ID Q76KE4_BURCE Unreviewed; 150 AA.
AC Q76KE4;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=siroheme decarboxylase {ECO:0000256|ARBA:ARBA00023471};
DE EC=4.1.1.111 {ECO:0000256|ARBA:ARBA00023471};
GN Name=nirD {ECO:0000313|EMBL:BAD11783.1};
OS Burkholderia cepacia (Pseudomonas cepacia).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=292 {ECO:0000313|EMBL:BAD11783.1};
RN [1] {ECO:0000313|EMBL:BAD11783.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NH-17 {ECO:0000313|EMBL:BAD11783.1};
RA Matsuzaka E., Nomura N., Maseda H., Otagaki H., Kambe T.N., Nakahara T.,
RA Uchiyama H.;
RT "Participation of nitrite reductase in conversion of NO2- to NO3- in a
RT heterotrophic nitrifier, Burkholderia cepacia NH-17, with denitrification
RT activity.";
RL Microbes Environ. 18:203-209(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 H(+) + siroheme = 12,18-didecarboxysiroheme + 2 CO2;
CC Xref=Rhea:RHEA:19093, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:60052, ChEBI:CHEBI:140497; EC=4.1.1.111;
CC Evidence={ECO:0000256|ARBA:ARBA00023409};
CC -!- PATHWAY: Porphyrin-containing compound metabolism.
CC {ECO:0000256|ARBA:ARBA00023444}.
CC -!- SIMILARITY: Belongs to the Ahb/Nir family.
CC {ECO:0000256|ARBA:ARBA00023457}.
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DR EMBL; AB092344; BAD11783.1; -; Genomic_DNA.
DR AlphaFoldDB; Q76KE4; -.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR Gene3D; 3.30.70.3460; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000485; AsnC-type_HTH_dom.
DR InterPro; IPR040523; AsnC_trans_reg2.
DR InterPro; IPR019888; Tscrpt_reg_AsnC-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR43413:SF1; SIROHEME DECARBOXYLASE NIRL SUBUNIT; 1.
DR PANTHER; PTHR43413; TRANSCRIPTIONAL REGULATOR, ASNC FAMILY; 1.
DR Pfam; PF17805; AsnC_trans_reg2; 1.
DR Pfam; PF13404; HTH_AsnC-type; 1.
DR SMART; SM00344; HTH_ASNC; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000256|ARBA:ARBA00023239}.
FT DOMAIN 1..45
FT /note="HTH asnC-type"
FT /evidence="ECO:0000259|Pfam:PF13404"
FT DOMAIN 64..132
FT /note="Siroheme decarboxylase AsnC-like ligand binding"
FT /evidence="ECO:0000259|Pfam:PF17805"
SQ SEQUENCE 150 AA; 17047 MW; 89B48D35D91AFDC6 CRC64;
MDDLSRRLIA RYQKGLPICA EPYRRMAETL GCSEAEVLER LRRLEADGAL SRVGPVLRHQ
RAGASTLAAL AVPEERLQRV TERISQYAEV NHNYQREHRY NLWFVLTAGD RAQLDRVLAE
IAADTGLQPL DLPMQEAYCI DLAFPLEASR
//
