cdc18 family. {ECO:0000256|HAMAP-
CC Rule:MF_01407}.
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DR EMBL; AE017199; AAR38911.1; -; Genomic_DNA.
DR AlphaFoldDB; Q74MI0; -.
DR STRING; 228908.NEQ057; -.
DR EnsemblBacteria; AAR38911; AAR38911; NEQ057.
DR KEGG; neq:NEQ057; -.
DR HOGENOM; CLU_025112_3_1_2; -.
DR BioCyc; NEQU228908:GJB6-60-MONOMER; -.
DR Proteomes; UP000000578; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniRule.
DR CDD; cd18139; HLD_clamp_RarA; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_01407; ORC1_type_DNA_replic_protein; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR015163; Cdc6_C.
DR InterPro; IPR014277; Orc1/Cdc6_arc.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR02928; orc1/cdc6 family replication initiation protein; 1.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10763:SF22; ORC1-TYPE DNA REPLICATION PROTEIN 3; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF09079; Cdc6_C; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SMART; SM01074; Cdc6_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_01407};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW Rule:MF_01407}; Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01407};
KW Reference proteome {ECO:0000313|Proteomes:UP000000578}.
FT DOMAIN 41..176
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 270..344
FT /note="Cdc6 C-terminal"
FT /evidence="ECO:0000259|SMART:SM01074"
FT BINDING 53..57
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01407"
FT BINDING 175
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01407"
FT BINDING 187
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01407"
SQ SEQUENCE 344 AA; 39394 MW; 9267D040D0B6AB03 CRC64;
MPIFKNRFVF SEAYVPSKIL HRDDEISLIY TAISPIKQGE KPLNIFIYGQ TGTGKTLVTK
YVLSKIGDYI YINCKFAGIT KRIESFIREF SLQLGQDFYD LTDVIQYIRD KKLIIVFDEV
DQLSKDLGDE ILYTFTRAPG NIGIIGISNN IFFVDRLDPR VRSSLSELEI LFKPYNALQL
RDILLERAKE GLYENSYDLA AISYIAAVTA REYGDARRAI NLLRLAGEIA ERKGKNKIEL
EDAKEAIELE EKDKVKFVIE SLPLQSKLVL KSIAELKDTT LGKAYELYYR KSLEKSVTPI
TFRRFVEIVN DLETLGLVSI DFALLNGKRV RKVKTFISPK IIDL
//
