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Database: UniProt
Entry: Q78EA7
LinkDB: Q78EA7
Original site: Q78EA7 
ID   BMR1A_RAT               Reviewed;         532 AA.
AC   Q78EA7; Q64308;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-SEP-2014, entry version 93.
DE   RecName: Full=Bone morphogenetic protein receptor type-1A;
DE            Short=BMP type-1A receptor;
DE            Short=BMPR-1A;
DE            EC=2.7.11.30;
DE   AltName: Full=Activin receptor-like kinase 3;
DE            Short=ALK-3;
DE   AltName: Full=Bone morphogenetic protein 4 receptor;
DE   AltName: CD_antigen=CD292;
DE   Flags: Precursor;
GN   Name=Bmpr1a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7897267;
RA   Takeda K.;
RT   "Expression of serine/threonine kinase receptors during ectopic bone
RT   formation induced by bone morphogenetic protein (BMP).";
RL   Kokubyo Gakkai Zasshi 61:512-526(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Dental pulp;
RX   PubMed=7945360; DOI=10.1006/bbrc.1994.2445;
RA   Takeda K., Oida S., Ichijo H., Iimura T., Maruoka Y., Amagasa T.,
RA   Sasaki S.;
RT   "Molecular cloning of rat bone morphogenetic protein (BMP) type IA
RT   receptor and its expression during ectopic bone formation induced by
RT   BMP.";
RL   Biochem. Biophys. Res. Commun. 204:203-209(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar; TISSUE=Brain;
RA   Ikeda T., Takahashi H.;
RT   "Expression pattern of bone morphogenetic protein 4 receptor in embryo
RT   and adult rat.";
RL   Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: On ligand binding, forms a receptor complex consisting
CC       of two type II and two type I transmembrane serine/threonine
CC       kinases. Type II receptors phosphorylate and activate type I
CC       receptors which autophosphorylate, then bind and activate SMAD
CC       transcriptional regulators. Receptor for BMP-2 and BMP-4 (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-
CC       protein] phosphate.
CC   -!- COFACTOR: Magnesium or manganese (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC   -!- SIMILARITY: Contains 1 GS domain.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
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DR   EMBL; S75359; AAB33865.1; -; mRNA.
DR   EMBL; D38082; BAA07275.1; -; mRNA.
DR   EMBL; D17667; BAA04549.1; -; mRNA.
DR   PIR; JC2387; JC2387.
DR   RefSeq; NP_110476.1; NM_030849.1.
DR   UniGene; Rn.88925; -.
DR   ProteinModelPortal; Q78EA7; -.
DR   SMR; Q78EA7; 55-146, 200-528.
DR   BioGrid; 249504; 1.
DR   GuidetoPHARMACOLOGY; 1786; -.
DR   PhosphoSite; Q78EA7; -.
DR   Ensembl; ENSRNOT00000015047; ENSRNOP00000015047; ENSRNOG00000010814.
DR   GeneID; 81507; -.
DR   KEGG; rno:81507; -.
DR   UCSC; RGD:70989; rat.
DR   CTD; 657; -.
DR   RGD; 70989; Bmpr1a.
DR   eggNOG; COG0515; -.
DR   GeneTree; ENSGT00730000110337; -.
DR   HOGENOM; HOG000230587; -.
DR   HOVERGEN; HBG054502; -.
DR   InParanoid; Q78EA7; -.
DR   KO; K04673; -.
DR   OMA; CYNRDLE; -.
DR   OrthoDB; EOG7Q8CN3; -.
DR   PhylomeDB; Q78EA7; -.
DR   TreeFam; TF314724; -.
DR   NextBio; 614971; -.
DR   PRO; PR:Q78EA7; -.
DR   Genevestigator; Q78EA7; -.
DR   GO; GO:0005901; C:caveola; IEA:Ensembl.
DR   GO; GO:0030425; C:dendrite; IDA:RGD.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004702; F:receptor signaling protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IEA:Ensembl.
DR   GO; GO:0005024; F:transforming growth factor beta-activated receptor activity; IEA:InterPro.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR   GO; GO:0048589; P:developmental growth; IEA:Ensembl.
DR   GO; GO:0009950; P:dorsal/ventral axis specification; IEA:Ensembl.
DR   GO; GO:0007398; P:ectoderm development; IEA:Ensembl.
DR   GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
DR   GO; GO:0048568; P:embryonic organ development; IEA:Ensembl.
DR   GO; GO:0003272; P:endocardial cushion formation; IEA:Ensembl.
DR   GO; GO:0060914; P:heart formation; IEA:Ensembl.
DR   GO; GO:0035137; P:hindlimb morphogenesis; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:Ensembl.
DR   GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR   GO; GO:0048368; P:lateral mesoderm development; IEA:Ensembl.
DR   GO; GO:0030324; P:lung development; IEA:Ensembl.
DR   GO; GO:0048382; P:mesendoderm development; IEA:Ensembl.
DR   GO; GO:0001707; P:mesoderm formation; IEA:Ensembl.
DR   GO; GO:0001880; P:Mullerian duct regression; IEA:Ensembl.
DR   GO; GO:0050768; P:negative regulation of neurogenesis; IEA:Ensembl.
DR   GO; GO:0014032; P:neural crest cell development; IEA:Ensembl.
DR   GO; GO:0021998; P:neural plate mediolateral regionalization; IEA:Ensembl.
DR   GO; GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Ensembl.
DR   GO; GO:0060021; P:palate development; IEA:Ensembl.
DR   GO; GO:0048352; P:paraxial mesoderm structural organization; IEA:Ensembl.
DR   GO; GO:0021983; P:pituitary gland development; IEA:Ensembl.
DR   GO; GO:0030501; P:positive regulation of bone mineralization; IEA:Ensembl.
DR   GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR   GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IEA:Ensembl.
DR   GO; GO:0045669; P:positive regulation of osteoblast differentiation; IEA:Ensembl.
DR   GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
DR   GO; GO:0060391; P:positive regulation of SMAD protein import into nucleus; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:Ensembl.
DR   GO; GO:0048378; P:regulation of lateral mesodermal cell fate specification; IEA:Ensembl.
DR   GO; GO:0001756; P:somitogenesis; IEA:Ensembl.
DR   GO; GO:0019827; P:stem cell maintenance; IEA:Ensembl.
DR   InterPro; IPR000472; Activin_rcpt.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR003605; TGF_beta_rcpt_GS.
DR   InterPro; IPR000333; TGFB_receptor.
DR   PANTHER; PTHR23255; PTHR23255; 1.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   SMART; SM00467; GS; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Disulfide bond; Glycoprotein; Kinase;
KW   Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding;
KW   Receptor; Reference proteome; Serine/threonine-protein kinase; Signal;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     23       Potential.
FT   CHAIN        24    532       Bone morphogenetic protein receptor type-
FT                                1A.
FT                                /FTId=PRO_0000254907.
FT   TOPO_DOM     24    152       Extracellular (Potential).
FT   TRANSMEM    153    176       Helical; (Potential).
FT   TOPO_DOM    177    532       Cytoplasmic (Potential).
FT   DOMAIN      204    233       GS.
FT   DOMAIN      234    525       Protein kinase.
FT   NP_BIND     240    248       ATP (By similarity).
FT   REGION      107    109       Mediates specificity for BMP ligand (By
FT                                similarity).
FT   ACT_SITE    362    362       Proton acceptor (By similarity).
FT   BINDING     261    261       ATP (By similarity).
FT   CARBOHYD     73     73       N-linked (GlcNAc...) (Potential).
FT   DISULFID     61     82       By similarity.
FT   DISULFID     63     67       By similarity.
FT   DISULFID     76    100       By similarity.
FT   DISULFID    110    124       By similarity.
FT   DISULFID    125    130       By similarity.
SQ   SEQUENCE   532 AA;  59994 MW;  14ED4C03E2540A0C CRC64;
     MTQLYTYIRL LGACLFIISH VQGQNLDSML HGTGMKSDVD QKKPENGVTL APEDTLPFLK
     CYCSGHCPDD AINNTCITNG HCFAIIEEDD QGETTLTSGC MKYEGSDFQC KDSPKAQLRR
     TIECCRTNLC NQYLQPTLPP VVIGPFFDGS VRWLAVLISM AVCIVAMIVF SSCFCYKHYC
     KSISSRGRYN RDLEQDEAFI PVGESLKDLI DQSQSSGSGS GLPLLVQRTI AKQIQMVRQV
     GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT VLMRHENILG FIAADIKGTG
     SWTQLYLITD YHENGSLYDF LKCATLDTRA LLKLAYSAAC GLCHLHTEIY GTQGKPAIAH
     RDLKSKNILI KKNGSCCIAD LGLAVKFNSD TNEVDIPLNT RVGTRRYMAP EVLDESLSKN
     HFQPYIMADI YSFGLIIWEM ARRCITGGIV EEYQLPYYNM VPSDPSYEDM REVVCVKRLR
     PIVSNRWNSD ECLRAVLKLM SECWAHNPAS RLTALRIKKT LAKMVESQDV KI
//
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