ID Q79D85_PSEAI Unreviewed; 259 AA.
AC Q79D85;
DT 05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2004, sequence version 1.
DT 24-JAN-2024, entry version 76.
DE RecName: Full=Aminoglycoside (3'') (9) adenylyltransferase {ECO:0000256|ARBA:ARBA00035252, ECO:0000256|PIRNR:PIRNR000819};
DE EC=2.7.7.47 {ECO:0000256|ARBA:ARBA00035126, ECO:0000256|PIRNR:PIRNR000819};
GN Name=aadA2 {ECO:0000313|EMBL:AAB60002.1};
OS Pseudomonas aeruginosa.
OG Plasmid R1033 {ECO:0000313|EMBL:AAB60002.1}.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=287 {ECO:0000313|EMBL:AAB60002.1};
RN [1] {ECO:0000313|EMBL:AAB60002.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=R1033 {ECO:0000313|EMBL:AAB60002.1};
RX PubMed=2549372; DOI=10.1007/BF02464882;
RA Wohlleben W., Arnold W., Bissonette L., Palletier A., Tanguay A., Roy P.H.,
RA Gamboa G.C., Barry G.F., Aubert E., Davies J., Kagan S.A.;
RT "On the evolution of Tn21-like multiresistance transposons: sequence
RT analysis of the gene (aacC1) for gentamicin acetyltransferase-3-I(AAC(3)-
RT I), another member of the Tn21-based expression cassette.";
RL Mol. Gen. Genet. 217:202-208(1989).
RN [2] {ECO:0000313|EMBL:AAB60002.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=R1033 {ECO:0000313|EMBL:AAB60002.1};
RX PubMed=1648560;
RA Bissonnette L., Champetier S., Buisson J.P., Roy P.H.;
RT "Characterization of the nonenzymatic chloramphenicol resistance (cmlA)
RT gene of the In4 integron of Tn1696: similarity of the product to
RT transmembrane transport proteins.";
RL J. Bacteriol. 173:4493-4502(1991).
RN [3] {ECO:0000313|EMBL:AAB60002.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=R1033 {ECO:0000313|EMBL:AAB60002.1};
RX PubMed=1658833; DOI=10.1016/0147-619X(91)90032-R;
RA Stokes H.W., Hall R.M.;
RT "Sequence analysis of the inducible chloramphenicol resistance determinant
RT in the Tn1696 integron suggests regulation by translational attenuation.";
RL Plasmid 26:10-19(1991).
RN [4] {ECO:0000313|EMBL:AAB60002.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=R1033 {ECO:0000313|EMBL:AAB60002.1};
RX PubMed=1311297;
RA Collis C.M., Hall R.M.;
RT "Site-specific deletion and rearrangement of integron insert genes
RT catalyzed by the integron DNA integrase.";
RL J. Bacteriol. 174:1574-1585(1992).
RN [5] {ECO:0000313|EMBL:AAB60002.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=R1033 {ECO:0000313|EMBL:AAB60002.1};
RA Stokes H.W.;
RL Submitted (JUL-1994) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AAB60002.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=R1033 {ECO:0000313|EMBL:AAB60002.1};
RA Partridge S., Hall R.M.;
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:CAG23930.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=85MG {ECO:0000313|EMBL:CAG23930.1};
RX PubMed=17021059; DOI=10.1128/JCM.00817-06;
RA Giske C.G., Libisch B., Colinon C., Scoulica E., Pagani L., Fuzi M.,
RA Kronvall G., Rossolini G.M.;
RT "Establishing clonal relationships between VIM-1-like metallo-beta-
RT lactamase-producing Pseudomonas aeruginosa strains from four European
RT countries by multilocus sequence typing.";
RL J. Clin. Microbiol. 44:4309-4315(2006).
RN [8] {ECO:0000313|EMBL:AAZ07711.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=17122024; DOI=10.1128/JCM.01318-06;
RA Gu B., Tong M., Zhao W., Liu G., Ning M., Pan S., Zhao W.;
RT "Prevalence and characterization of class I integrons among Pseudomonas
RT aeruginosa and Acinetobacter baumannii isolates from patients in Nanjing,
RT China.";
RL J. Clin. Microbiol. 45:241-243(2007).
RN [9] {ECO:0000313|EMBL:ABY48979.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=05-279 {ECO:0000313|EMBL:ABY48979.1};
RX PubMed=19049645; DOI=10.1111/j.1574-695X.2008.00483.x;
RA Libisch B., Poirel L., Lepsanovic Z., Mirovic V., Balogh B., Paszti J.,
RA Hunyadi Z., Dobak A., Fuzi M., Nordmann P.;
RT "Identification of PER-1 extended-spectrum beta-lactamase producing
RT Pseudomonas aeruginosa clinical isolates of the international clonal
RT complex CC11 from Hungary and Serbia.";
RL FEMS Immunol. Med. Microbiol. 54:330-338(2008).
RN [10] {ECO:0000313|EMBL:AAB60002.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=R1033 {ECO:0000313|EMBL:AAB60002.1};
RA Pinyon J.L., Hall R.M.;
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
RN [11] {ECO:0000313|EMBL:ADL40248.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=R1033 {ECO:0000313|EMBL:ADL40248.1};
RX PubMed=21393132; DOI=10.1093/jac/dkq529;
RA Bailey J.K., Pinyon J.L., Anantham S., Hall R.M.;
RT "Distribution of the blaTEM gene and blaTEM-containing transposons in
RT commensal Escherichia coli.";
RL J. Antimicrob. Chemother. 66:745-751(2011).
RN [12] {ECO:0000313|EMBL:ADL40248.1}
RP NUCLEOTIDE SEQUENCE.
RC PLASMID=R1033 {ECO:0000313|EMBL:ADL40248.1};
RX PubMed=21476866; DOI=10.1089/mdr.2010.0196;
RA Pinyon J.L., Hall R.M.;
RT "Evolution of IncP-1? plasmids by acquisition of antibiotic and mercuric
RT ion resistance transposons.";
RL Microb. Drug Resist. 17:339-343(2011).
RN [13] {ECO:0000313|EMBL:AIB52505.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Pavimgi1 {ECO:0000313|EMBL:AIB52505.1};
RX PubMed=25070102; DOI=10.1128/AAC.02372-14;
RA Perez F., Hujer A.M., Marshall S.H., Ray A.J., Rather P.N., Suwantarat N.,
RA Dumford D.III., O'Shea P., Domitrovic T.N., Salata R.A., Chavda K.D.,
RA Chen L., Kreiswirth B.N., Vila A.J., Haussler S., Jacobs M.R., Bonomo R.A.;
RT "Extensively Drug-Resistant Pseudomonas aeruginosa Isolates Containing
RT blaVIM-2 and Elements of Salmonella Genomic Island 2: a New Genetic
RT Resistance Determinant in Northeast Ohio.";
RL Antimicrob. Agents Chemother. 58:5929-5935(2014).
RN [14] {ECO:0000313|EMBL:BAO48033.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TUM3980 {ECO:0000313|EMBL:BAO48033.1};
RA Mano Y., Ishii Y., Yoshizumi Y., Saga T., Furuya N., Yamaguchi K.,
RA Tateda K.;
RT "Diversity of metallo-beta-lactamase genes and integron structures among
RT clinical isolates of Pseudomonas aeruginosa in Japan.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + spectinomycin = 9-O-adenylylspectinomycin + diphosphate;
CC Xref=Rhea:RHEA:63228, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:146260, ChEBI:CHEBI:146261;
CC Evidence={ECO:0000256|ARBA:ARBA00001672,
CC ECO:0000256|PIRNR:PIRNR000819};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + streptomycin = 3''-O-adenylylstreptomycin + diphosphate;
CC Xref=Rhea:RHEA:20245, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:58007, ChEBI:CHEBI:58605; EC=2.7.7.47;
CC Evidence={ECO:0000256|ARBA:ARBA00035070,
CC ECO:0000256|PIRNR:PIRNR000819};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U12338; AAB60002.1; -; Genomic_DNA.
DR EMBL; DQ091178; AAZ07711.1; -; Genomic_DNA.
DR EMBL; EU165040; ABY48979.1; -; Genomic_DNA.
DR EMBL; HM804085; ADL40248.1; -; Genomic_DNA.
DR EMBL; KJ463833; AIB52505.1; -; Genomic_DNA.
DR EMBL; AB901044; BAO48033.1; -; Genomic_DNA.
DR EMBL; AJ634050; CAG23930.1; -; Genomic_DNA.
DR AlphaFoldDB; Q79D85; -.
DR SMR; Q79D85; -.
DR PATRIC; fig|287.2578.peg.308; -.
DR GO; GO:0070566; F:adenylyltransferase activity; IEA:InterPro.
DR GO; GO:0009012; F:aminoglycoside 3''-adenylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR CDD; cd05403; NT_KNTase_like; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR InterPro; IPR024172; AadA/Aad9.
DR InterPro; IPR025184; AadA_C.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002934; Polymerase_NTP_transf_dom.
DR Pfam; PF13427; AadA_C; 1.
DR Pfam; PF01909; NTP_transf_2; 1.
DR PIRSF; PIRSF000819; Streptomycin_3-adenylyltransf; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251,
KW ECO:0000256|PIRNR:PIRNR000819};
KW ATP-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000819};
KW Nucleotidyltransferase {ECO:0000256|PIRNR:PIRNR000819,
KW ECO:0000313|EMBL:AAB60002.1}; Plasmid {ECO:0000313|EMBL:AAB60002.1};
KW Transferase {ECO:0000256|PIRNR:PIRNR000819, ECO:0000313|EMBL:AAB60002.1}.
FT DOMAIN 24..93
FT /note="Polymerase nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF01909"
FT DOMAIN 149..250
FT /note="Adenylyltransferase AadA C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13427"
SQ SEQUENCE 259 AA; 29123 MW; 259A643BC501E75D CRC64;
MTIEISNQLS EVLSVIERHL ESTLLAVHLY GSAVDGGLKP YSDIDLLVTV AVKLDETTRR
ALLNDLMEAS AFPGESETLR AIEVTLVVHD DIIPWRYPAK RELQFGEWQR NDILAGIFEP
AMIDIDLAIL LTKAREHSVA LVGPAAEEFF DPVPEQDLFE ALRETLKLWN SQPDWAGDER
NVVLTLSRIW YSAITGKIAP KDVAADWAIK RLPAQYQPVL LEAKQAYLGQ KEDHLASRAD
HLEEFIRFVK GEIIKSVGK
//