ID   Q75XT5_HUMAN            Unreviewed;       287 AA.
AC   Q75XT5;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 73.
DE   SubName: Full=UDP-glucuronosyltransferase {ECO:0000313|EMBL:BAD12518.1};
DE   Flags: Fragment;
GN   Name=UGT1A3 {ECO:0000313|EMBL:BAD12518.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAD12518.1};
RN   [1] {ECO:0000313|EMBL:BAD12518.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Iwai M., Maruo Y., Ito M., Yamamoto K., Sato H., Takeuchi Y.;
RT   "Six novel UDP-glucuronosyltransferase (UGT1A3) polymorphisms with varying
RT   activity.";
RL   J. Hum. Genet. 48:123-128(2004).
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DR   EMBL; AB120360; BAD12518.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q75XT5; -.
DR   PeptideAtlas; Q75XT5; -.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019899; F:enzyme binding; IEA:UniProt.
DR   GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProt.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:UniProt.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:UniProt.
DR   GO; GO:0052695; P:cellular glucuronidation; IEA:UniProt.
DR   Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 1.
DR   InterPro; IPR002213; UDP_glucos_trans.
DR   PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR48043:SF166; UD11 GLUCURONOSYLTRANSFERASE; 1.
DR   Pfam; PF00201; UDPGT; 1.
DR   SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE   4: Predicted;
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136}; Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:BAD12518.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..287
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5004286083"
FT   NON_TER         287
FT                   /evidence="ECO:0000313|EMBL:BAD12518.1"
SQ   SEQUENCE   287 AA;  32754 MW;  A38F19F51A461A4A CRC64;
     MATGLRVPLP RLATGLLLLL SVQPWAESGK VLVVPIDGSH WLSMREVLRE LHARGHQAVV
     LTPEVNMHIK EENFFTLTTY AISWTQDEFD RHVLGHTQLY FETEHFLKKF FRSMAMLNNM
     SLVYHRSCVE LLHNEALIRH LNATSFDVVL TDPVNLCAAV LAKYLSIPTV FFLRNIPCDL
     DFKGTQCPNP SSYIPRLLTT NSDHMTFMQR VKNMLYPLAL SYICHAFSAP YASLASELFQ
     REVSVVDILS HASVWLFRGD FVMDYPRPIM PNMVFIGGIN CANRKPL
//