ID Q75TL3_SALIN Unreviewed; 263 AA.
AC Q75TL3;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 91.
DE RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252, ECO:0000256|PIRNR:PIRNR000819};
DE EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126, ECO:0000256|PIRNR:PIRNR000819};
GN Name=aadA1 {ECO:0000313|EMBL:BAD02326.1};
GN ORFNames=DKR80_22870 {ECO:0000313|EMBL:ECS9071348.1}, DKR80_25875
GN {ECO:0000313|EMBL:ECS9071859.1}, GDL33_22995
GN {ECO:0000313|EMBL:HAA0876245.1};
OS Salmonella infantis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=595 {ECO:0000313|EMBL:BAD02326.1};
RN [1] {ECO:0000313|EMBL:ABB72058.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SRC70 {ECO:0000313|EMBL:ABB72058.1};
RX PubMed=7695299;
RA Collis C.M., Hall R.M.;
RT "Expression of antibiotic resistance genes in the integrated cassettes of
RT integrons.";
RL Antimicrob. Agents Chemother. 39:155-162(1995).
RN [2] {ECO:0000313|EMBL:BAD02326.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SI01083 {ECO:0000313|EMBL:BAD02326.1};
RA Ahmed A.M., Nakano H., Shimamoto T.;
RT "Detection and characterization of Class 1 integron in S.infantis strain
RT SI01083.";
RL Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:BAD02328.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=J-C1 {ECO:0000313|EMBL:BAD02328.1};
RX PubMed=15705645; DOI=10.1093/jac/dkh534;
RA Ahmed A.M., Nakano H., Shimamoto T.;
RT "Molecular characterization of integrons in non-typhoid Salmonella serovars
RT isolated in Japan: description of an unusual class 2 integron.";
RL J. Antimicrob. Chemother. 55:371-374(2005).
RN [4] {ECO:0000313|EMBL:ABB72058.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SRC70 {ECO:0000313|EMBL:ABB72058.1};
RX PubMed=16870788; DOI=10.1128/AAC.00449-06;
RA Levings R.S., Lightfoot D., Elbourne L.D., Djordjevic S.P., Hall R.M.;
RT "New integron-associated gene cassette encoding a trimethoprim-resistant
RT DfrB-type dihydrofolate reductase.";
RL Antimicrob. Agents Chemother. 50:2863-2865(2006).
RN [5] {ECO:0000313|EMBL:HAA0876245.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=13-3055 {ECO:0000313|EMBL:HAA0876245.1};
RX PubMed=30286803;
RA Souvorov A., Agarwala R., Lipman D.J.;
RT "SKESA: strategic k-mer extension for scrupulous assemblies.";
RL Genome Biol. 19:153-153(2018).
RN [6] {ECO:0000313|EMBL:ECS9071348.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSIS11809892 {ECO:0000313|EMBL:ECS9071348.1};
RG GenomeTrakr network: Whole genome sequencing for foodborne pathogen traceback;
RL Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:HAA0876245.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=13-3055 {ECO:0000313|EMBL:HAA0876245.1};
RG NCBI Pathogen Detection Project;
RL Submitted (OCT-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC Evidence={ECO:0000256|ARBA:ARBA00001672,
CC ECO:0000256|PIRNR:PIRNR000819};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC Evidence={ECO:0000256|ARBA:ARBA00035070,
CC ECO:0000256|PIRNR:PIRNR000819};
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DR EMBL; DQ274503; ABB72058.1; -; Genomic_DNA.
DR EMBL; AB126599; BAD02326.1; -; Genomic_DNA.
DR EMBL; AB126601; BAD02328.1; -; Genomic_DNA.
DR EMBL; AAKLCC010000055; ECS9071348.1; -; Genomic_DNA.
DR EMBL; AAKLCC010000120; ECS9071859.1; -; Genomic_DNA.
DR EMBL; DAAAKK010000029; HAA0876245.1; -; Genomic_DNA.
DR PATRIC; fig|595.34.peg.1891; -.
DR Proteomes; UP000839930; Unassembled WGS sequence.
DR GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd05403; NT_KNTase_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR024172; AadA/Aad9.
DR InterPro; IPR025184; AadA_C.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR Pfam; PF13427; AadA_C; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW ECO:0000256|PIRNR:PIRNR000819};
KW ATP-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000819,
KW ECO:0000313|EMBL:ABB72058.1};
KW Transferase {ECO:0000256|PIRNR:PIRNR000819, ECO:0000313|EMBL:BAD02326.1}.
FT DOMAIN 28..76
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 152..254
FT /note="Adenylyltransferase AadA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13427"
SQ SEQUENCE 263 AA; 29332 MW; D2CEAC8B7D403FD2 CRC64;
MREAVIAEVS TQLSEVVGVI ERHLEPTLLA VHLYGSAVDG GLKPHSDIDL LVTVTVRLDE
TTRRALINDL LETSASPGES EILRAVEVTI VVHDDIIPWR YPAKRELQFG EWQRNDILAG
IFEPATIDID LAILLTKARE HSVALVGPAA EELFDPVPEQ DLFEALNETL TLWNSPPDWA
GDERNVVLTL SRIWYSAVTG KIAPKDVAAD WAMERLPAQY QPVILEARQA YLGQEEDRLA
SRADQLEEFV HYVKGEITKV VGK
//